{"id":"https://openalex.org/W1972476934","doi":"https://doi.org/10.4161/cc.7.5.5701","title":"CARPs enhance p53 turnover by degrading 14-3-3\u03c3 and stabilizing MDM2","display_name":"CARPs enhance p53 turnover by degrading 14-3-3\u03c3 and stabilizing MDM2","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W1972476934","doi":"https://doi.org/10.4161/cc.7.5.5701","mag":"1972476934","pmid":"https://pubmed.ncbi.nlm.nih.gov/18382127"},"language":"en","primary_location":{"id":"doi:10.4161/cc.7.5.5701","doi":"https://doi.org/10.4161/cc.7.5.5701","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.7.5.5701","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.5.5701?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.5.5701?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101861730","display_name":"Wensheng Yang","orcid":"https://orcid.org/0009-0001-8931-908X","observed_orcids":["https://orcid.org/0009-0001-8931-908X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wensheng Yang","raw_affiliation_strings":["Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine (Hematology/Oncology), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine (Hematology/Oncology), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023976873","display_name":"David T. Dicker","orcid":"https://orcid.org/0000-0002-0610-8317","observed_orcids":["https://orcid.org/0000-0002-0610-8317"]},"institutions":[{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Dicker","raw_affiliation_strings":["Laboratory of Molecular Oncology and Cell Cycle Regulation ; Departments of Medicine (Hematology/Oncology) , Pharmacology and Genetics ; The Abramson Comprehensive Cancer Center , and The Institute for Translational Medicine and Therapeutics ; University of Pennsylvania School of Medicine ; Philadelphia , Pennsylvania USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology and Cell Cycle Regulation ; Departments of Medicine (Hematology/Oncology) , Pharmacology and Genetics ; The Abramson Comprehensive Cancer Center , and The Institute for Translational Medicine and Therapeutics ; University of Pennsylvania School of Medicine ; Philadelphia , Pennsylvania USA;","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101498583","display_name":"Jiandong Chen","orcid":"https://orcid.org/0000-0001-6178-8370","observed_orcids":["https://orcid.org/0000-0001-6178-8370","https://orcid.org/0000-0002-2644-3315"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiandong Chen","raw_affiliation_strings":["Molecular Oncology Program ; H. Lee Moffitt Cancer Center and Research Institute ; Tampa , Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Program ; H. Lee Moffitt Cancer Center and Research Institute ; Tampa , Florida USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075201353","display_name":"Wafik S. El\u2010Deiry","orcid":"https://orcid.org/0000-0002-9577-8266","observed_orcids":["https://orcid.org/0000-0002-9577-8266"]},"institutions":[{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wafik S. El-Deiry","raw_affiliation_strings":["Laboratory of Molecular Oncology and Cell Cycle Regulation ; Departments of Medicine (Hematology/Oncology) , Pharmacology and Genetics ; The Abramson Comprehensive Cancer Center , and The Institute for Translational Medicine and Therapeutics ; University of Pennsylvania School of Medicine ; Philadelphia , Pennsylvania USA;","University of Pennsylvania School of Medicine ; 415 Curie Blvd. ; CRB 437A ; Philadelphia , Pennsylvania 19104 USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology and Cell Cycle Regulation ; Departments of Medicine (Hematology/Oncology) , Pharmacology and Genetics ; The Abramson Comprehensive Cancer Center , and The Institute for Translational Medicine and Therapeutics ; University of Pennsylvania School of Medicine ; Philadelphia , Pennsylvania USA;","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania School of Medicine ; 415 Curie Blvd. ; CRB 437A ; Philadelphia , Pennsylvania 19104 USA;","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7391,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.73270076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"5","first_page":"670","last_page":"682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/14-3-3-sigma","display_name":"14-3-3 sigma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mdmx","display_name":"MDMX","score":0.8009999990463257},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.890999972820282},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2777221213","wikidata":"https://www.wikidata.org/wiki/Q10322346","display_name":"MDMX","level":4,"score":0.9300031661987305},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.9018659591674805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8018780946731567},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7041577100753784},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6442071795463562},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5449721217155457},{"id":"https://openalex.org/C2778891732","wikidata":"https://www.wikidata.org/wiki/Q2751223","display_name":"Carp","level":3,"score":0.47336718440055847},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4229901134967804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35574212670326233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2462468147277832},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.21615257859230042},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09906253218650818},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.06581908464431763},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005092","descriptor_name":"Exonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005095","descriptor_name":"Exoribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/cc.7.5.5701","doi":"https://doi.org/10.4161/cc.7.5.5701","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.7.5.5701","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.5.5701?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:18382127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18382127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cc.7.5.5701","doi":"https://doi.org/10.4161/cc.7.5.5701","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.7.5.5701","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.5.5701?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1619152892","display_name":"Mechanisms of Esophageal Carcinogenesis","funder_award_id":"P01CA098101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3007425679","display_name":"Molecular Targets for Drug and Radiation Sensitivity","funder_award_id":"P01CA075138","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4993918357","display_name":"Network for Translational Research: Optical Imaging","funder_award_id":"U54CA105008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5558677347","display_name":"CARP, A Novel Cell Death Regulator","funder_award_id":"R01CA097100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309886","display_name":"Rutgers Cancer Institute of New Jersey","ror":"https://ror.org/05vt9qd57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1972476934.pdf","grobid_xml":"https://content.openalex.org/works/W1972476934.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1965154951","https://openalex.org/W1967955844","https://openalex.org/W1975563698","https://openalex.org/W1976873804","https://openalex.org/W1978406914","https://openalex.org/W1982545718","https://openalex.org/W1983939040","https://openalex.org/W1995926647","https://openalex.org/W2000724093","https://openalex.org/W2004311983","https://openalex.org/W2006313701","https://openalex.org/W2007658328","https://openalex.org/W2008887283","https://openalex.org/W2010045481","https://openalex.org/W2022427127","https://openalex.org/W2023950025","https://openalex.org/W2031078048","https://openalex.org/W2039288045","https://openalex.org/W2040068538","https://openalex.org/W2040876807","https://openalex.org/W2048740077","https://openalex.org/W2049202455","https://openalex.org/W2050745715","https://openalex.org/W2052516738","https://openalex.org/W2059985270","https://openalex.org/W2060972565","https://openalex.org/W2062552623","https://openalex.org/W2065886319","https://openalex.org/W2074545297","https://openalex.org/W2076411120","https://openalex.org/W2080964628","https://openalex.org/W2082979850","https://openalex.org/W2085714333","https://openalex.org/W2093014461","https://openalex.org/W2100747540","https://openalex.org/W2103069797","https://openalex.org/W2105236768","https://openalex.org/W2106718280","https://openalex.org/W2114103020","https://openalex.org/W2114455569","https://openalex.org/W2116914505","https://openalex.org/W2117450502","https://openalex.org/W2120254637","https://openalex.org/W2132888849","https://openalex.org/W2134507382","https://openalex.org/W2135300227","https://openalex.org/W2135994263","https://openalex.org/W2148270074","https://openalex.org/W2158005145","https://openalex.org/W2163894821","https://openalex.org/W2170939558"],"related_works":["https://openalex.org/W2231659009","https://openalex.org/W2116914505","https://openalex.org/W2056530510","https://openalex.org/W2063877452","https://openalex.org/W2313281565","https://openalex.org/W1964845760","https://openalex.org/W2082979850","https://openalex.org/W2068222742","https://openalex.org/W2127084386","https://openalex.org/W2064330613"],"abstract_inverted_index":{"CARP1":[0],"and":[1,28],"CARP2":[2,72,101],"proteins":[3,115],"(CARPs)":[4],"are":[5,70],"E3":[6],"ligases":[7],"that":[8,30,38],"target":[9,76],"p53":[10,24,51,118],"as":[11,13],"well":[12],"phospho-p53":[14],"for":[15,78,93],"degradation.":[16],"Because":[17],"MDM2":[18,41,44,49,63,82,94],"is":[19,89],"a":[20,85],"critical":[21],"regulator":[22],"of":[23,87,100],"turnover,":[25],"we":[26],"investigated":[27],"found":[29,74],"CARPs":[31,39,46],"associate":[32],"with":[33,48,62],"MDM2.":[34],"We":[35],"provide":[36],"evidence":[37],"stabilize":[40],"by":[42,96,112],"inhibiting":[43,54],"self-ubiquitination.":[45],"together":[47],"enhance":[50],"degradation,":[52,79],"thereby":[53],"p53-mediated":[55],"cell":[56],"death.":[57],"CARP":[58,114],"protein":[59],"levels":[60,64],"correlate":[61],"including":[65],"under":[66],"hypoxia":[67],"where":[68],"both":[69],"reduced.":[71],"was":[73],"to":[75,81],"14-3-3sigma":[77],"leading":[80],"stabilization.":[83],"MDMX,":[84],"homolog":[86],"MDM2,":[88],"not":[90],"absolutely":[91],"required":[92],"stabilization":[95],"CARPs,":[97],"although":[98],"overexpression":[99],"enhances":[102],"MDM2/MDMX":[103],"interaction.":[104],"Taken":[105],"together,":[106],"our":[107],"study":[108],"identifies":[109],"novel":[110],"mechanisms":[111],"which":[113],"regulate":[116],"the":[117],"signaling":[119],"pathway.":[120]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}