{"id":"https://openalex.org/W1972241980","doi":"https://doi.org/10.1056/nejm198203253061202","title":"Heart Failure in Outpatients: A Randomized Trial of Digoxin versus Placebo","display_name":"Heart Failure in Outpatients: A Randomized Trial of Digoxin versus Placebo","publication_year":1982,"publication_date":"1982-03-25","ids":{"openalex":"https://openalex.org/W1972241980","doi":"https://doi.org/10.1056/nejm198203253061202","mag":"1972241980","pmid":"https://pubmed.ncbi.nlm.nih.gov/7038483"},"language":"en","primary_location":{"id":"doi:10.1056/nejm198203253061202","doi":"https://doi.org/10.1056/nejm198203253061202","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198203253061202","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108389998","display_name":"Daniel Chia-Sen Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Chia-Sen Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Arnold Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Arnold Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103654832","display_name":"John B. Bingham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John B. Bingham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008180914","display_name":"Marianne Leahy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marianne Leahy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111731353","display_name":"Robert E. Dinsmore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E. Dinsmore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036894001","display_name":"Allan H. Goroll","orcid":"https://orcid.org/0000-0002-3789-7275","observed_orcids":["https://orcid.org/0000-0002-3789-7275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan H. Goroll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013523660","display_name":"John B. Newell","orcid":"https://orcid.org/0000-0001-7685-6655","observed_orcids":["https://orcid.org/0000-0001-7685-6655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John B. Newell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027706324","display_name":"H. William Straus\u015b","orcid":"https://orcid.org/0000-0002-5958-945X","observed_orcids":["https://orcid.org/0000-0002-5958-945X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. William Strauss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111774641","display_name":"Edgar Haber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edgar Haber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":23.3517,"has_fulltext":false,"cited_by_count":450,"citation_normalized_percentile":{"value":0.99765469,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"306","issue":"12","first_page":"699","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9929999709129333},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/digitalis","display_name":"digitalis","score":0.6629999876022339},{"id":"https://openalex.org/keywords/sinus-rhythm","display_name":"sinus rhythm","score":0.7300000190734863},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.7200000286102295},{"id":"https://openalex.org/keywords/third-heart-sound","display_name":"third heart sound","score":0.9319999814033508},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.765999972820282},{"id":"https://openalex.org/keywords/left-ventricular-dilation","display_name":"left ventricular dilatation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/diuretic-therapy","display_name":"diuretic therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/placebo-controlled-crossover-trial","display_name":"placebo-controlled crossover trial","score":0.45899999141693115},{"id":"https://openalex.org/keywords/right-heart-catheterization","display_name":"right heart catheterization","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.9468007683753967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9442898035049438},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8397072553634644},{"id":"https://openalex.org/C2776445394","wikidata":"https://www.wikidata.org/wiki/Q156533","display_name":"Digitalis","level":3,"score":0.7467581033706665},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.707302451133728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6945831179618835},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.693642795085907},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.615714430809021},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.582344651222229},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.5408286452293396},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.44434720277786255},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.322388231754303},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm198203253061202","doi":"https://doi.org/10.1056/nejm198203253061202","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198203253061202","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:7038483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7038483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1501915616","https://openalex.org/W1559468141","https://openalex.org/W1575257760","https://openalex.org/W1974596211","https://openalex.org/W1983091164","https://openalex.org/W1983406707","https://openalex.org/W1988499154","https://openalex.org/W1989090136","https://openalex.org/W1995106690","https://openalex.org/W2004415881","https://openalex.org/W2008615444","https://openalex.org/W2008793466","https://openalex.org/W2009075679","https://openalex.org/W2012250824","https://openalex.org/W2012302103","https://openalex.org/W2013225293","https://openalex.org/W2023478265","https://openalex.org/W2027593377","https://openalex.org/W2028734882","https://openalex.org/W2045341488","https://openalex.org/W2045945043","https://openalex.org/W2085944972","https://openalex.org/W2088349289","https://openalex.org/W2091010105","https://openalex.org/W2091097603","https://openalex.org/W2091104772","https://openalex.org/W2117594247","https://openalex.org/W2138819410","https://openalex.org/W2146421101","https://openalex.org/W2312342505","https://openalex.org/W2738650181","https://openalex.org/W4237521703"],"related_works":["https://openalex.org/W2073162227","https://openalex.org/W2254301302","https://openalex.org/W1495679617","https://openalex.org/W1980974874","https://openalex.org/W2394832256","https://openalex.org/W4411832948","https://openalex.org/W4250615297","https://openalex.org/W7171546507","https://openalex.org/W2007803440","https://openalex.org/W2009847767"],"abstract_inverted_index":{"The":[0,80],"view":[1],"that":[2,118,139],"digitalis":[3],"clinically":[4,144],"benefits":[5],"patients":[6,83,147],"with":[7,148],"heart":[8,53,101,113,121,149,166],"failure":[9,54,150,156],"and":[10,32,98,107,110,161],"sinus":[11],"rhythm":[12],"lacks":[13],"support":[14],"from":[15,88],"a":[16,20,46,111,164],"well-controlled":[17],"study.":[18],"Using":[19],"randomized,":[21],"double-blind,":[22],"crossover":[23],"protocol,":[24],"we":[25],"compared":[26],"the":[27,35,50,119,124,128],"effects":[28],"of":[29,38,52,64,127],"oral":[30],"digoxin":[31,58,94,131,141],"placebo":[33],"on":[34],"clinical":[36],"courses":[37],"25":[39],"outpatients":[40],"without":[41],"atrial":[42,153],"fibrillation.":[43],"According":[44],"to":[45,93,130],"clinicoradiographic":[47],"scoring":[48],"system,":[49],"severity":[51],"was":[55,68,123],"reduced":[56],"by":[57,70,152],"in":[59,62,146],"14":[60],"patients;":[61],"nine":[63],"these":[65],"14,":[66],"improvement":[67,87],"confirmed":[69],"repeated":[71],"trials":[72],"(five":[73],"patients)":[74],"or":[75],"right-heart":[76],"catheterization":[77],"(four":[78],"patients).":[79],"other":[81],"11":[82],"had":[84,95],"no":[85],"detectable":[86],"digoxin.":[89],"Patients":[90],"who":[91,162],"responded":[92],"more":[96,99],"chronic":[97],"severe":[100],"failure,":[102],"greater":[103],"left":[104],"ventricular":[105],"dilation":[106],"ejection-fraction":[108],"depression,":[109],"third":[112,120,165],"sound.":[114,167],"Multivariate":[115],"analysis":[116],"showed":[117],"sound":[122],"strongest":[125],"correlate":[126],"response":[129],"(P":[132],"less":[133],"than":[134],"0.0001).":[135],"These":[136],"data":[137],"suggest":[138],"long-term":[140],"therapy":[142],"is":[143],"beneficial":[145],"unaccompanied":[151],"fibrillation":[154],"whose":[155],"persists":[157],"despite":[158],"diuretic":[159],"treatment":[160],"have":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
