{"id":"https://openalex.org/W1972349129","doi":"https://doi.org/10.1016/s0960-894x(99)00071-2","title":"Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: Discovery of L-786,392","display_name":"Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: Discovery of L-786,392","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W1972349129","doi":"https://doi.org/10.1016/s0960-894x(99)00071-2","mag":"1972349129","pmid":"https://pubmed.ncbi.nlm.nih.gov/10201828"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(99)00071-2","doi":"https://doi.org/10.1016/s0960-894x(99)00071-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(99)00071-2","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036390578","display_name":"Ronald W. Ratcliffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.W. Ratcliffe","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065-0900, USA","Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065-0900, USA","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086657296","display_name":"Robert R. Wilkening","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.R. Wilkening","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066945056","display_name":"Kenneth J. Wildonger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.J. Wildonger","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109689334","display_name":"Sherman T. Waddell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.T. Waddell","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041512274","display_name":"Gina M. Santorelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.M. Santorelli","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077495456","display_name":"Dann L. Parker","orcid":"https://orcid.org/0000-0002-2338-4540","observed_orcids":["https://orcid.org/0000-0002-2338-4540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.L. Parker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081107625","display_name":"Jerry D. Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.D. Morgan","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053040103","display_name":"Timothy A. Blizzard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.A. Blizzard","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071129219","display_name":"Milton L. Hammond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.L. Hammond","raw_affiliation_strings":["Department of Biochemsitry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemsitry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110620591","display_name":"James V. Heck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.V. Heck","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Huber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Huber","raw_affiliation_strings":["Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007833321","display_name":"Joyce Kohler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kohler","raw_affiliation_strings":["Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043851847","display_name":"Karen Dorso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.L. Dorso","raw_affiliation_strings":["Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101579066","display_name":"Earl St. Rose","orcid":"https://orcid.org/0000-0001-7269-437X","observed_orcids":["https://orcid.org/0000-0001-7269-437X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. St. Rose","raw_affiliation_strings":["Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009362855","display_name":"Jon G. Sundelof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.G. Sundelof","raw_affiliation_strings":["Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W.J. May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.J. May","raw_affiliation_strings":["Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001116566","display_name":"Gail G. Hammond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.G. Hammond","raw_affiliation_strings":["Department of Biochemsitry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemsitry, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065-0900, U.S.A","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":4.0931,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.94411187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"5","first_page":"679","last_page":"684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13489","display_name":"Synthesis of \u03b2-Lactam Compounds","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbapenems","display_name":"carbapenems","score":0.8240000009536743},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/anti-mrsa-activity","display_name":"anti-MRSA activity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/beta-lactam-antibiotics","display_name":"beta-lactam antibiotics","score":0.7620000243186951},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.7829999923706055},{"id":"https://openalex.org/keywords/beta-lactam-ring-opening","display_name":"\u03b2-lactam ring opening","score":0.8399999737739563},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8430624008178711},{"id":"https://openalex.org/C2776131168","wikidata":"https://www.wikidata.org/wiki/Q251124","display_name":"Lactam","level":2,"score":0.8006473779678345},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7889896631240845},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.670924186706543},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.6142523288726807},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5820772051811218},{"id":"https://openalex.org/C161369605","wikidata":"https://www.wikidata.org/wiki/Q41803","display_name":"Gram","level":3,"score":0.5139729380607605},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.471658855676651},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.4606388509273529},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4550524652004242},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43821531534194946},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4004139006137848},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3716861605644226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16944801807403564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(99)00071-2","doi":"https://doi.org/10.1016/s0960-894x(99)00071-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(99)00071-2","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:10201828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10201828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W162174982","https://openalex.org/W1965478714","https://openalex.org/W1972637497","https://openalex.org/W1985508970","https://openalex.org/W1989462201","https://openalex.org/W1990615894","https://openalex.org/W1994758557","https://openalex.org/W2003379019","https://openalex.org/W2030340541","https://openalex.org/W2036658163","https://openalex.org/W2042616093","https://openalex.org/W2044104747","https://openalex.org/W2046664220","https://openalex.org/W2061387719","https://openalex.org/W2085927992","https://openalex.org/W2104312420","https://openalex.org/W2130070129","https://openalex.org/W2141640874","https://openalex.org/W2949715498"],"related_works":["https://openalex.org/W2949902655","https://openalex.org/W1965478714","https://openalex.org/W2806934241","https://openalex.org/W2068818421","https://openalex.org/W1985508970","https://openalex.org/W2045988032","https://openalex.org/W2952373720","https://openalex.org/W2178467629","https://openalex.org/W2052957535","https://openalex.org/W2045030010"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
