{"id":"https://openalex.org/W1972120620","doi":"https://doi.org/10.1021/bp970079k","title":"Capillary Electrophoresis in Biotechnology","display_name":"Capillary Electrophoresis in Biotechnology","publication_year":1997,"publication_date":"1997-10-07","ids":{"openalex":"https://openalex.org/W1972120620","doi":"https://doi.org/10.1021/bp970079k","mag":"1972120620","pmid":"https://pubmed.ncbi.nlm.nih.gov/9336986"},"language":"en","primary_location":{"id":"doi:10.1021/bp970079k","doi":"https://doi.org/10.1021/bp970079k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp970079k","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103459923","display_name":"Matthew E. Roche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.E. Roche","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA","Capillary Electrophoresis Laboratory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Capillary Electrophoresis Laboratory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111873607","display_name":"R.P. Oda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.P. Oda","raw_affiliation_strings":["Capillary Electrophoresis Laboratory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capillary Electrophoresis Laboratory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031563436","display_name":"James P. Landers","orcid":"https://orcid.org/0000-0002-9310-1796","observed_orcids":["https://orcid.org/0000-0002-9310-1796"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.P. Landers","raw_affiliation_strings":["Capillary Electrophoresis Laboratory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905","Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Capillary Electrophoresis Laboratory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031563436"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I170201317"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":2.7693,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.88228754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"5","first_page":"659","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capillary-electrophoresis","display_name":"capillary electrophoresis","score":1.0},{"id":"https://openalex.org/keywords/biotechnology-applications","display_name":"biotechnology applications","score":0.6019999980926514},{"id":"https://openalex.org/keywords/bioanalysis","display_name":"bioanalysis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/protein-separation","display_name":"protein separation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dna-separation","display_name":"DNA separation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/macromolecular-separation","display_name":"macromolecular separation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/electrophoretic-detection","display_name":"electrophoretic detection","score":0.7369999885559082},{"id":"https://openalex.org/keywords/solvent-reduction","display_name":"solvent reduction","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.884436845779419},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.8409806489944458},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.729899525642395},{"id":"https://openalex.org/C40250595","wikidata":"https://www.wikidata.org/wiki/Q185098","display_name":"Electrophoresis","level":2,"score":0.6066996455192566},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.601524293422699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.52684485912323},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.4404972195625305},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4024781286716461},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36500853300094604},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.33934104442596436},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.21386578679084778},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019075","descriptor_name":"Electrophoresis, Capillary","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bp970079k","doi":"https://doi.org/10.1021/bp970079k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp970079k","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},{"id":"pmid:9336986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9336986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology progress","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087654440","https://openalex.org/W4390170483","https://openalex.org/W2398721404","https://openalex.org/W4240729372","https://openalex.org/W7100096548","https://openalex.org/W7096829059","https://openalex.org/W2000867522","https://openalex.org/W7036143465","https://openalex.org/W7096603505","https://openalex.org/W2349552521"],"abstract_inverted_index":{"Capillary":[0],"electrophoresis":[1],"(CE)":[2],"is":[3],"a":[4,28,111],"versatile":[5],"micro/macroanalytical":[6],"technique":[7],"gaining":[8],"widespread":[9],"usage":[10,96],"for":[11,46,68],"the":[12,22,44,71,82,90,108,131,159],"separation":[13,50],"and":[14,43,84,97,125,139,145,155,157],"analysis":[15,57],"of":[16,24,30,51,70,86,92,104,110,114,130,135,162],"ionic":[17],"substances.":[18],"It":[19],"has":[20,147],"captured":[21],"attention":[23],"those":[25],"working":[26],"in":[27,61],"variety":[29],"arenas":[31],"focused":[32,148],"on":[33,149],"biologically-active":[34],"molecules.":[35],"Its":[36],"appealing":[37],"characteristics":[38,103],"include":[39,107],"unprecedented":[40],"mass":[41],"sensitivity":[42],"ability":[45],"precise,":[47],"automated":[48],"electrophoretic":[49,77],"microvolume":[52],"samples":[53],"with":[54],"relatively":[55],"short":[56],"times.":[58],"Such":[59],"versatility":[60],"bioanalysis":[62],"makes":[63],"it":[64],"an":[65],"inviting":[66],"replacement":[67],"some":[69,129],"labor-intensive,":[72],"time-consuming":[73],"methodologies":[74],"performed":[75],"via":[76],"gels.":[78],"Moreover,":[79],"CE":[80,143,163],"compliments":[81],"ease":[83],"speed":[85],"HPLC":[87],"while":[88],"eliminating":[89],"problem":[91],"excessive":[93],"solvent":[94],"volume":[95],"hazardous":[98],"waste":[99],"disposal.":[100],"Further":[101],"attractive":[102],"this":[105],"technology":[106],"analyses":[109],"diverse":[112],"spectrum":[113],"analytes,":[115],"ranging":[116],"from":[117],"small":[118],"organic":[119],"ions":[120],"to":[121,152],"macromolecular":[122],"protein":[123],"complexes":[124],"DNA.":[126],"While":[127],"combining":[128],"most":[132],"robust":[133],"aspects":[134],"traditional":[136],"electrophoresis,":[137],"chromatography,":[138],"capillary":[140],"technology,":[141],"recent":[142],"research":[144],"development":[146],"avenues":[150],"leading":[151],"improving":[153],"detection":[154],"understanding":[156],"employing":[158],"basic":[160],"chemistry":[161],"vis-a-vis":[164],"new":[165],"applications.":[166]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}