{"id":"https://openalex.org/W1972796947","doi":"https://doi.org/10.3109/08830188809051206","title":"MHC Recombinant Mice: Genetic Tools for Study of Resistance to Viral Disease","display_name":"MHC Recombinant Mice: Genetic Tools for Study of Resistance to Viral Disease","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1972796947","doi":"https://doi.org/10.3109/08830188809051206","mag":"1972796947","pmid":"https://pubmed.ncbi.nlm.nih.gov/3073186"},"language":"en","primary_location":{"id":"doi:10.3109/08830188809051206","doi":"https://doi.org/10.3109/08830188809051206","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08830188809051206","pdf_url":null,"source":{"id":"https://openalex.org/S19733918","display_name":"International Reviews of Immunology","issn_l":"0883-0185","issn":["0883-0185","1026-8006","1563-5244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Reviews of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032220933","display_name":"Bruce W. Chesebro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce Chesebro","raw_affiliation_strings":["Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, Hamilton, Montana 59840","Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, 59840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I4405287673"]},{"raw_affiliation_string":"Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, 59840, USA","institution_ids":["https://openalex.org/I4405287673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032220933"],"corresponding_institution_ids":["https://openalex.org/I4405287673"],"apc_list":null,"apc_paid":null,"fwci":0.0967,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.4512035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":"393","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07360000163316727,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.9810000061988831},{"id":"https://openalex.org/keywords/congenic-mice","display_name":"congenic mice","score":0.8320000171661377},{"id":"https://openalex.org/keywords/viral-disease-resistance","display_name":"viral infection resistance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/retrovirus-infection","display_name":"retroviral infection","score":0.7450000047683716},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.7599999904632568},{"id":"https://openalex.org/keywords/immune-response-genes","display_name":"immune response genes","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.8886227011680603},{"id":"https://openalex.org/C84951073","wikidata":"https://www.wikidata.org/wiki/Q2379153","display_name":"Congenic","level":3,"score":0.7502396106719971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7390165328979492},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6013009548187256},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.507757306098938},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48973584175109863},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4725959897041321},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47148534655570984},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4229598641395569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10319274663925171},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005622","descriptor_name":"Friend murine leukemia virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08830188809051206","doi":"https://doi.org/10.3109/08830188809051206","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08830188809051206","pdf_url":null,"source":{"id":"https://openalex.org/S19733918","display_name":"International Reviews of Immunology","issn_l":"0883-0185","issn":["0883-0185","1026-8006","1563-5244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Reviews of Immunology","raw_type":"journal-article"},{"id":"pmid:3073186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3073186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International reviews of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W40843633","https://openalex.org/W1589480977","https://openalex.org/W1913266639","https://openalex.org/W2015821234","https://openalex.org/W2018175742","https://openalex.org/W2105549288","https://openalex.org/W2116507752","https://openalex.org/W2120931274","https://openalex.org/W2126873525"],"related_works":["https://openalex.org/W244726528","https://openalex.org/W109744084","https://openalex.org/W4407216478","https://openalex.org/W2365155095","https://openalex.org/W165928532","https://openalex.org/W2363591459","https://openalex.org/W56897424","https://openalex.org/W1976723113","https://openalex.org/W2371823050","https://openalex.org/W2397871909"],"abstract_inverted_index":{"Immunology":[0],"has":[1],"existed":[2],"as":[3],"a":[4,24,134],"recognized":[5],"scientific":[6],"field":[7],"for":[8],"more":[9],"than":[10],"50":[11],"years.":[12],"Initially,":[13],"the":[14,37,40,54,62,68,76,88,101,117,148],"immune":[15,34,69],"response":[16,35],"was":[17,94,144],"thought":[18],"of":[19,23,39,53,56,65,67,87,90,116,136,150],"mainly":[20],"in":[21,29,60,84,95,147,154],"terms":[22],"reaction":[25],"to":[26,100,103,127,156],"infectious":[27],"disease":[28],"live":[30],"animals.":[31],"In":[32],"many":[33],"models":[36],"genes":[38,152],"major":[41],"histocompatibility":[42],"complex":[43,63],"(MHC)":[44],"have":[45],"played":[46],"an":[47],"important":[48],"role,":[49],"no":[50],"doubt":[51],"because":[52],"importance":[55],"MHC":[57,129,138,151],"gene":[58,92],"products":[59,93],"regulating":[61],"interactions":[64],"cells":[66],"system.":[70],"It":[71],"is":[72],"now":[73],"obvious":[74],"that":[75],"rapid":[77],"progress":[78],"made":[79],"nearly":[80],"20":[81],"years":[82],"ago":[83],"understanding":[85],"some":[86],"functions":[89],"these":[91,120],"very":[96],"large":[97],"measure":[98],"do":[99],"ability":[102],"study":[104],"and":[105],"compare":[106],"inbred":[107],"mouse":[108],"populations":[109],"differing":[110],"genetically":[111],"only":[112],"at":[113],"certain":[114],"regions":[115],"MHC.":[118],"Often":[119],"early":[121],"functional":[122],"observations":[123],"could":[124],"be":[125],"assigned":[126],"particular":[128],"subregions":[130],"merely":[131],"by":[132],"testing":[133],"panel":[135],"congenic":[137],"recombinant":[139],"mice":[140],"[1,":[141],"2].":[142],"This":[143],"particularly":[145],"true":[146],"case":[149],"involved":[153],"resistance":[155],"retroviral":[157],"diseases":[158],"[3-5].":[159]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}