{"id":"https://openalex.org/W1972154284","doi":"https://doi.org/10.1016/j.neuro.2006.03.012","title":"Protective effect of 17-\u03b2-estradiol in human neurocellular models of lead exposure","display_name":"Protective effect of 17-\u03b2-estradiol in human neurocellular models of lead exposure","publication_year":2006,"publication_date":"2006-04-28","ids":{"openalex":"https://openalex.org/W1972154284","doi":"https://doi.org/10.1016/j.neuro.2006.03.012","mag":"1972154284","pmid":"https://pubmed.ncbi.nlm.nih.gov/16678263"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuro.2006.03.012","doi":"https://doi.org/10.1016/j.neuro.2006.03.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuro.2006.03.012","pdf_url":null,"source":{"id":"https://openalex.org/S115834843","display_name":"NeuroToxicology","issn_l":"0161-813X","issn":["0161-813X","1872-9711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroToxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110179793","display_name":"Chellu S. Chetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159289790","display_name":"Savannah State University","ror":"https://ror.org/00mns7k70","country_code":"US","type":"education","lineage":["https://openalex.org/I159289790"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chellu S. Chetty","raw_affiliation_strings":["Savannah State University, Savannah, GA 31404, USA. chettyc@savstate.edu","Savannah State University, Savannah, GA 31404, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Savannah State University, Savannah, GA 31404, USA. chettyc@savstate.edu","institution_ids":["https://openalex.org/I159289790"]},{"raw_affiliation_string":"Savannah State University, Savannah, GA 31404, USA","institution_ids":["https://openalex.org/I159289790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008376932","display_name":"Mohan C. Vemuri","orcid":"https://orcid.org/0000-0002-4843-0814","observed_orcids":["https://orcid.org/0000-0002-4843-0814"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohan C. Vemuri","raw_affiliation_strings":["Childrens\u2019 Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens\u2019 Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110588507","display_name":"Gottipolu R. Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170558118","display_name":"Sri Venkateswara University","ror":"https://ror.org/05weahn72","country_code":"IN","type":"education","lineage":["https://openalex.org/I170558118"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gottipolu R. Reddy","raw_affiliation_strings":["SV University, Tirupati, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SV University, Tirupati, India","institution_ids":["https://openalex.org/I170558118"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083437336","display_name":"Suresh Challa","orcid":"https://orcid.org/0000-0002-7367-5848","observed_orcids":["https://orcid.org/0000-0002-7367-5848","https://orcid.org/0000-0002-8231-5334"]},"institutions":[{"id":"https://openalex.org/I53421241","display_name":"National Institute of Nutrition","ror":"https://ror.org/04970qw83","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I53421241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Challa Suresh","raw_affiliation_strings":["National Institute of Nutrition, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Nutrition, Hyderabad, India","institution_ids":["https://openalex.org/I53421241"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110179793"],"corresponding_institution_ids":["https://openalex.org/I159289790"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":0.724,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.67602141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"2","first_page":"396","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lead-toxicity","display_name":"lead toxicity","score":0.75},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6710000038146973},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.753000020980835},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7034525871276855},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6320643424987793},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6307681798934937},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5783695578575134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5551090240478516},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5454086661338806},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.545025110244751},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5372161269187927},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5303735733032227},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4545835256576538},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.44706466794013977},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4264538586139679},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.41717642545700073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4168819785118103},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4112027585506439},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40746626257896423},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3797060549259186},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30067020654678345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2705574035644531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23861080408096313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12946957349777222},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0831352174282074},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuro.2006.03.012","doi":"https://doi.org/10.1016/j.neuro.2006.03.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuro.2006.03.012","pdf_url":null,"source":{"id":"https://openalex.org/S115834843","display_name":"NeuroToxicology","issn_l":"0161-813X","issn":["0161-813X","1872-9711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroToxicology","raw_type":"journal-article"},{"id":"pmid:16678263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16678263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7016492031","display_name":"LEAD INDUCED CHANGES IN NITRIC OXIDE SIGNAL TRANSDUCTION","funder_award_id":"5r21gm060853-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7667119707","display_name":null,"funder_award_id":"GM 60853","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1918726675","https://openalex.org/W1966351239","https://openalex.org/W1976869489","https://openalex.org/W1978410273","https://openalex.org/W1982968106","https://openalex.org/W1997185588","https://openalex.org/W2004002095","https://openalex.org/W2005519211","https://openalex.org/W2009387294","https://openalex.org/W2018912133","https://openalex.org/W2028156020","https://openalex.org/W2029113391","https://openalex.org/W2036297310","https://openalex.org/W2043348076","https://openalex.org/W2045871851","https://openalex.org/W2054295934","https://openalex.org/W2065005507","https://openalex.org/W2080261487","https://openalex.org/W2082648762","https://openalex.org/W2096112783","https://openalex.org/W2100775283","https://openalex.org/W2127650618","https://openalex.org/W2131673170","https://openalex.org/W2151153503","https://openalex.org/W2152288875","https://openalex.org/W2164642963","https://openalex.org/W2165807863","https://openalex.org/W2432235438","https://openalex.org/W2475284264","https://openalex.org/W4405205335"],"related_works":["https://openalex.org/W2045644134","https://openalex.org/W2032281665","https://openalex.org/W1965230198","https://openalex.org/W7202025371","https://openalex.org/W1975211445","https://openalex.org/W2989751735","https://openalex.org/W7216989447","https://openalex.org/W1980782035","https://openalex.org/W2389388460","https://openalex.org/W1903028880"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}