{"id":"https://openalex.org/W1972306899","doi":"https://doi.org/10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","title":"Antisteroidal compounds and steroid withdrawal down-regulate cadherin-11 mRNA and protein expression levels in human endometrial stromal cells undergoing decidualisation in vitro","display_name":"Antisteroidal compounds and steroid withdrawal down-regulate cadherin-11 mRNA and protein expression levels in human endometrial stromal cells undergoing decidualisation in vitro","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W1972306899","doi":"https://doi.org/10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","mag":"1972306899","pmid":"https://pubmed.ncbi.nlm.nih.gov/10398413"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","doi":"https://doi.org/10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018540676","display_name":"George T.C. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"George T.C. Chen","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060836893","display_name":"Spiro Getsios","orcid":"https://orcid.org/0000-0002-1141-4562","observed_orcids":["https://orcid.org/0000-0002-1141-4562"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Spiro Getsios","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008234591","display_name":"Colin D. MacCalman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Colin D. MacCalman","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008234591"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":0.114,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.42071063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"53","issue":"4","first_page":"384","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.13429999351501465,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadherin-11","display_name":"cadherin-11","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endometrial-stromal-cells","display_name":"endometrial stromal cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/decidualization","display_name":"decidualization","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antiprogestins","display_name":"antiprogestins","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ru486","display_name":"RU486","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.8309999704360962},{"id":"https://openalex.org/keywords/progesterone-withdrawal","display_name":"progesterone withdrawal","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7450000047683716},{"id":"https://openalex.org/keywords/estrogen-regulation","display_name":"estrogen regulation","score":0.40700000524520874},{"id":"https://openalex.org/keywords/endometrial-remodeling","display_name":"endometrial remodeling","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9739401936531067},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7582834362983704},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5353124141693115},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5078371167182922},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47824397683143616},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4680936634540558},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.46101701259613037},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.45572394132614136},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41446900367736816},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3188307285308838},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3036620616912842},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2859746813774109},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18548163771629333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1347540318965912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077267","descriptor_name":"Fulvestrant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004717","descriptor_name":"Endometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006727","descriptor_name":"Hormone Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","doi":"https://doi.org/10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2795(199908)53:4<384::aid-mrd3>3.0.co;2-0","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:10398413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10398413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1451684643","https://openalex.org/W1587777046","https://openalex.org/W1835634388","https://openalex.org/W1934084651","https://openalex.org/W1976690137","https://openalex.org/W1979013819","https://openalex.org/W1980638951","https://openalex.org/W1981752846","https://openalex.org/W1990323563","https://openalex.org/W1993136477","https://openalex.org/W2000846408","https://openalex.org/W2009750404","https://openalex.org/W2012831570","https://openalex.org/W2029421093","https://openalex.org/W2042154738","https://openalex.org/W2054553315","https://openalex.org/W2064494203","https://openalex.org/W2073836271","https://openalex.org/W2084457841","https://openalex.org/W2086479929","https://openalex.org/W2087230412","https://openalex.org/W2088580995","https://openalex.org/W2099908454","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2134812217","https://openalex.org/W2140437708","https://openalex.org/W2142154203","https://openalex.org/W2152020473","https://openalex.org/W2291036311","https://openalex.org/W2292381286","https://openalex.org/W2295027276","https://openalex.org/W2347010436","https://openalex.org/W2395299746","https://openalex.org/W2488707573","https://openalex.org/W4242838352","https://openalex.org/W4294216491"],"related_works":["https://openalex.org/W2087230412","https://openalex.org/W2296034726","https://openalex.org/W1976690137","https://openalex.org/W4244853392","https://openalex.org/W1990323563","https://openalex.org/W1977060444","https://openalex.org/W2335001376","https://openalex.org/W2168758189","https://openalex.org/W2086282830","https://openalex.org/W2063955464"],"abstract_inverted_index":{"The":[0],"cellular":[1],"mechanisms":[2],"by":[3,65,204],"which":[4,205],"steroids":[5],"and":[6,46,85,93,115,126,139],"antisteroidal":[7],"compounds":[8],"modulate":[9],"the":[10,15,25,28,52,57,70,79,82,86,108,111,149,167,202,226,232,240],"function":[11],"and/or":[12],"integrity":[13],"of":[14,27,54,72,81,110,134,169,242],"human":[16,98,157,233],"endometrium":[17,58,234],"remain":[18],"poorly":[19],"understood.":[20],"We":[21],"recently":[22],"determined":[23],"that":[24,148,216,229],"expression":[26,71,95,141,154,172],"novel":[29],"cadherin":[30],"subtype,":[31],"known":[32],"as":[33],"cadherin-11,":[34],"is":[35,164],"tightly":[36],"regulated":[37],"in":[38,44,47,63,97,104,119,123,143,152,156,162,177,187,225,231,235,239],"endometrial":[39,99,158,178],"stromal":[40,100,136,179,208],"cells":[41,101,159],"undergoing":[42,102,160],"decidualisation":[43,103,161],"vivo":[45],"vitro.":[48,105],"To":[49],"determine":[50],"whether":[51],"actions":[53],"antisteroids":[55],"on":[56,90,166],"are":[59],"mediated,":[60],"at":[61],"least":[62],"part,":[64],"their":[66],"ability":[67],"to":[68,183,237],"regulate":[69],"this":[73,217],"cell":[74,121,180,218],"adhesion":[75,219],"molecule,":[76],"we":[77],"examined":[78],"effects":[80],"antiprogestin":[83],"RU486":[84,106],"antiestrogen":[87],"ICI":[88,130],"182,780":[89,131],"cadherin-11":[91,112,137,153,209],"mRNA":[92,113,138],"protein":[94,116,140],"levels":[96,109,142,155,173,241],"decreased":[107],"transcript":[114],"species":[117],"present":[118],"these":[120],"cultures":[122,181],"a":[124,144,222],"dose-":[125],"time-dependent":[127],"manner.":[128],"Similarly,":[129],"was":[132],"capable":[133],"reducing":[135],"dose-dependent":[145],"manner,":[146],"suggesting":[147],"progesterone-mediated":[150],"increase":[151],"vitro":[163,188],"dependent":[165],"presence":[168],"estrogens.":[170],"Cadherin-11":[171],"also":[174],"were":[175],"reduced":[176],"subjected":[182],"progesterone":[184,206],"withdrawal,":[185],"an":[186],"model":[189],"for":[190],"menstrual":[191],"breakdown.":[192],"These":[193],"studies":[194],"not":[195],"only":[196],"give":[197],"us":[198],"useful":[199],"insight":[200],"into":[201],"mechanism(s)":[203],"regulates":[207],"expression,":[210],"but":[211],"they":[212],"strengthen":[213],"our":[214],"hypothesis":[215],"molecule":[220],"plays":[221],"central":[223],"role":[224],"remodeling":[227],"processes":[228],"occur":[230],"response":[236],"fluctuations":[238],"gonadal":[243],"steroids.":[244]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}