{"id":"https://openalex.org/W1972123809","doi":"https://doi.org/10.1002/pros.21200","title":"Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: A case\u2013control study","display_name":"Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: A case\u2013control study","publication_year":2010,"publication_date":"2010-06-16","ids":{"openalex":"https://openalex.org/W1972123809","doi":"https://doi.org/10.1002/pros.21200","mag":"1972123809","pmid":"https://pubmed.ncbi.nlm.nih.gov/20564317"},"language":"en","primary_location":{"id":"doi:10.1002/pros.21200","doi":"https://doi.org/10.1002/pros.21200","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.21200","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040669872","display_name":"Mohammad Reza Safarinejad","orcid":"https://orcid.org/0000-0003-3055-5915","observed_orcids":["https://orcid.org/0000-0003-3055-5915"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Reza Safarinejad","raw_affiliation_strings":["Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran. safarinejad@unrc.ir","Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran. safarinejad@unrc.ir","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]},{"raw_affiliation_string":"Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086720058","display_name":"Nayyer Shafiei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nayyer Shafiei","raw_affiliation_strings":["Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111839256","display_name":"Shiva Safarinejad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shiva Safarinejad","raw_affiliation_strings":["Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040669872"],"corresponding_institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":4.4146,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.93500141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"70","issue":"15","first_page":"1645","last_page":"1657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylenetetrahydrofolate-reductase","display_name":"methylenetetrahydrofolate reductase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mthfr-a1298c-polymorphism","display_name":"MTHFR A1298C polymorphism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prostate-cancer-risk","display_name":"prostate cancer risk","score":0.9739999771118164},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6840000152587891},{"id":"https://openalex.org/keywords/high-grade-prostate-cancer","display_name":"high-grade prostate cancer","score":0.7070000171661377},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.9330000281333923},{"id":"https://openalex.org/keywords/total-homocysteine","display_name":"total homocysteine","score":0.9100000262260437},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.9079999923706055},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":1.0}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9561804533004761},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8323681354522705},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7150879502296448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7117679119110107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6148959398269653},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.5463346838951111},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5433810353279114},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5275185704231262},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5181030631065369},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.5066633820533752},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.48799389600753784},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4586823284626007},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.45525774359703064},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3635740876197815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1870887279510498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15606635808944702},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09008026123046875}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003538","descriptor_name":"Cystamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003538","descriptor_name":"Cystamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pros.21200","doi":"https://doi.org/10.1002/pros.21200","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.21200","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:20564317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20564317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W19867578","https://openalex.org/W23009779","https://openalex.org/W1690786713","https://openalex.org/W1820069114","https://openalex.org/W1954873734","https://openalex.org/W1963595709","https://openalex.org/W1964687425","https://openalex.org/W1966251853","https://openalex.org/W1967503767","https://openalex.org/W1969946826","https://openalex.org/W1976618369","https://openalex.org/W1977577913","https://openalex.org/W1979426291","https://openalex.org/W2004249914","https://openalex.org/W2011498006","https://openalex.org/W2016686641","https://openalex.org/W2017116286","https://openalex.org/W2025231171","https://openalex.org/W2029030998","https://openalex.org/W2029513761","https://openalex.org/W2030515524","https://openalex.org/W2031262735","https://openalex.org/W2045746568","https://openalex.org/W2058081517","https://openalex.org/W2058705683","https://openalex.org/W2059146749","https://openalex.org/W2066179736","https://openalex.org/W2074074282","https://openalex.org/W2090567861","https://openalex.org/W2092184430","https://openalex.org/W2094505351","https://openalex.org/W2098388063","https://openalex.org/W2106096585","https://openalex.org/W2107110101","https://openalex.org/W2128023080","https://openalex.org/W2130826348","https://openalex.org/W2131569634","https://openalex.org/W2133857505","https://openalex.org/W2136648615","https://openalex.org/W2136721576","https://openalex.org/W2137477400","https://openalex.org/W2141794685","https://openalex.org/W2144500318","https://openalex.org/W2144891453","https://openalex.org/W2147015883","https://openalex.org/W2159632720","https://openalex.org/W2161069925","https://openalex.org/W2161482535","https://openalex.org/W2164911583","https://openalex.org/W2165715420","https://openalex.org/W2183740206","https://openalex.org/W2184910961","https://openalex.org/W2277111680"],"related_works":["https://openalex.org/W2045746568","https://openalex.org/W2016686641","https://openalex.org/W2077122054","https://openalex.org/W4376508518","https://openalex.org/W2141794685","https://openalex.org/W2074056530","https://openalex.org/W2121563888","https://openalex.org/W2472250032","https://openalex.org/W2002146355","https://openalex.org/W2052355595"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,18,72],"hypothesized":[2],"that":[3,74,233],"genetic":[4],"polymorphisms":[5,22,237],"in":[6,38,88,132,213,243,250],"methylenetetrahydrofolate":[7],"reductase":[8],"(MTHFR)":[9],"gene":[10],"are":[11,259],"associated":[12,82,127,154,177],"with":[13,83,128,155,178,192,226],"prostate":[14,91,135,160,170,186,246],"cancer":[15,92,136,161,171,187],"risk.":[16],"METHODS:":[17],"genotyped":[19],"three":[20,235],"MTHFR":[21,76,236],"(C677T,":[23],"A1298C,":[24],"and":[25,27,34,45,68,78,101,115,195,219,254],"G1793A)":[26],"measured":[28],"serum":[29],"total":[30],"homocysteine":[31],"(tHcy),":[32],"folate,":[33,218],"vitamin":[35,220],"B12":[36,221],"levels":[37,215],"a":[39,129,240],"case-control":[40],"study":[41],"of":[42,90,122,134,149,184,216],"174":[43],"cases":[44,58],"348":[46],"normal":[47],"healthy":[48],"controls.":[49],"The":[50,118],"cancer-free":[51],"controls":[52],"were":[53,81,126,153],"frequency":[54],"matched":[55],"to":[56,112,261],"the":[57,75,113,146,173,193,223,244],"by":[59],"age":[60],"(\u00b12":[61],"years),":[62],"educational":[63],"level,":[64],"occupational":[65],"status,":[66],"ethnicity,":[67],"smoking":[69],"status.":[70],"RESULTS:":[71],"found":[73],"677TT":[77,174],"1298CC":[79],"genotypes":[80,121,148,197],"an":[84],"about":[85],"40%":[86],"reduction":[87,131],"risk":[89,133,158,183],"(adjusted":[93],"OR":[94,103],"=":[95,99,104,108,138,142,163,167,199,203,206],"0.59,":[96],"95%":[97,106,140,165,201],"CI":[98,107,141,166,202],"0.41-0.94,":[100],"adjusted":[102],"0.58,":[105],"0.32-0.91,":[109],"respectively)":[110],"compared":[111,191],"677CC,":[114],"1298AA":[116],"genotypes.":[117,228],"combined":[119],"variant":[120,147],"1298AC":[123],"+":[124,151],"677CC":[125,194],"30%":[130],"(OR":[137,162,198],"0.70;":[139],"0.53-0.79).":[143],"In":[144],"contrast,":[145],"1793GA":[150],"677CT":[152,196],"slightly":[156],"increased":[157],"for":[159],"1.64;":[164],"0.86-2.15).":[168],"Regarding":[169],"aggressiveness,":[172],"genotype":[175],"was":[176,209],"more":[179],"than":[180],"50%":[181],"decreased":[182],"high-grade":[185],"(Gleason":[188],"score":[189],">7)":[190],"0.35,":[200],"0.24-0.64;":[204],"P":[205],"0.001).":[207],"There":[208],"no":[210],"significant":[211],"difference":[212],"plasma":[214],"tHcy,":[217],"between":[222],"two":[224],"groups":[225],"any":[227],"CONCLUSION:":[229],"These":[230],"data":[231],"suggest":[232],"all":[234],"may":[238],"play":[239],"pivotal":[241],"role":[242],"developing":[245],"cancer.":[247],"Larger":[248],"studies":[249],"different":[251],"ethnic":[252],"populations":[253],"incorporating":[255],"dietary":[256],"folate":[257],"intake":[258],"needed":[260],"replicate":[262],"our":[263],"findings.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
