{"id":"https://openalex.org/W1972504387","doi":"https://doi.org/10.1371/journal.ppat.1003687","title":"Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites during Primary Infection","display_name":"Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites during Primary Infection","publication_year":2013,"publication_date":"2013-10-03","ids":{"openalex":"https://openalex.org/W1972504387","doi":"https://doi.org/10.1371/journal.ppat.1003687","mag":"1972504387","pmid":"https://pubmed.ncbi.nlm.nih.gov/24098130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3789779"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1003687","doi":"https://doi.org/10.1371/journal.ppat.1003687","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003687","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003687&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003687&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049232760","display_name":"Nicolas Albert Gillet","orcid":"https://orcid.org/0000-0002-9410-8738","observed_orcids":["https://orcid.org/0000-0002-9410-8738"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Nicolas A. Gillet","raw_affiliation_strings":["Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium ; Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium ; Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"]},{"raw_affiliation_string":"Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"]},{"raw_affiliation_string":"Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110750621","display_name":"Ger\u00f3nimo Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ger\u00f3nimo Guti\u00e9rrez","raw_affiliation_strings":["Instituto de Virolog\u00eda, Centro de Investigaciones en Ciencias Veterinarias y Agron\u00f3micas, INTA, Castelar, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Virolog\u00eda, Centro de Investigaciones en Ciencias Veterinarias y Agron\u00f3micas, INTA, Castelar, Argentina","institution_ids":["https://openalex.org/I4210153948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069733853","display_name":"Sabrina Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-1159-484X","observed_orcids":["https://orcid.org/0000-0002-1159-484X"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sabrina M. Rodriguez","raw_affiliation_strings":["Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"]},{"raw_affiliation_string":"Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063124527","display_name":"Alix de Brogniez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alix de Brogniez","raw_affiliation_strings":["Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"]},{"raw_affiliation_string":"Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057629892","display_name":"Nathalie Renotte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nathalie Renotte","raw_affiliation_strings":["Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"]},{"raw_affiliation_string":"Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028139336","display_name":"Irene \u00c1lvarez","orcid":"https://orcid.org/0000-0001-5194-670X","observed_orcids":["https://orcid.org/0000-0001-5194-670X"]},"institutions":[{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Irene Alvarez","raw_affiliation_strings":["Instituto de Virolog\u00eda, Centro de Investigaciones en Ciencias Veterinarias y Agron\u00f3micas, INTA, Castelar, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Virolog\u00eda, Centro de Investigaciones en Ciencias Veterinarias y Agron\u00f3micas, INTA, Castelar, Argentina","institution_ids":["https://openalex.org/I4210153948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062946490","display_name":"Karina Gabriela Trono","orcid":"https://orcid.org/0000-0002-1048-4729","observed_orcids":["https://orcid.org/0000-0002-1048-4729"]},"institutions":[{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Karina Trono","raw_affiliation_strings":["Instituto de Virolog\u00eda, Centro de Investigaciones en Ciencias Veterinarias y Agron\u00f3micas, INTA, Castelar, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Virolog\u00eda, Centro de Investigaciones en Ciencias Veterinarias y Agron\u00f3micas, INTA, Castelar, Argentina","institution_ids":["https://openalex.org/I4210153948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052552737","display_name":"Luc Willems","orcid":"https://orcid.org/0000-0002-0563-2213","observed_orcids":["https://orcid.org/0000-0002-0563-2213"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Luc Willems","raw_affiliation_strings":["Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Li\u00e8ge (ULg), Gembloux, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"]},{"raw_affiliation_string":"Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Li\u00e8ge (ULg), Sart-Tilman, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049232760","https://openalex.org/A5052552737"],"corresponding_institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":4.0233,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.94304591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"9","issue":"10","first_page":"e1003687","last_page":"e1003687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-leukemia-virus","display_name":"bovine leukemia virus","score":1.0},{"id":"https://openalex.org/keywords/proviral-integration","display_name":"proviral integration","score":0.6729999780654907},{"id":"https://openalex.org/keywords/primary-infection","display_name":"primary infection","score":0.5799999833106995},{"id":"https://openalex.org/keywords/negative-selection","display_name":"negative selection","score":0.5519999861717224},{"id":"https://openalex.org/keywords/transcribed-regions","display_name":"transcribed regions","score":0.625},{"id":"https://openalex.org/keywords/proviral-load","display_name":"proviral load","score":0.5400000214576721},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.8579999804496765},{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.7110000252723694},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.9606983661651611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.867351770401001},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.791265606880188},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6326290965080261},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5265039801597595},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4951256811618805},{"id":"https://openalex.org/C2778645089","wikidata":"https://www.wikidata.org/wiki/Q895365","display_name":"Bovine leukemia virus","level":3,"score":0.4647933840751648},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43440529704093933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4135668873786926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3708072900772095},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3448445498943329},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001909","descriptor_name":"Leukemia Virus, Bovine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001909","descriptor_name":"Leukemia Virus, Bovine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016583","descriptor_name":"Enzootic Bovine Leukosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016583","descriptor_name":"Enzootic Bovine Leukosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":13,"locations":[{"id":"doi:10.1371/journal.ppat.1003687","doi":"https://doi.org/10.1371/journal.ppat.1003687","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003687","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003687&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2783278","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3789779","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24098130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24098130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3886146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/23871","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:pubmedcentral.nih.gov:3789779","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3789779/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.786.2698","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.786.2698","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9b/4f/ppat.1003687.PMC3789779.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:850f8676419a491397f915cd99a3a32c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/850f8676419a491397f915cd99a3a32c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 9, Iss 10, p e1003687 (2013)","raw_type":"article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/152317","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/152317","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"16th International Conference on Human Retrovirology HTLV and Related Viruses, Montreal, Canada [CA], 26-06-2013 to 30-06-2013","raw_type":"info:eu-repo/semantics/conferencePaper"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/156900","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/156900","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 9 (10) (2013)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/175056","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/175056","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research annual meeting 2014, San Diego, United States [US], 05-04-2014 to 09-04-2014","raw_type":"info:eu-repo/semantics/conferencePoster"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/23871","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/23871","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"doi:10.60692/cgy8x-d3v74","doi":"https://doi.org/10.60692/cgy8x-d3v74","is_oa":true,"landing_page_url":"https://doi.org/10.60692/cgy8x-d3v74","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/xm51d-hqg17","doi":"https://doi.org/10.60692/xm51d-hqg17","is_oa":true,"landing_page_url":"https://doi.org/10.60692/xm51d-hqg17","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1003687","doi":"https://doi.org/10.1371/journal.ppat.1003687","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003687","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003687&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G263710751","display_name":null,"funder_award_id":"2005-018704","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7404019914","display_name":null,"funder_award_id":"LSHC-CT-2005-018704","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320316367","display_name":"Gouvernement Wallon","ror":"https://ror.org/00jv65847"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320321454","display_name":"Belgian Federal Science Policy Office","ror":"https://ror.org/01fapfv42"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320328144","display_name":"Fondation contre le Cancer","ror":null},{"id":"https://openalex.org/F4320336118","display_name":"Alliance for Accelerating Excellence in Science in Africa","ror":"https://ror.org/05wn4z044"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1972504387.pdf","grobid_xml":"https://content.openalex.org/works/W1972504387.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1519626833","https://openalex.org/W1531198730","https://openalex.org/W1637867377","https://openalex.org/W1828839685","https://openalex.org/W1930491887","https://openalex.org/W1966948503","https://openalex.org/W1972710942","https://openalex.org/W1977325814","https://openalex.org/W1977955400","https://openalex.org/W1979893768","https://openalex.org/W1980869599","https://openalex.org/W1983465033","https://openalex.org/W1984680322","https://openalex.org/W1984903732","https://openalex.org/W1985326180","https://openalex.org/W1996328190","https://openalex.org/W1997923723","https://openalex.org/W1998789189","https://openalex.org/W2006461939","https://openalex.org/W2012620089","https://openalex.org/W2017324476","https://openalex.org/W2021166811","https://openalex.org/W2023730860","https://openalex.org/W2026422480","https://openalex.org/W2026814484","https://openalex.org/W2039725926","https://openalex.org/W2043248836","https://openalex.org/W2046156611","https://openalex.org/W2051936933","https://openalex.org/W2055760934","https://openalex.org/W2056457350","https://openalex.org/W2059488505","https://openalex.org/W2060262242","https://openalex.org/W2070601460","https://openalex.org/W2071794490","https://openalex.org/W2078793877","https://openalex.org/W2082485360","https://openalex.org/W2085746138","https://openalex.org/W2088002901","https://openalex.org/W2090462024","https://openalex.org/W2091175727","https://openalex.org/W2098762621","https://openalex.org/W2100610831","https://openalex.org/W2110018477","https://openalex.org/W2116076032","https://openalex.org/W2120121569","https://openalex.org/W2120594463","https://openalex.org/W2123534830","https://openalex.org/W2126328408","https://openalex.org/W2134731069","https://openalex.org/W2136482257","https://openalex.org/W2137328701","https://openalex.org/W2143094651","https://openalex.org/W2145594887","https://openalex.org/W2152744408","https://openalex.org/W2153984726","https://openalex.org/W2156784269","https://openalex.org/W2159213603","https://openalex.org/W2162193490","https://openalex.org/W2162622294","https://openalex.org/W2163028161","https://openalex.org/W2165109848","https://openalex.org/W2188299120","https://openalex.org/W2266664725","https://openalex.org/W2412478481","https://openalex.org/W2468701495","https://openalex.org/W2765633603"],"related_works":["https://openalex.org/W7095814722","https://openalex.org/W2067643388","https://openalex.org/W2035624311","https://openalex.org/W2623098882","https://openalex.org/W1969950535","https://openalex.org/W7096303882","https://openalex.org/W2043248836","https://openalex.org/W4308432151","https://openalex.org/W1993545159","https://openalex.org/W2020382420"],"abstract_inverted_index":{"Deltaretroviruses":[0],"such":[1],"as":[2,284],"human":[3],"T-lymphotropic":[4],"virus":[5,12],"type":[6],"1":[7],"(HTLV-1)":[8],"and":[9,100,130,155,200,241,257],"bovine":[10],"leukemia":[11,27],"(BLV)":[13],"induce":[14],"a":[15,120,205,210,213,230,291],"persistent":[16],"infection":[17,111,240],"that":[18,162],"remains":[19],"generally":[20],"asymptomatic":[21],"but":[22],"can":[23],"also":[24],"lead":[25],"to":[26,94,128,140,169,209,229,266,277],"or":[28,41,212,255],"lymphoma.":[29],"These":[30],"viruses":[31],"replicate":[32],"by":[33,112],"infecting":[34],"new":[35],"lymphocytes":[36],"(i.e.":[37,149],"the":[38,46,73,82,95,132,136,142,145,150,187,195,217,227,243,278],"infectious":[39],"cycle)":[40],"via":[42],"clonal":[43,170,248,285],"expansion":[44,88],"of":[45,54,66,75,89,97,135,144,152,157,186,194,226,245,271],"infected":[47,67,91],"cells":[48,147,203],"(mitotic":[49],"cycle).":[50],"The":[51,64,269],"relative":[52],"importance":[53],"these":[55],"two":[56],"cycles":[57],"in":[58,119,138,172,293],"viral":[59],"replication":[60,84],"varies":[61],"during":[62,238],"infection.":[63],"majority":[65],"clones":[68,154,196],"are":[69],"created":[70],"early":[71,110],"before":[72],"onset":[74],"an":[76],"efficient":[77],"immune":[78],"response.":[79],"Later":[80],"on,":[81],"main":[83],"route":[85],"is":[86,107],"mitotic":[87],"pre-existing":[90],"clones.":[92],"Due":[93],"paucity":[96],"available":[98,108],"samples":[99],"for":[101],"ethical":[102],"reasons,":[103],"only":[104],"scarce":[105],"data":[106],"on":[109],"HTLV-1.":[113],"Therefore,":[114],"we":[115],"addressed":[116],"this":[117,272],"question":[118],"comparative":[121],"BLV":[122,163,179],"model.":[123],"We":[124,160],"used":[125],"high-throughput":[126],"sequencing":[127],"map":[129],"quantify":[131],"insertion":[133],"sites":[134],"provirus":[137,206,228,292],"order":[139],"monitor":[141],"clonality":[143],"BLV-infected":[146,202],"population":[148],"number":[151],"distinct":[153],"abundance":[156,221,286],"each":[158],"clone).":[159],"found":[161],"propagation":[164],"shifts":[165],"from":[166,176,289],"cell":[167],"neoinfection":[168],"proliferation":[171],"about":[173],"2":[174],"months":[175],"inoculation.":[177],"Initially,":[178],"proviral":[180,279],"integration":[181,252],"significantly":[182],"favors":[183],"transcribed":[184,231,267,294],"regions":[185],"genome.":[188],"Negative":[189],"selection":[190,261],"then":[191],"eliminates":[192],"97%":[193],"detected":[197],"at":[198],"seroconversion":[199],"disfavors":[201],"carrying":[204,290],"located":[207,264],"close":[208],"promoter":[211],"gene.":[214],"Nevertheless,":[215],"among":[216],"surviving":[218],"proviruses,":[219],"clone":[220],"positively":[222],"correlates":[223],"with":[224],"proximity":[225],"region.":[232],"Two":[233],"opposite":[234],"forces":[235],"thus":[236],"operate":[237],"primary":[239],"dictate":[242],"fate":[244],"long":[246],"term":[247],"composition:":[249],"(1)":[250],"initial":[251,273],"inside":[253],"genes":[254],"promoters":[256],"(2)":[258],"host":[259],"negative":[260],"disfavoring":[262],"proviruses":[263],"next":[265],"regions.":[268,295],"result":[270],"response":[274],"will":[275,287],"contribute":[276],"load":[280],"set":[281],"point":[282],"value":[283],"benefit":[288]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
