{"id":"https://openalex.org/W1972100007","doi":"https://doi.org/10.1016/j.neuroimage.2012.09.019","title":"Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA","display_name":"Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA","publication_year":2012,"publication_date":"2012-09-17","ids":{"openalex":"https://openalex.org/W1972100007","doi":"https://doi.org/10.1016/j.neuroimage.2012.09.019","mag":"1972100007","pmid":"https://pubmed.ncbi.nlm.nih.gov/22995777","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3540799"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2012.09.019","doi":"https://doi.org/10.1016/j.neuroimage.2012.09.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2012.09.019","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuroimage.2012.09.019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042229129","display_name":"Hsin-Hsien Yeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsin-Hsien Yeh","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035410232","display_name":"Mei Tian","orcid":"https://orcid.org/0000-0002-1587-2114","observed_orcids":["https://orcid.org/0000-0002-1587-2114"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Tian","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003551209","display_name":"Rainer Hinz","orcid":"https://orcid.org/0000-0002-7808-9207","observed_orcids":["https://orcid.org/0000-0002-7808-9207"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rainer Hinz","raw_affiliation_strings":["Wolfson Molecular Imaging Center, University of Manchester, Manchester, UK","University of Manchester\u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Molecular Imaging Center, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester\u00a0","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008249635","display_name":"Daniel P. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Young","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018907104","display_name":"Alexander Shavrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Shavrin","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084795242","display_name":"Uday Mukhapadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uday Mukhapadhyay","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110429927","display_name":"Leo G. Flores","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo G. Flores","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074278296","display_name":"Julius Balatoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julius Balatoni","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029337164","display_name":"Suren Soghomonyan","orcid":"https://orcid.org/0000-0001-5930-9051","observed_orcids":["https://orcid.org/0000-0001-5930-9051"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suren Soghomonyan","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100828792","display_name":"Hwan Jeong Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hwan J. Jeong","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061115590","display_name":"Ashutosh Pal","orcid":"https://orcid.org/0000-0003-3608-8481","observed_orcids":["https://orcid.org/0000-0003-3608-8481"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashutosh Pal","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020337852","display_name":"Rajesh Uthamanthil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Uthamanthil","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114858263","display_name":"James N. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James N. Jackson","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020494950","display_name":"Ryuichi Nishii","orcid":"https://orcid.org/0000-0002-2096-4611","observed_orcids":["https://orcid.org/0000-0002-2096-4611"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Nishii","raw_affiliation_strings":["Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","University of miyazaki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]},{"raw_affiliation_string":"University of miyazaki","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034839994","display_name":"Hiroshi Mizuma","orcid":"https://orcid.org/0000-0001-8970-9486","observed_orcids":["https://orcid.org/0000-0001-8970-9486"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Mizuma","raw_affiliation_strings":["Functional Probe Research Laboratory, RIKEN Center for Molecular Imaging Science, Kobe, Japan","RIKEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Probe Research Laboratory, RIKEN Center for Molecular Imaging Science, Kobe, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036006060","display_name":"Hirotaka Onoe","orcid":"https://orcid.org/0000-0001-8416-6259","observed_orcids":["https://orcid.org/0000-0001-8416-6259"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Onoe","raw_affiliation_strings":["Functional Probe Research Laboratory, RIKEN Center for Molecular Imaging Science, Kobe, Japan","RIKEN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Probe Research Laboratory, RIKEN Center for Molecular Imaging Science, Kobe, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"RIKEN","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041213463","display_name":"Shinya Kagawa","orcid":"https://orcid.org/0000-0001-5514-929X","observed_orcids":["https://orcid.org/0000-0001-5514-929X"]},"institutions":[{"id":"https://openalex.org/I4210158770","display_name":"Shiga General Hospital","ror":"https://ror.org/05kpy7q29","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158770"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Kagawa","raw_affiliation_strings":["Division of PET Imaging, Shiga Medical Center Research Institute, Moriyama, Japan","Shiga Medical Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of PET Imaging, Shiga Medical Center Research Institute, Moriyama, Japan","institution_ids":["https://openalex.org/I4210158770"]},{"raw_affiliation_string":"Shiga Medical Center Research Institute","institution_ids":["https://openalex.org/I4210158770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067101373","display_name":"Tatsuya Higashi","orcid":"https://orcid.org/0000-0002-8338-4737","observed_orcids":["https://orcid.org/0000-0002-8338-4737"]},"institutions":[{"id":"https://openalex.org/I4210158770","display_name":"Shiga General Hospital","ror":"https://ror.org/05kpy7q29","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158770"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Higashi","raw_affiliation_strings":["Division of PET Imaging, Shiga Medical Center Research Institute, Moriyama, Japan","Shiga Medical Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of PET Imaging, Shiga Medical Center Research Institute, Moriyama, Japan","institution_ids":["https://openalex.org/I4210158770"]},{"raw_affiliation_string":"Shiga Medical Center Research Institute","institution_ids":["https://openalex.org/I4210158770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051227977","display_name":"Nobuyoshi Fukumitsu","orcid":"https://orcid.org/0000-0003-2417-8199","observed_orcids":["https://orcid.org/0000-0003-2417-8199"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyoshi Fukumitsu","raw_affiliation_strings":["Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan","university of Tsukuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"university of Tsukuba","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064151398","display_name":"Mian M. Alauddin","orcid":"https://orcid.org/0000-0002-0954-3605","observed_orcids":["https://orcid.org/0000-0002-0954-3605"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mian Alauddin","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","Cancer Systems Imaging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Cancer Systems Imaging","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109233889","display_name":"William P. Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Tong","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053401725","display_name":"Karl Herholz","orcid":"https://orcid.org/0000-0002-8658-0151","observed_orcids":["https://orcid.org/0000-0002-8658-0151"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karl Herholz","raw_affiliation_strings":["Wolfson Molecular Imaging Center, University of Manchester, Manchester, UK","University of Manchester\u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wolfson Molecular Imaging Center, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester\u00a0","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037658628","display_name":"Juri George Gelovani","orcid":"https://orcid.org/0000-0002-8413-6161","observed_orcids":["https://orcid.org/0000-0002-8413-6161"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juri G. Gelovani","raw_affiliation_strings":["Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037658628"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":{"value":3540,"currency":"USD","value_usd":3540},"fwci":1.9948,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.86541256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":null,"first_page":"630","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7070000171661377},{"id":"https://openalex.org/keywords/pet-mri","display_name":"PET/MRI","score":0.7990000247955322},{"id":"https://openalex.org/keywords/pharmacodynamic-imaging","display_name":"pharmacodynamic imaging","score":0.6430000066757202},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.5260000228881836},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.6589999794960022},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.7950000166893005},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.5809999704360962},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6440246105194092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5042060613632202},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.49872565269470215},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3477633595466614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3404316306114197},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24610775709152222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1639431118965149},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15291115641593933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013382","descriptor_name":"Subtraction Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.neuroimage.2012.09.019","doi":"https://doi.org/10.1016/j.neuroimage.2012.09.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2012.09.019","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:22995777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22995777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/74a29e34-c494-444d-b92e-d0b12906693e","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/74a29e34-c494-444d-b92e-d0b12906693e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeh, H H, Tian, M, Hinz, R, Young, D, Shavrin, A, Mukhapadhyay, U, Flores, L G, Balatoni, J, Soghomonyan, S, Jeong, H J, Pal, A, Uthamanthil, R, Jackson, J N, Nishii, R, Mizuma, H, Onoe, H, Kagawa, S, Higashi, T, Fukumitsu, N, Alauddin, M, Tong, W, Herholz, K & Gelovani, J G 2013, 'Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA', NeuroImage, vol. 64, no. 1, pp. 630-639. https://doi.org/10.1016/j.neuroimage.2012.09.019","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3540799","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3540799/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/7f6259e1-069c-40f4-9c77-146aed62d937","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/22995777","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yeh, H H, Tian, M, Hinz, R, Young, D, Shavrin, A, Mukhapadhyay, U, Flores, L G, Balatoni, J, Soghomonyan, S, Jeong, H J, Pal, A, Uthamanthil, R, Jackson, J N, Nishii, R, Mizuma, H, Onoe, H, Kagawa, S, Higashi, T, Fukumitsu, N, Alauddin, M, Tong, W, Herholz, K & Gelovani, J G 2013, 'Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with (18)F-FAHA', NeuroImage, vol. 64, pp. 630-9. https://doi.org/10.1016/j.neuroimage.2012.09.019 S1053-8119(12)00929-9 [pii]","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2012.09.019","doi":"https://doi.org/10.1016/j.neuroimage.2012.09.019","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2012.09.019","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3577409558","display_name":"HDAC Class IIa specific PET radiotracers for PET imaging of CNS","funder_award_id":"RC2DA028912","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3786748327","display_name":"Development and Assessment of HDAC Targeted PET Imaging","funder_award_id":"23300361","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5748548061","display_name":"Involvement of social interaction deficits and histone modification in brain","funder_award_id":"22791013","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W47037482","https://openalex.org/W1973705376","https://openalex.org/W1976143339","https://openalex.org/W1978078858","https://openalex.org/W1978205433","https://openalex.org/W1979743501","https://openalex.org/W1981299552","https://openalex.org/W1982555880","https://openalex.org/W1987105053","https://openalex.org/W1989407684","https://openalex.org/W1993915316","https://openalex.org/W1996277745","https://openalex.org/W2002008745","https://openalex.org/W2003221870","https://openalex.org/W2008519619","https://openalex.org/W2008622025","https://openalex.org/W2013620670","https://openalex.org/W2018652402","https://openalex.org/W2020443792","https://openalex.org/W2020761570","https://openalex.org/W2033580181","https://openalex.org/W2037189426","https://openalex.org/W2043274685","https://openalex.org/W2045815014","https://openalex.org/W2052141092","https://openalex.org/W2052714177","https://openalex.org/W2056286291","https://openalex.org/W2058943159","https://openalex.org/W2064801613","https://openalex.org/W2065337304","https://openalex.org/W2069412667","https://openalex.org/W2071855613","https://openalex.org/W2074489888","https://openalex.org/W2075276600","https://openalex.org/W2080466389","https://openalex.org/W2086953891","https://openalex.org/W2091868956","https://openalex.org/W2095596307","https://openalex.org/W2098145833","https://openalex.org/W2099803844","https://openalex.org/W2104261628","https://openalex.org/W2111715042","https://openalex.org/W2121394973","https://openalex.org/W2128740541","https://openalex.org/W2130685024","https://openalex.org/W2135619784","https://openalex.org/W2143658931","https://openalex.org/W2148686253","https://openalex.org/W2151884322","https://openalex.org/W2152631096","https://openalex.org/W2155739395","https://openalex.org/W2162739635","https://openalex.org/W2167141364","https://openalex.org/W4285719527","https://openalex.org/W6601909576"],"related_works":["https://openalex.org/W836642015","https://openalex.org/W1979743501","https://openalex.org/W1018993806","https://openalex.org/W2092386655","https://openalex.org/W1107610895","https://openalex.org/W1004468826","https://openalex.org/W191326191","https://openalex.org/W2065437875","https://openalex.org/W7096290694","https://openalex.org/W1988030523"],"abstract_inverted_index":{"Epigenetic":[0],"modifications":[1],"mediated":[2],"by":[3],"histone":[4],"deacetylases":[5],"(HDACs)":[6],"play":[7],"important":[8],"roles":[9],"in":[10,24,32,59,89,113,150],"the":[11,33,40,71,83,90,106,127,151],"mechanisms":[12],"of":[13,29,42,48,74,82,86,102,108,110,129,131,144,146],"different":[14,114],"neurologic":[15],"diseases":[16],"and":[17,69,76,117,120],"HDAC":[18,49,67,132,147],"inhibitors":[19],"(HDACIs)":[20],"have":[21],"shown":[22],"promise":[23],"therapy.":[25],"However,":[26],"pharmacodynamic":[27],"profiles":[28],"many":[30],"HDACIs":[31],"brain":[34,91,103,115],"remain":[35],"largely":[36],"unknown":[37],"due":[38],"to":[39],"lack":[41],"validated":[43],"methods":[44],"for":[45],"noninvasive":[46],"imaging":[47,56],"expression-activity.":[50],"In":[51],"this":[52],"study,":[53],"dynamic":[54],"PET/CT":[55],"was":[57,92],"performed":[58,93],"4":[60],"rhesus":[61],"macaques":[62],"using":[63,94],"[(18)F]FAHA,":[64,75],"a":[65,95],"novel":[66],"substrate,":[68],"[(18)F]fluoroacetate,":[70],"major":[72],"radio-metabolite":[73],"fused":[77],"with":[78,124,138],"corresponding":[79],"MR":[80],"images":[81],"brain.":[84,152],"Quantification":[85],"[(18)F]FAHA":[87,125,139],"accumulation":[88],"customized":[96],"dual-tracer":[97],"pharmacokinetic":[98],"model.":[99],"Immunohistochemical":[100],"analyses":[101],"tissue":[104],"revealed":[105],"heterogeneity":[107],"expression":[109],"individual":[111],"HDACs":[112],"structures":[116],"cell":[118],"types":[119],"confirmed":[121],"that":[122],"PET/CT/MRI":[123,137],"reflects":[126],"level":[128],"expression-activity":[130],"class":[133],"IIa":[134],"enzymes.":[135],"Furthermore,":[136],"enabled":[140],"non-invasive,":[141],"quantitative":[142],"assessment":[143],"pharmacodynamics":[145],"inhibitor":[148],"SAHA":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}