{"id":"https://openalex.org/W1972249283","doi":"https://doi.org/10.1002/elps.201000027","title":"Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides","display_name":"Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides","publication_year":2010,"publication_date":"2010-05-05","ids":{"openalex":"https://openalex.org/W1972249283","doi":"https://doi.org/10.1002/elps.201000027","mag":"1972249283","pmid":"https://pubmed.ncbi.nlm.nih.gov/20446295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3104603"},"language":"en","primary_location":{"id":"doi:10.1002/elps.201000027","doi":"https://doi.org/10.1002/elps.201000027","is_oa":false,"landing_page_url":"https://doi.org/10.1002/elps.201000027","pdf_url":null,"source":{"id":"https://openalex.org/S2849398","display_name":"Electrophoresis","issn_l":"0173-0835","issn":["0173-0835","1522-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ELECTROPHORESIS","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3104603","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087312929","display_name":"Hongqian Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hongqian Yang","raw_affiliation_strings":["Division of Molecular Biometry, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biometry, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015270508","display_name":"Roman A. Zubarev","orcid":"https://orcid.org/0000-0001-9839-2089","observed_orcids":["https://orcid.org/0000-0001-9839-2089"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Roman A. Zubarev","raw_affiliation_strings":["Division of Molecular Biometry, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biometry, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015270508"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":0.6292,"has_fulltext":false,"cited_by_count":174,"citation_normalized_percentile":{"value":0.52066116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"31","issue":"11","first_page":"1764","last_page":"1772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asparagine-deamidation","display_name":"asparagine deamidation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-modification","display_name":"protein modification","score":0.5820000171661377},{"id":"https://openalex.org/keywords/high-throughput-analysis","display_name":"high-throughput analysis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/polypeptides","display_name":"polypeptides","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2780784506","wikidata":"https://www.wikidata.org/wiki/Q4859711","display_name":"Deamidation","level":3,"score":0.99721360206604},{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.8437039256095886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7651569843292236},{"id":"https://openalex.org/C126661725","wikidata":"https://www.wikidata.org/wiki/Q903420","display_name":"Isomerization","level":3,"score":0.7471358776092529},{"id":"https://openalex.org/C2781208047","wikidata":"https://www.wikidata.org/wiki/Q178450","display_name":"Aspartic acid","level":3,"score":0.5390327572822571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5206714868545532},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.49617037177085876},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4577658474445343},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4362814426422119},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3605365753173828},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3018138110637665},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.08531615138053894},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.08516505360603333},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.07202738523483276}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001216","descriptor_name":"Asparagine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001216","descriptor_name":"Asparagine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/elps.201000027","doi":"https://doi.org/10.1002/elps.201000027","is_oa":false,"landing_page_url":"https://doi.org/10.1002/elps.201000027","pdf_url":null,"source":{"id":"https://openalex.org/S2849398","display_name":"Electrophoresis","issn_l":"0173-0835","issn":["0173-0835","1522-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ELECTROPHORESIS","raw_type":"journal-article"},{"id":"pmid:20446295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20446295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Electrophoresis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3104603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3104603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Electrophoresis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3104603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3104603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Electrophoresis","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2406023755","display_name":"Defining the IsoAspartome","funder_award_id":"R01GM078293","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W92914774","https://openalex.org/W1511355458","https://openalex.org/W1534259153","https://openalex.org/W1538365263","https://openalex.org/W1583701863","https://openalex.org/W1944789189","https://openalex.org/W1974997650","https://openalex.org/W1975086142","https://openalex.org/W1978150732","https://openalex.org/W1979626824","https://openalex.org/W1982593510","https://openalex.org/W1985171924","https://openalex.org/W1986883813","https://openalex.org/W1998574123","https://openalex.org/W2000144429","https://openalex.org/W2007535730","https://openalex.org/W2018228357","https://openalex.org/W2029436247","https://openalex.org/W2030660796","https://openalex.org/W2031612875","https://openalex.org/W2032947861","https://openalex.org/W2034432214","https://openalex.org/W2038875321","https://openalex.org/W2040999012","https://openalex.org/W2052640073","https://openalex.org/W2056300299","https://openalex.org/W2056854449","https://openalex.org/W2061016075","https://openalex.org/W2063375713","https://openalex.org/W2064868949","https://openalex.org/W2069600125","https://openalex.org/W2078598194","https://openalex.org/W2081159009","https://openalex.org/W2081643248","https://openalex.org/W2085698632","https://openalex.org/W2087488871","https://openalex.org/W2087713555","https://openalex.org/W2089531740","https://openalex.org/W2094905461","https://openalex.org/W2116191505","https://openalex.org/W2121612064","https://openalex.org/W2131741443","https://openalex.org/W2143598772","https://openalex.org/W2169353837","https://openalex.org/W2443763493","https://openalex.org/W2578242640","https://openalex.org/W2950287226"],"related_works":["https://openalex.org/W2030660796","https://openalex.org/W2011888609","https://openalex.org/W4403680569","https://openalex.org/W1997506240","https://openalex.org/W2035340041","https://openalex.org/W1975086142","https://openalex.org/W69738679","https://openalex.org/W2028049825","https://openalex.org/W2336352554","https://openalex.org/W2080803206"],"abstract_inverted_index":{"One":[0],"of":[1,13,23,34,45,69,94],"the":[2,11,37,50,56,63,84,92],"most":[3],"frequent":[4],"modifications":[5],"in":[6],"proteins":[7],"and":[8,26,60,77,90],"peptides":[9],"is":[10],"deamidation":[12],"asparagine,":[14],"a":[15,21],"spontaneous":[16],"non-enzymatic":[17],"reaction":[18],"leading":[19],"to":[20],"mixture":[22],"L,D-succinimidyl,":[24],"L,D-aspartyl,":[25],"L,D-isoaspartyl":[27],"forms,":[28],"with":[29,55,87],"L-isoaspartyl":[30,52],"dominating.":[31],"Spontaneous":[32],"isomerization":[33,59],"L-Asp":[35],"yields":[36],"same":[38],"products.":[39],"In":[40],"vivo,":[41],"these":[42,88],"unusual":[43],"forms":[44],"aspartate":[46],"are":[47],"repaired":[48],"by":[49],"protein":[51],"O-methyltransferase":[53],"enzyme,":[54],"balance":[57,71],"between":[58],"repair":[61],"affecting":[62],"organism":[64],"physiology.":[65],"Mass":[66],"spectrometric":[67],"analysis":[68],"this":[70],"involves":[72],"isomer":[73],"separation,":[74],"iso-Asp/Asp":[75],"quantification,":[76],"iso-Asp":[78,96],"site":[79],"identification.":[80],"This":[81],"review":[82],"highlights":[83],"issues":[85],"associated":[86],"steps":[89],"discusses":[91],"prospects":[93],"high-throughput":[95],"analysis.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
