{"id":"https://openalex.org/W1972297528","doi":"https://doi.org/10.1016/j.toxicon.2008.07.015","title":"Two coagulation factor X activators from Vipera a. ammodytes venom with potential to treat patients with dysfunctional factors IXa or VIIa","display_name":"Two coagulation factor X activators from Vipera a. ammodytes venom with potential to treat patients with dysfunctional factors IXa or VIIa","publication_year":2008,"publication_date":"2008-08-13","ids":{"openalex":"https://openalex.org/W1972297528","doi":"https://doi.org/10.1016/j.toxicon.2008.07.015","mag":"1972297528","pmid":"https://pubmed.ncbi.nlm.nih.gov/18760294"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxicon.2008.07.015","doi":"https://doi.org/10.1016/j.toxicon.2008.07.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxicon.2008.07.015","pdf_url":null,"source":{"id":"https://openalex.org/S42803210","display_name":"Toxicon","issn_l":"0041-0101","issn":["0041-0101","1879-3150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051008509","display_name":"Adrijana Leonardi","orcid":"https://orcid.org/0000-0001-9854-9955","observed_orcids":["https://orcid.org/0000-0001-9854-9955"]},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]},{"id":"https://openalex.org/I4210113529","display_name":"Jo\u017eef Stefan International Postgraduate School","ror":"https://ror.org/01hdkb925","country_code":"SI","type":"education","lineage":["https://openalex.org/I4210113529"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Adrijana Leonardi","raw_affiliation_strings":["Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, Jamova Street 39, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, Jozef Stefan Institute, Jamova Street 39, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408","https://openalex.org/I4210113529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041069370","display_name":"Jay W. Fox","orcid":"https://orcid.org/0000-0003-4600-1132","observed_orcids":["https://orcid.org/0000-0003-4600-1132"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay W. Fox","raw_affiliation_strings":["Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055894958","display_name":"Alenka Trampu\u0161-Bakija","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801323708","display_name":"Ljubljana University Medical Centre","ror":"https://ror.org/01nr6fy72","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I2801323708"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Alenka Trampu\u0161-Bakija","raw_affiliation_strings":["Medical Centre Ljubljana, Division of Paediatrics, Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Centre Ljubljana, Division of Paediatrics, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I2801323708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034321058","display_name":"Igor Kri\u017eaj","orcid":"https://orcid.org/0000-0003-0203-0708","observed_orcids":["https://orcid.org/0000-0003-0203-0708"]},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]},{"id":"https://openalex.org/I4210113529","display_name":"Jo\u017eef Stefan International Postgraduate School","ror":"https://ror.org/01hdkb925","country_code":"SI","type":"education","lineage":["https://openalex.org/I4210113529"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Igor Kri\u017eaj","raw_affiliation_strings":["Department of Molecular and Biomedical Sciences, Jo\u017eef Stefan Institute, Jamova Street 39, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Sciences, Jo\u017eef Stefan Institute, Jamova Street 39, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408","https://openalex.org/I4210113529"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034321058"],"corresponding_institution_ids":["https://openalex.org/I3006985408","https://openalex.org/I4210113529"],"apc_list":{"value":3340,"currency":"USD","value_usd":3340},"apc_paid":null,"fwci":1.1406,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.77732755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"52","issue":"5","first_page":"628","last_page":"637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vipera-ammodytes-ammodytes","display_name":"Vipera ammodytes ammodytes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/viper-venom","display_name":"viper venom","score":0.8500000238418579},{"id":"https://openalex.org/keywords/glycoproteins","display_name":"glycoproteins","score":0.734000027179718},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.9649999737739563},{"id":"https://openalex.org/keywords/disintegrin-like-domain","display_name":"disintegrin-like domain","score":0.9039999842643738},{"id":"https://openalex.org/keywords/calcium-dependent-activation","display_name":"calcium-dependent activation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/collagen-induced-platelet-aggregation","display_name":"collagen-induced aggregation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/fibrinogen-hydrolysis","display_name":"fibrinogen hydrolysis","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.6491445302963257},{"id":"https://openalex.org/C2910886357","wikidata":"https://www.wikidata.org/wiki/Q425360","display_name":"Factor IXa","level":5,"score":0.6482565402984619},{"id":"https://openalex.org/C27502469","wikidata":"https://www.wikidata.org/wiki/Q906343","display_name":"Dysfunctional family","level":2,"score":0.6254572868347168},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5941663384437561},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4899386763572693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44307300448417664},{"id":"https://openalex.org/C2777444498","wikidata":"https://www.wikidata.org/wiki/Q423701","display_name":"Factor X","level":4,"score":0.40024334192276},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31430041790008545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24852120876312256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1488783359527588},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08521085977554321},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.07541337609291077},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.04843413829803467}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005170","descriptor_name":"Factor X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015942","descriptor_name":"Factor VIIa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015949","descriptor_name":"Factor IXa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D030162","descriptor_name":"Reptilian Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxicon.2008.07.015","doi":"https://doi.org/10.1016/j.toxicon.2008.07.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxicon.2008.07.015","pdf_url":null,"source":{"id":"https://openalex.org/S42803210","display_name":"Toxicon","issn_l":"0041-0101","issn":["0041-0101","1879-3150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicon","raw_type":"journal-article"},{"id":"pmid:18760294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18760294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicon : official journal of the International Society on Toxinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W25654645","https://openalex.org/W269351737","https://openalex.org/W561874568","https://openalex.org/W1506923475","https://openalex.org/W1574819209","https://openalex.org/W1627718954","https://openalex.org/W1871618339","https://openalex.org/W1964069104","https://openalex.org/W1965696475","https://openalex.org/W1967670793","https://openalex.org/W1971876541","https://openalex.org/W1972970439","https://openalex.org/W1974104033","https://openalex.org/W1974886381","https://openalex.org/W1976866837","https://openalex.org/W1977613157","https://openalex.org/W1978899774","https://openalex.org/W1979930762","https://openalex.org/W1981921009","https://openalex.org/W1985981054","https://openalex.org/W1994671779","https://openalex.org/W2002338475","https://openalex.org/W2004941257","https://openalex.org/W2009942259","https://openalex.org/W2018327701","https://openalex.org/W2018800804","https://openalex.org/W2020921331","https://openalex.org/W2022619070","https://openalex.org/W2029136951","https://openalex.org/W2032422402","https://openalex.org/W2034343739","https://openalex.org/W2035605729","https://openalex.org/W2036192239","https://openalex.org/W2045766819","https://openalex.org/W2049856155","https://openalex.org/W2058019691","https://openalex.org/W2066076216","https://openalex.org/W2066170749","https://openalex.org/W2066518618","https://openalex.org/W2066781842","https://openalex.org/W2073141167","https://openalex.org/W2083191763","https://openalex.org/W2084120212","https://openalex.org/W2084821293","https://openalex.org/W2090117493","https://openalex.org/W2097966029","https://openalex.org/W2100837269","https://openalex.org/W2115556295","https://openalex.org/W2137707051","https://openalex.org/W2147000186","https://openalex.org/W2212959237","https://openalex.org/W4237010208"],"related_works":["https://openalex.org/W2034343739","https://openalex.org/W2381835737","https://openalex.org/W1977371464","https://openalex.org/W2363967943","https://openalex.org/W1967670793","https://openalex.org/W2084120212","https://openalex.org/W2022061860","https://openalex.org/W2249002414","https://openalex.org/W2415643675","https://openalex.org/W114560223"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
