{"id":"https://openalex.org/W1972084797","doi":"https://doi.org/10.1021/bi00075a012","title":"Structure of the human C6 gene","display_name":"Structure of the human C6 gene","publication_year":1993,"publication_date":"1993-06-22","ids":{"openalex":"https://openalex.org/W1972084797","doi":"https://doi.org/10.1021/bi00075a012","mag":"1972084797","pmid":"https://pubmed.ncbi.nlm.nih.gov/8512929"},"language":"en","primary_location":{"id":"doi:10.1021/bi00075a012","doi":"https://doi.org/10.1021/bi00075a012","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00075a012","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108357991","display_name":"Michael J. Hobart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. J. Hobart","raw_affiliation_strings":["MIP Unit, MRC Centre, Cambridge, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIP Unit, MRC Centre, Cambridge, U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111706568","display_name":"Barbara A. Fernie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Fernie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110966862","display_name":"Richard G. DiScipio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. G. DiScipio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9965,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87061521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"32","issue":"24","first_page":"6198","last_page":"6205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c9","display_name":"complement C9","score":0.7580000162124634},{"id":"https://openalex.org/keywords/terminal-complement-components","display_name":"terminal complement components","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.7229999899864197},{"id":"https://openalex.org/keywords/exon-intron-boundaries","display_name":"exon-intron boundaries","score":0.7749999761581421},{"id":"https://openalex.org/keywords/introns","display_name":"introns","score":0.609000027179718},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.7590000033378601},{"id":"https://openalex.org/keywords/protein-modules","display_name":"protein modules","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gene-evolution","display_name":"gene evolution","score":0.6830000281333923},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.746066153049469},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.6447687149047852},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.6052919626235962},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6021484136581421},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5836068987846375},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.46063506603240967},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3513360619544983},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.34675490856170654},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003183","descriptor_name":"Complement C6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003184","descriptor_name":"Complement C7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00075a012","doi":"https://doi.org/10.1021/bi00075a012","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00075a012","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:8512929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8512929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1873872968","display_name":null,"funder_award_id":"AI22 166","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6244156165","display_name":"STRUCTURE AND REGULATION OF LIVER ACUTE PHASE GENES","funder_award_id":"5r01ai022166-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1488927032","https://openalex.org/W1543417979","https://openalex.org/W1562626508","https://openalex.org/W1587809300","https://openalex.org/W1655857822","https://openalex.org/W1964365888","https://openalex.org/W1971992367","https://openalex.org/W1988860781","https://openalex.org/W1989275407","https://openalex.org/W1989336091","https://openalex.org/W1995420892","https://openalex.org/W1996616758","https://openalex.org/W1997952082","https://openalex.org/W1999668682","https://openalex.org/W2009310436","https://openalex.org/W2011313125","https://openalex.org/W2014669590","https://openalex.org/W2021152296","https://openalex.org/W2021748618","https://openalex.org/W2027807422","https://openalex.org/W2032118018","https://openalex.org/W2033131060","https://openalex.org/W2037170193","https://openalex.org/W2052356760","https://openalex.org/W2054723031","https://openalex.org/W2056296764","https://openalex.org/W2056581438","https://openalex.org/W2059626007","https://openalex.org/W2063420993","https://openalex.org/W2063450941","https://openalex.org/W2066825643","https://openalex.org/W2079291696","https://openalex.org/W2081215683","https://openalex.org/W2138270253","https://openalex.org/W2142750211","https://openalex.org/W2144634347","https://openalex.org/W2155826759","https://openalex.org/W2157713969","https://openalex.org/W2177078605","https://openalex.org/W2282432068","https://openalex.org/W2394503922","https://openalex.org/W2411690085"],"related_works":["https://openalex.org/W1552621440","https://openalex.org/W1488927032","https://openalex.org/W1964365888","https://openalex.org/W1543417979","https://openalex.org/W2013647511","https://openalex.org/W64969025","https://openalex.org/W1130398108","https://openalex.org/W1766322808","https://openalex.org/W2038699240","https://openalex.org/W2061769600"],"abstract_inverted_index":{"The":[0],"terminal":[1,130],"components":[2,132],"of":[3,24,31,76,86,88,92,96,107,128,144,150],"the":[4,46,60,72,77,84,89,108,114,126,129,139,164,167],"complement":[5,131],"system":[6],"(C6-C9)":[7],"are":[8,27,40,51,75],"related":[9],"proteins,":[10,22],"differing":[11],"in":[12,36,45,68,153],"size":[13],"and":[14,48,94,137,158],"complexity.":[15],"They":[16],"seem":[17],"to":[18,112,155,166],"be":[19],"typical":[20],"mosaic":[21,38],"composed":[23],"modules":[25],"which":[26],"homologous":[28],"with":[29,100],"parts":[30],"other":[32],"proteins.":[33],"Individual":[34],"elements":[35,110],"a":[37,54,120,145],"protein":[39,109,147],"often":[41,66],"bounded":[42],"by":[43],"introns":[44],"gene,":[47],"where":[49],"they":[50],"duplicated":[52],"within":[53,59],"polypeptide,":[55],"partial":[56],"gene":[57,61,156],"duplication":[58],"is":[62,65,149],"responsible.":[63],"It":[64],"found":[67],"such":[69],"genes":[70,127,161],"that":[71,142,159],"intron/exon":[73],"boundaries":[74,85],"class":[78],"1":[79],"type.":[80],"We":[81],"have":[82],"examined":[83],"17":[87],"18":[90],"exons":[91],"C6":[93],"five":[95],"C7.":[97],"When":[98],"considered":[99],"published":[101],"data":[102,118],"for":[103,125],"C9,":[104],"only":[105],"one":[106],"appears":[111],"follow":[113],"conventional":[115],"pattern.":[116],"These":[117],"suggest":[119],"more":[121],"complex":[122],"evolutionary":[123],"history":[124],"than":[133],"had":[134],"been":[135],"anticipated":[136],"challenge":[138],"notions":[140],"both":[141],"discovery":[143],"recognized":[146],"module":[148],"predictive":[151],"value":[152],"relation":[154],"structure":[157],"these":[160],"evolved":[162],"from":[163],"simple":[165],"complex.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
