{"id":"https://openalex.org/W1972389653","doi":"https://doi.org/10.1002/hep.23681","title":"Synergistic role of sprouty2 inactivation and c\u2010Met up\u2010regulation in mouse and human hepatocarcinogenesis\u2020","display_name":"Synergistic role of sprouty2 inactivation and c\u2010Met up\u2010regulation in mouse and human hepatocarcinogenesis\u2020","publication_year":2010,"publication_date":"2010-03-23","ids":{"openalex":"https://openalex.org/W1972389653","doi":"https://doi.org/10.1002/hep.23681","mag":"1972389653","pmid":"https://pubmed.ncbi.nlm.nih.gov/20683950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2920762"},"language":"en","primary_location":{"id":"doi:10.1002/hep.23681","doi":"https://doi.org/10.1002/hep.23681","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.23681","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2920762","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024411111","display_name":"Susie A. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susie A. Lee","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA","Department of Bioengineering and Therapeutic Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056505279","display_name":"Sara Ladu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Ladu","raw_affiliation_strings":["Department of Medicine and Aging, University of Chieti, Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Aging, University of Chieti, Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022582588","display_name":"Matthias Evert","orcid":"https://orcid.org/0009-0001-8412-9682","observed_orcids":["https://orcid.org/0009-0001-8412-9682"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Evert","raw_affiliation_strings":["Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038182004","display_name":"Frank Dombrowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Dombrowski","raw_affiliation_strings":["Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006303022","display_name":"Valentina De Murtas","orcid":"https://orcid.org/0000-0002-6284-3076","observed_orcids":["https://orcid.org/0000-0002-6284-3076"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valentina De Murtas","raw_affiliation_strings":["Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences","Diego F. Calvisi, Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Friedrich-Lo\u0308ffler-Str. 23e, 17489 Greifswald, Germany===","Liver Center, University of California San Francisco (UCSF), San Francisco, CA","Xin Chen, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143===","fax: 415-502-4322","Diego F. Calvisi, Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Friedrich-L\u00f6ffler-Str. 23e, 17489 Greifswald, Germany==="],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences","institution_ids":[]},{"raw_affiliation_string":"Diego F. Calvisi, Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Friedrich-Lo\u0308ffler-Str. 23e, 17489 Greifswald, Germany===","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Liver Center, University of California San Francisco (UCSF), San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Xin Chen, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143===","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"fax: 415-502-4322","institution_ids":[]},{"raw_affiliation_string":"Diego F. Calvisi, Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Friedrich-L\u00f6ffler-Str. 23e, 17489 Greifswald, Germany===","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091038323","display_name":"Diego Francesco Calvisi","orcid":"https://orcid.org/0000-0002-6038-8567","observed_orcids":["https://orcid.org/0000-0002-6038-8567"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Diego F. Calvisi","raw_affiliation_strings":["Diego F. Calvisi, Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Friedrich-Lo\u0308ffler-Str. 23e, 17489 Greifswald, Germany===","Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","Xin Chen, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143===","fax: 0049 3834 865704","Diego F. Calvisi, Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Friedrich-L\u00f6ffler-Str. 23e, 17489 Greifswald, Germany===","Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diego F. Calvisi, Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Friedrich-Lo\u0308ffler-Str. 23e, 17489 Greifswald, Germany===","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Institut fu\u0308r Pathologie, Ernst-Moritz-Arndt-Universita\u0308t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Xin Chen, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143===","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"fax: 0049 3834 865704","institution_ids":[]},{"raw_affiliation_string":"Diego F. Calvisi, Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Friedrich-L\u00f6ffler-Str. 23e, 17489 Greifswald, Germany===","institution_ids":["https://openalex.org/I36522303"]},{"raw_affiliation_string":"Institut f\u00fcr Pathologie, Ernst-Moritz-Arndt-Universit\u00e4t, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091038323","https://openalex.org/A5100363101"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I36522303"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":3.9842,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93426783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"52","issue":"2","first_page":"506","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sprouty2","display_name":"Sprouty2","score":0.925000011920929},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8240000009536743},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9240000247955322},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5581037998199463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4658793807029724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42690154910087585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27866148948669434}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.23681","doi":"https://doi.org/10.1002/hep.23681","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.23681","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:20683950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20683950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2920762","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2920762","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatology","raw_type":"Text"},{"id":"pmh:oai:iris.uniss.it:11388/134302","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11388/134302","pdf_url":null,"source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2920762","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2920762","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hepatology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7336946391","display_name":"A flexible somatic and sporadic mouse model for liver cancers","funder_award_id":"R21CA131625","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8785859341","display_name":"Molecular Genetics of Liver Cancers","funder_award_id":"R01CA136606","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000869253","display_name":"UCSF Liver Center","funder_award_id":"P30DK026743","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1972850991","https://openalex.org/W1978802056","https://openalex.org/W1998832402","https://openalex.org/W2003947764","https://openalex.org/W2012929137","https://openalex.org/W2016891318","https://openalex.org/W2020292268","https://openalex.org/W2022059412","https://openalex.org/W2022625015","https://openalex.org/W2024313468","https://openalex.org/W2042571415","https://openalex.org/W2043649338","https://openalex.org/W2054042846","https://openalex.org/W2054605144","https://openalex.org/W2060525515","https://openalex.org/W2062738482","https://openalex.org/W2067224679","https://openalex.org/W2067526101","https://openalex.org/W2073270386","https://openalex.org/W2074874299","https://openalex.org/W2077219221","https://openalex.org/W2081736906","https://openalex.org/W2082393183","https://openalex.org/W2088004537","https://openalex.org/W2088293068","https://openalex.org/W2089091994","https://openalex.org/W2099789788","https://openalex.org/W2136390065","https://openalex.org/W2137794530","https://openalex.org/W2155737059","https://openalex.org/W2155767204","https://openalex.org/W2160682313","https://openalex.org/W2162242700","https://openalex.org/W2315994925","https://openalex.org/W2409246534","https://openalex.org/W2473185292"],"related_works":["https://openalex.org/W2076999917","https://openalex.org/W2107774730","https://openalex.org/W2949011580","https://openalex.org/W2302797906","https://openalex.org/W2022625015","https://openalex.org/W7100764928","https://openalex.org/W1969276724","https://openalex.org/W1996152129","https://openalex.org/W2529352156","https://openalex.org/W1492284181"],"abstract_inverted_index":{"UNLABELLED:":[0],"Sprouty2":[1],"(Spry2),":[2],"a":[3,79,159,197,222,238],"negative":[4,161],"feedback":[5],"regulator":[6],"of":[7,28,34,52,58,81,112,145,163,185,193,204,231,246],"the":[8,24,35,172,191],"Ras/mitogen-activated":[9],"protein":[10,54],"kinase":[11,68],"(MAPK)":[12],"pathway,":[13],"is":[14,94],"frequently":[15],"down-regulated":[16,123],"in":[17,42,45,78,96,171,226,251],"human":[18,82,97,194,252],"hepatocellular":[19],"carcinoma":[20],"(HCC).":[21],"We":[22,48],"tested":[23],"hypothesis":[25],"that":[26,91,154,218],"loss":[27,111,144],"Spry2":[29,53,92,130,146,156,164,213,219,232],"cooperates":[30,165],"with":[31,85,166,196],"unconstrained":[32],"activation":[33,57,245],"c-Met":[36,59,148,167,234],"protooncogene":[37],"to":[38,168,212],"induce":[39],"hepatocarcinogenesis":[40,170],"via":[41,99,158],"vitro":[43],"and":[44,56,70,105,114,140,178,188,208,233,248],"vivo":[46],"approaches.":[47],"found":[49],"coordinated":[50],"down-regulation":[51],"expression":[55],"as":[60,62,136,138,221],"well":[61,137],"its":[63],"downstream":[64],"effectors":[65],"extracellular":[66],"signal-regulated":[67],"(ERK)":[69],"v-akt":[71],"murine":[72],"thymoma":[73],"viral":[74],"oncogene":[75],"homolog":[76],"(AKT)":[77],"subset":[80],"HCC":[83,98,127,195],"samples":[84],"poor":[86],"outcome.":[87],"Mechanistic":[88],"studies":[89],"revealed":[90],"function":[93],"disrupted":[95],"multiple":[100],"mechanisms":[101],"at":[102],"both":[103],"transcriptional":[104],"post-transcriptional":[106],"level,":[107],"including":[108],"promoter":[109],"hypermethylation,":[110],"heterozygosity,":[113],"proteosomal":[115],"degradation":[116],"by":[117,175],"neural":[118],"precursor":[119],"cell":[120,128,134],"expressed,":[121],"developmentally":[122],"4":[124],"(NEDD4).":[125],"In":[126],"lines,":[129],"overexpression":[131],"inhibits":[132],"c-Met-induced":[133],"proliferation":[135,177],"ERK":[139,187,247],"AKT":[141,249],"activation,":[142],"whereas":[143],"potentiates":[147],"signaling.":[149],"Most":[150],"importantly,":[151],"we":[152],"show":[153],"blocking":[155],"activity":[157],"dominant":[160],"form":[162],"promote":[169],"mouse":[173],"liver":[174,227],"sustaining":[176],"angiogenesis.":[179],"The":[180,202],"tumors":[181],"exhibited":[182],"high":[183],"levels":[184],"activated":[186],"AKT,":[189],"recapitulating":[190],"subgroup":[192],"clinically":[198],"aggressive":[199],"phenotype.":[200],"CONCLUSION:":[201],"occurrence":[203],"frequent":[205],"genetic,":[206],"epigenetic,":[207],"biochemical":[209],"events":[210],"leading":[211],"inactivation":[214],"provides":[215],"solid":[216],"evidence":[217],"functions":[220],"tumor":[223],"suppressor":[224],"gene":[225],"cancer.":[228],"Coordinated":[229],"deregulation":[230],"signaling":[235],"may":[236],"be":[237],"pivotal":[239],"oncogenic":[240],"mechanism":[241],"responsible":[242],"for":[243],"unrestrained":[244],"pathways":[250],"hepatocarcinogenesis.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}