{"id":"https://openalex.org/W1972201352","doi":"https://doi.org/10.1016/s0040-4039(01)80666-3","title":"Regioselective deprotection of 3\u2032,5\u2032-O-acylated pyrimidine nucleosides by lipase and esterase","display_name":"Regioselective deprotection of 3\u2032,5\u2032-O-acylated pyrimidine nucleosides by lipase and esterase","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W1972201352","doi":"https://doi.org/10.1016/s0040-4039(01)80666-3","mag":"1972201352"},"language":"en","primary_location":{"id":"doi:10.1016/s0040-4039(01)80666-3","doi":"https://doi.org/10.1016/s0040-4039(01)80666-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0040-4039(01)80666-3","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111538922","display_name":"Atsuhiko Uemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuhiko Uemura","raw_affiliation_strings":["Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103637792","display_name":"Kenji Nozaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Nozaki","raw_affiliation_strings":["Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780345","display_name":"Jun\u2010ichi Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Yamashita","raw_affiliation_strings":["Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057426385","display_name":"M. YASUMOTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsugi Yasumoto","raw_affiliation_strings":["Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Co., Ltd., Kodama-gun, Saitama, 367-02 JAPAN","institution_ids":["https://openalex.org/I4210120269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210120269"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":1.3999,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.81343507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"30","issue":"29","first_page":"3819","last_page":"3820"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.1818999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regioselective-deprotection","display_name":"regioselective deprotection","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pyrimidine-nucleosides","display_name":"pyrimidine nucleosides","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lipase-catalysis","display_name":"lipase catalysis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/primary-hydroxyl-groups","display_name":"primary hydroxyl groups","score":0.718999981880188},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9764926433563232},{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.9052931070327759},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.8114931583404541},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.7774063348770142},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.6329464316368103},{"id":"https://openalex.org/C2779542420","wikidata":"https://www.wikidata.org/wiki/Q15632647","display_name":"Candida antarctica","level":4,"score":0.5023691654205322},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.49061456322669983},{"id":"https://openalex.org/C193557335","wikidata":"https://www.wikidata.org/wiki/Q61424","display_name":"Acylation","level":3,"score":0.4373827278614044},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3307390511035919},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3183792233467102},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1547173261642456}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0040-4039(01)80666-3","doi":"https://doi.org/10.1016/s0040-4039(01)80666-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0040-4039(01)80666-3","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2026284699","https://openalex.org/W2026829023","https://openalex.org/W2057536928","https://openalex.org/W2081461710"],"related_works":["https://openalex.org/W2950807651","https://openalex.org/W2129054652","https://openalex.org/W2063067048","https://openalex.org/W2052466890","https://openalex.org/W2034535175","https://openalex.org/W2418514373","https://openalex.org/W2005534863","https://openalex.org/W2949402804","https://openalex.org/W2412654452","https://openalex.org/W1977795829"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}