{"id":"https://openalex.org/W1972192602","doi":"https://doi.org/10.1016/j.tiv.2009.05.023","title":"Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba","display_name":"Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba","publication_year":2009,"publication_date":"2009-06-10","ids":{"openalex":"https://openalex.org/W1972192602","doi":"https://doi.org/10.1016/j.tiv.2009.05.023","mag":"1972192602","pmid":"https://pubmed.ncbi.nlm.nih.gov/19501152"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2009.05.023","doi":"https://doi.org/10.1016/j.tiv.2009.05.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2009.05.023","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054282411","display_name":"D. Jyothi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"D. Jyothi","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India","institution_ids":["https://openalex.org/I185638415"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Vanathi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Vanathi","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India","institution_ids":["https://openalex.org/I185638415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059473629","display_name":"P. Mangala Gowri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Mangala Gowri","raw_affiliation_strings":["Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113060776","display_name":"V. Rama Subba Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. Rama Subba Rao","raw_affiliation_strings":["Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110244980","display_name":"Janaswami Madhusudana Rao","orcid":"https://orcid.org/0009-0007-4681-7162","observed_orcids":["https://orcid.org/0009-0007-4681-7162"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. Madhusudana Rao","raw_affiliation_strings":["Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111492176","display_name":"Amere Subbarao Sreedhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"A.S. Sreedhar","raw_affiliation_strings":["Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India","institution_ids":["https://openalex.org/I185638415"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111492176"],"corresponding_institution_ids":["https://openalex.org/I185638415"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.3826,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.8606228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"6","first_page":"1085","last_page":"1091"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piplartine","display_name":"piplartine","score":0.996999979019165},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/piper-chaba","display_name":"Piper chaba","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":1.0},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.7310000061988831},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/embryonal-carcinoma-cells","display_name":"embryonal carcinoma cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6439999938011169},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8182880878448486},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6354464888572693},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5089747905731201},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5061048865318298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4876004755496979},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44894787669181824},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44123750925064087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41912081837654114},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.35958045721054077},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21560516953468323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19664129614830017}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010881","descriptor_name":"Piperidones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010881","descriptor_name":"Piperidones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010881","descriptor_name":"Piperidones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D031701","descriptor_name":"Piper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tiv.2009.05.023","doi":"https://doi.org/10.1016/j.tiv.2009.05.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2009.05.023","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:19501152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19501152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W296450459","https://openalex.org/W592282998","https://openalex.org/W1897747446","https://openalex.org/W1945533339","https://openalex.org/W1965038486","https://openalex.org/W1972477682","https://openalex.org/W1981557521","https://openalex.org/W1991054314","https://openalex.org/W1998727542","https://openalex.org/W2001333050","https://openalex.org/W2005028774","https://openalex.org/W2016992975","https://openalex.org/W2019237247","https://openalex.org/W2027439930","https://openalex.org/W2031451784","https://openalex.org/W2034269086","https://openalex.org/W2037349258","https://openalex.org/W2050850862","https://openalex.org/W2056468898","https://openalex.org/W2057983936","https://openalex.org/W2059555188","https://openalex.org/W2065032246","https://openalex.org/W2066127673","https://openalex.org/W2066234390","https://openalex.org/W2076628443","https://openalex.org/W2081673273","https://openalex.org/W2082762965","https://openalex.org/W2100837269","https://openalex.org/W2101705215","https://openalex.org/W2108987359","https://openalex.org/W2113284006","https://openalex.org/W2116692314","https://openalex.org/W2128635872","https://openalex.org/W2141474275","https://openalex.org/W2153478782","https://openalex.org/W2161299239","https://openalex.org/W4236438320"],"related_works":["https://openalex.org/W2035596633","https://openalex.org/W2343924000","https://openalex.org/W2043930391","https://openalex.org/W2896573423","https://openalex.org/W7120709867","https://openalex.org/W1680469768","https://openalex.org/W3121296671","https://openalex.org/W4386423198","https://openalex.org/W3128248449","https://openalex.org/W2942479626"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
