{"id":"https://openalex.org/W1972074907","doi":"https://doi.org/10.1006/abbi.1996.0509","title":"Expression, Activation, and Processing of the Recombinant Snake Venom Metalloproteinase, Pro-Atrolysin E","display_name":"Expression, Activation, and Processing of the Recombinant Snake Venom Metalloproteinase, Pro-Atrolysin E","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W1972074907","doi":"https://doi.org/10.1006/abbi.1996.0509","mag":"1972074907","pmid":"https://pubmed.ncbi.nlm.nih.gov/8914925"},"language":"en","primary_location":{"id":"doi:10.1006/abbi.1996.0509","doi":"https://doi.org/10.1006/abbi.1996.0509","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abbi.1996.0509","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111940573","display_name":"Ken\u2010ichi Shimokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken-ichi Shimokawa","raw_affiliation_strings":["Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA","Department of Microbiology University of Virginia Health Sciences Center Charlottesville, Virginia 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Microbiology University of Virginia Health Sciences Center Charlottesville, Virginia 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067231208","display_name":"Li-Guo Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Guo Jia","raw_affiliation_strings":["Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377891","display_name":"Xiaoming Wang","orcid":"https://orcid.org/0000-0002-6473-1297","observed_orcids":["https://orcid.org/0000-0002-6473-1297"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Ming Wang","raw_affiliation_strings":["Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041069370","display_name":"Jay W. Fox","orcid":"https://orcid.org/0000-0003-4600-1132","observed_orcids":["https://orcid.org/0000-0003-4600-1132"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay W. Fox","raw_affiliation_strings":["Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041069370"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":1.3225,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.79179536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"335","issue":"2","first_page":"283","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crotalus-atrox","display_name":"Crotalus atrox","score":0.8389999866485596},{"id":"https://openalex.org/keywords/snake-venom-metalloproteinases","display_name":"snake venom metalloproteinases","score":0.9570000171661377},{"id":"https://openalex.org/keywords/zymogen-activation","display_name":"zymogen activation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/disintegrin-domain","display_name":"disintegrin domain","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hemorrhagic-toxin","display_name":"hemorrhagic toxin","score":0.7440000176429749},{"id":"https://openalex.org/keywords/autoactivation","display_name":"self-activation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/polyclonal-antibodies","display_name":"polyclonal antibodies","score":0.6259999871253967},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.9534760117530823},{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.8734660148620605},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.7806884050369263},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.7679276466369629},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.7473447322845459},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6748340129852295},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.6442458629608154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.640564501285553},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6378870606422424},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.587835431098938},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5079358220100403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.501025915145874},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.46641266345977783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33984795212745667},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33660441637039185},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15345337986946106},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07061076164245605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017839","descriptor_name":"Crotalus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/abbi.1996.0509","doi":"https://doi.org/10.1006/abbi.1996.0509","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abbi.1996.0509","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:8914925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8914925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5219725264","display_name":"ANTITHROMBOTIC DISINTEGRIN DOMAIN IN HEMORRHAGIC TOXINS","funder_award_id":"R01GM049042","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7050190894","display_name":null,"funder_award_id":"GM49042","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991530649","https://openalex.org/W1984429547","https://openalex.org/W2262509293","https://openalex.org/W7160266249","https://openalex.org/W2032363114","https://openalex.org/W2088695010","https://openalex.org/W3021252707","https://openalex.org/W2042965506","https://openalex.org/W2092990013","https://openalex.org/W7203467842"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
