{"id":"https://openalex.org/W1972306191","doi":"https://doi.org/10.1074/jbc.m807725200","title":"Enhancer of Polycomb1 Acts on Serum Response Factor to Regulate Skeletal Muscle Differentiation","display_name":"Enhancer of Polycomb1 Acts on Serum Response Factor to Regulate Skeletal Muscle Differentiation","publication_year":2009,"publication_date":"2009-04-10","ids":{"openalex":"https://openalex.org/W1972306191","doi":"https://doi.org/10.1074/jbc.m807725200","mag":"1972306191","pmid":"https://pubmed.ncbi.nlm.nih.gov/19359245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713522"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m807725200","doi":"https://doi.org/10.1074/jbc.m807725200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m807725200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m807725200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089987309","display_name":"Ju\u2010Ryoung Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-Ryoung Kim","raw_affiliation_strings":["Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","Departments of Surgery, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","Departments of Pharmacology, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Departments of Surgery, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068223655","display_name":"Hae Jin Kee","orcid":"https://orcid.org/0000-0002-9774-4828","observed_orcids":["https://orcid.org/0000-0002-9774-4828"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hae Jin Kee","raw_affiliation_strings":["From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","Departments of Pharmacology, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384058","display_name":"Jiyoung Kim","orcid":"https://orcid.org/0000-0002-2999-3320","observed_orcids":["https://orcid.org/0000-0002-2999-3320","https://orcid.org/0009-0002-6993-068X"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Young Kim","raw_affiliation_strings":["Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","Departments of Surgery, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Departments of Surgery, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085913279","display_name":"Hosouk Joung","orcid":"https://orcid.org/0000-0002-1918-0182","observed_orcids":["https://orcid.org/0000-0002-1918-0182"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hosouk Joung","raw_affiliation_strings":["From the Medical Research Center for Gene Regulation, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040340052","display_name":"Kyung Keun Kim","orcid":"https://orcid.org/0000-0002-7346-9526","observed_orcids":["https://orcid.org/0000-0002-7346-9526","https://orcid.org/0000-0001-5380-6815"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang-Il Nam","raw_affiliation_strings":["BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746; Anatomy, Gwangju 501-746","Anatomy, Gwangju 501-746","BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746; Anatomy, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Anatomy, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058600119","display_name":"Gwang Hyeon Eom","orcid":"https://orcid.org/0000-0002-7904-8503","observed_orcids":["https://orcid.org/0000-0002-7904-8503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gwang Hyeon Eom","raw_affiliation_strings":["From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","Departments of Pharmacology, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036234645","display_name":"Nakwon Choe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nakwon Choe","raw_affiliation_strings":["From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","Departments of Pharmacology, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101634503","display_name":"Hyungsuk Kim","orcid":"https://orcid.org/0000-0003-3919-4597","observed_orcids":["https://orcid.org/0000-0003-3919-4597"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Suk Kim","raw_affiliation_strings":["BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746; Forensic Medicine, Gwangju 501-746","BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","Forensic Medicine, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746; Forensic Medicine, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Forensic Medicine, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109144665","display_name":"Jeong Chul Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong Chul Kim","raw_affiliation_strings":["Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","Departments of Surgery, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Departments of Surgery, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013181554","display_name":"Hoon Kook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoon Kook","raw_affiliation_strings":["From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746. Electronic address: kookhyun@chonnam.ac.kr","Pediatrics, Chonnam National University Hospital, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746. Electronic address: kookhyun@chonnam.ac.kr","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Pediatrics, Chonnam National University Hospital, Gwangju 501-746","institution_ids":["https://openalex.org/I4210092150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159585455","display_name":"Sang Beom Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Beom Seo","raw_affiliation_strings":["Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-745, South Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024605952","display_name":"Hyun Kook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210092150","display_name":"Chonnam National University Hospital","ror":"https://ror.org/00f200z37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyun Kook","raw_affiliation_strings":["From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746. Electronic address: kookhyun@chonnam.ac.kr","Pediatrics, Chonnam National University Hospital, Gwangju 501-746","BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","Departments of Pharmacology, Gwangju 501-746","From the Medical Research Center for Gene Regulation, Gwangju 501-746"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746; Departments of Pharmacology, Gwangju 501-746; BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746. Electronic address: kookhyun@chonnam.ac.kr","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Pediatrics, Chonnam National University Hospital, Gwangju 501-746","institution_ids":["https://openalex.org/I4210092150"]},{"raw_affiliation_string":"BK 21 Center for Biomedical Human Resources, Chonnam National University Medical School, Gwangju 501-746","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Departments of Pharmacology, Gwangju 501-746","institution_ids":[]},{"raw_affiliation_string":"From the Medical Research Center for Gene Regulation, Gwangju 501-746","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024605952"],"corresponding_institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4210092150"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1102,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.73279279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"284","issue":"24","first_page":"16308","last_page":"16316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-response-factor","display_name":"serum response factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9829999804496765},{"id":"https://openalex.org/keywords/skeletal-muscle-differentiation","display_name":"skeletal muscle differentiation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.7540000081062317},{"id":"https://openalex.org/keywords/carg-box","display_name":"CArG box","score":0.7300000190734863},{"id":"https://openalex.org/keywords/serum-response-element","display_name":"serum response element","score":0.8379999995231628},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.5299999713897705},{"id":"https://openalex.org/keywords/multinucleation","display_name":"multinucleation","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7974594831466675},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.7887042760848999},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6104243993759155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5976938605308533},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5638309121131897},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5362643003463745},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.471581369638443},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.42992761731147766},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41413599252700806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21982795000076294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20301508903503418},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16139286756515503}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D026362","descriptor_name":"Serum Response Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050881","descriptor_name":"E1A-Associated p300 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m807725200","doi":"https://doi.org/10.1074/jbc.m807725200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m807725200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2713522","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:19359245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19359245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m807725200","doi":"https://doi.org/10.1074/jbc.m807725200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m807725200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W58010252","https://openalex.org/W1595752904","https://openalex.org/W1900657670","https://openalex.org/W1918506973","https://openalex.org/W1967399270","https://openalex.org/W1968931043","https://openalex.org/W1980156049","https://openalex.org/W1984246427","https://openalex.org/W1985607497","https://openalex.org/W1994587676","https://openalex.org/W1994664901","https://openalex.org/W1995150531","https://openalex.org/W1999559385","https://openalex.org/W2006858016","https://openalex.org/W2014736194","https://openalex.org/W2020672093","https://openalex.org/W2020891438","https://openalex.org/W2022188551","https://openalex.org/W2026325417","https://openalex.org/W2028910606","https://openalex.org/W2034759240","https://openalex.org/W2036465717","https://openalex.org/W2058225109","https://openalex.org/W2059088759","https://openalex.org/W2059733673","https://openalex.org/W2064923918","https://openalex.org/W2065982809","https://openalex.org/W2066041822","https://openalex.org/W2070516871","https://openalex.org/W2081099987","https://openalex.org/W2096628719","https://openalex.org/W2105308330","https://openalex.org/W2111578933","https://openalex.org/W2115034716","https://openalex.org/W2119932644","https://openalex.org/W2123001330","https://openalex.org/W2130562212","https://openalex.org/W2131845382","https://openalex.org/W2143925803","https://openalex.org/W2147927258","https://openalex.org/W2166021986","https://openalex.org/W2168234009"],"related_works":["https://openalex.org/W1975421704","https://openalex.org/W1995150531","https://openalex.org/W2295849287","https://openalex.org/W2145183379","https://openalex.org/W1497808493","https://openalex.org/W1974557810","https://openalex.org/W2073905722","https://openalex.org/W1824412389","https://openalex.org/W2027547668","https://openalex.org/W1996584284"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1,26,55,182,193],"differentiation":[2,194],"is":[3,189],"well":[4,77],"regulated":[5],"by":[6,150,156,195],"a":[7,20,100,132],"series":[8],"of":[9,17,31,63,72,94,105,113,128,170,204],"transcription":[10],"factors.":[11],"We":[12],"reported":[13],"previously":[14],"that":[15,42,187],"enhancer":[16],"polycomb1":[18],"(Epc1),":[19],"chromatin":[21],"protein,":[22],"can":[23],"modulate":[24],"skeletal":[25,54,73,85,115,139,171,192],"differentiation,":[27],"although":[28],"the":[29,69,84,91,95,103,114,123,126,138,174,178,202],"mechanisms":[30],"this":[32],"action":[33],"have":[34],"yet":[35],"to":[36,52,65,122,137,161,201],"be":[37],"defined.":[38],"Here":[39],"we":[40],"report":[41],"Epc1":[43,57,64,97,129,142,158,188],"recruits":[44],"both":[45,197],"serum":[46,109],"response":[47,110],"factor":[48],"(SRF)":[49],"and":[50,125,173,199],"p300":[51,153,162,200],"induce":[53],"differentiation.":[56,183],"interacted":[58],"physically":[59],"with":[60,108,152],"SRF.":[61],"Transfection":[62],"myoblast":[66,164],"cells":[67],"potentiated":[68,149],"SRF-induced":[70],"expression":[71],"muscle-specific":[74,205],"genes":[75],"as":[76,78],"multinucleation.":[79],"Proximal":[80],"CArG":[81],"box":[82],"in":[83,102,131,134,163],"alpha-actin":[86,116,140],"promoter":[87],"was":[88,148],"responsible":[89],"for":[90,191],"synergistic":[92],"activation":[93],"promoter-luciferase.":[96],"knockdown":[98,127],"caused":[99],"decrease":[101,133],"acetylation":[104],"histones":[106],"associated":[107],"element":[111],"(SRE)":[112],"promoter.":[117,141],"The":[118],"Epc1.SRF":[119],"complex":[120],"bound":[121,160],"SRE,":[124],"resulted":[130],"SRF":[135,198],"binding":[136],"recruited":[143],"histone":[144],"acetyltransferase":[145],"activity,":[146],"which":[147],"cotransfection":[151],"but":[154],"abolished":[155],"si-p300.":[157],"directly":[159],"cells.":[165],"Epc1+/-":[166],"mice":[167,179],"showed":[168],"distortion":[169],"alpha-actin,":[172],"isolated":[175],"myoblasts":[176],"from":[177],"had":[180],"impaired":[181],"These":[184],"results":[185],"suggest":[186],"required":[190],"recruiting":[196],"SRE":[203],"gene":[206],"promoters.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
