{"id":"https://openalex.org/W1972049643","doi":"https://doi.org/10.1016/0005-2736(93)90159-w","title":"Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics","display_name":"Polycation-induced enhancement of epithelial paracellular permeability is independent of tight junctional characteristics","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W1972049643","doi":"https://doi.org/10.1016/0005-2736(93)90159-w","mag":"1972049643","pmid":"https://pubmed.ncbi.nlm.nih.gov/8499468"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2736(93)90159-w","doi":"https://doi.org/10.1016/0005-2736(93)90159-w","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2736(93)90159-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088608149","display_name":"Gordon T.A. McEwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gordon T.A. McEwan","raw_affiliation_strings":["Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103517000","display_name":"Mark A. Jepson","orcid":"https://orcid.org/0000-0002-0015-2413","observed_orcids":["https://orcid.org/0000-0002-0015-2413"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark A. Jepson","raw_affiliation_strings":["Gastrointestinal Drug Delivery Research Centre, Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Delivery Research Centre, Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050726535","display_name":"Barry Hugo Hirst","orcid":"https://orcid.org/0000-0001-6117-7908","observed_orcids":["https://orcid.org/0000-0001-6117-7908"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barry H. Hirst","raw_affiliation_strings":["Gastrointestinal Drug Delivery Research Centre, Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Delivery Research Centre, Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113928805","display_name":"Nicholas L. Simmons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas L. Simmons","raw_affiliation_strings":["Gastrointestinal Drug Delivery Research Centre, Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Delivery Research Centre, Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088608149"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":1.3855,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.78746243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1148","issue":"1","first_page":"51","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.9369999766349792},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9480000138282776},{"id":"https://openalex.org/keywords/poly-l-lysine","display_name":"poly-L-lysine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/transepithelial-conductance","display_name":"transepithelial conductance","score":0.921999990940094},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.8370000123977661},{"id":"https://openalex.org/keywords/zonula-occludens","display_name":"zonula occludens","score":0.8399999737739563},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.828000009059906},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.7699999809265137},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.9733139276504517},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.9316058158874512},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.5692068338394165},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5682042837142944},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.5461252331733704},{"id":"https://openalex.org/C51872919","wikidata":"https://www.wikidata.org/wiki/Q420863","display_name":"Claudin","level":3,"score":0.48863106966018677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.469390332698822},{"id":"https://openalex.org/C28938303","wikidata":"https://www.wikidata.org/wiki/Q17122952","display_name":"Transepithelial potential difference","level":4,"score":0.4604173004627228},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.4555164873600006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4543958008289337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34006965160369873},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.23401561379432678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20369374752044678},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.157065749168396},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.0719727873802185},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.06265515089035034}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007444","descriptor_name":"Inulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2736(93)90159-w","doi":"https://doi.org/10.1016/0005-2736(93)90159-w","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2736(93)90159-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},{"id":"pmid:8499468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8499468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W52706039","https://openalex.org/W1546734353","https://openalex.org/W1978752146","https://openalex.org/W1982857431","https://openalex.org/W1998180603","https://openalex.org/W2021906804","https://openalex.org/W2026536490","https://openalex.org/W2035171875","https://openalex.org/W2042315603","https://openalex.org/W2047500895","https://openalex.org/W2048423492","https://openalex.org/W2052763113","https://openalex.org/W2053407380","https://openalex.org/W2059843635","https://openalex.org/W2066718755","https://openalex.org/W2073862596","https://openalex.org/W2104373189","https://openalex.org/W2121386922","https://openalex.org/W2130352424","https://openalex.org/W2148250428","https://openalex.org/W2155579605","https://openalex.org/W2204214583","https://openalex.org/W2411019228","https://openalex.org/W2414277416"],"related_works":["https://openalex.org/W3156915710","https://openalex.org/W1548725377","https://openalex.org/W7208220379","https://openalex.org/W3133557010","https://openalex.org/W2013260602","https://openalex.org/W2162927541","https://openalex.org/W2148504803","https://openalex.org/W1974463950","https://openalex.org/W2133940096","https://openalex.org/W2085436600"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}