{"id":"https://openalex.org/W1972039711","doi":"https://doi.org/10.1136/adc.65.4.407","title":"Treatment of acute, episodic asthma in preschool children using intermittent high dose inhaled steroids at home.","display_name":"Treatment of acute, episodic asthma in preschool children using intermittent high dose inhaled steroids at home.","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W1972039711","doi":"https://doi.org/10.1136/adc.65.4.407","mag":"1972039711","pmid":"https://pubmed.ncbi.nlm.nih.gov/2189367","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1792186"},"language":"en","primary_location":{"id":"doi:10.1136/adc.65.4.407","doi":"https://doi.org/10.1136/adc.65.4.407","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.65.4.407","pdf_url":"https://adc.bmj.com/content/archdischild/65/4/407.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://adc.bmj.com/content/archdischild/65/4/407.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111979562","display_name":"N M Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N M Wilson","raw_affiliation_strings":["Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067954882","display_name":"Michael A Silverman","orcid":"https://orcid.org/0000-0001-6967-4917","observed_orcids":["https://orcid.org/0000-0001-6967-4917"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Silverman","raw_affiliation_strings":["Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London","institution_ids":["https://openalex.org/I2801748203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801748203"],"apc_list":null,"apc_paid":null,"fwci":2.958,"has_fulltext":true,"cited_by_count":173,"citation_normalized_percentile":{"value":0.91447995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65","issue":"4","first_page":"407","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma-exacerbation","display_name":"acute asthma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.9860000014305115},{"id":"https://openalex.org/keywords/beclomethasone-dipropionate","display_name":"beclomethasone dipropionate","score":1.0},{"id":"https://openalex.org/keywords/home-treatment","display_name":"home treatment","score":0.6579999923706055},{"id":"https://openalex.org/keywords/metered-dose-inhaler","display_name":"MDI","score":0.8479999899864197},{"id":"https://openalex.org/keywords/parental-preferences","display_name":"parental preferences","score":0.5870000123977661},{"id":"https://openalex.org/keywords/asthma-severity","display_name":"asthma severity","score":0.46700000762939453},{"id":"https://openalex.org/keywords/symptom-scores","display_name":"symptom scores","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9604977369308472},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7363024353981018},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7237756848335266},{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.6823511123657227},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.5256494283676147},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4818783700466156},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44375577569007874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21183940768241882},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001507","descriptor_name":"Beclomethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001507","descriptor_name":"Beclomethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006701","descriptor_name":"Home Nursing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/adc.65.4.407","doi":"https://doi.org/10.1136/adc.65.4.407","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.65.4.407","pdf_url":"https://adc.bmj.com/content/archdischild/65/4/407.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1792186","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1792186","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Dis Child","raw_type":"Text"},{"id":"pmid:2189367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2189367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of disease in childhood","raw_type":"Clinical Trial"},{"id":"mag:2186095880","doi":null,"is_oa":false,"landing_page_url":"https://adc.bmj.com/content/65/4/407.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1136/adc.65.4.407","doi":"https://doi.org/10.1136/adc.65.4.407","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.65.4.407","pdf_url":"https://adc.bmj.com/content/archdischild/65/4/407.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1972039711.pdf","grobid_xml":"https://content.openalex.org/works/W1972039711.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1499804004","https://openalex.org/W1901267355","https://openalex.org/W1987930135","https://openalex.org/W1989150058","https://openalex.org/W1991559037","https://openalex.org/W2046688069","https://openalex.org/W2073024624","https://openalex.org/W2076365047","https://openalex.org/W2078919868","https://openalex.org/W2151364494","https://openalex.org/W2156660340","https://openalex.org/W2161212285","https://openalex.org/W2163643342","https://openalex.org/W2240915743","https://openalex.org/W2317157161","https://openalex.org/W6682754256"],"related_works":["https://openalex.org/W2331406330","https://openalex.org/W2798252374","https://openalex.org/W2141672817","https://openalex.org/W2002391167","https://openalex.org/W2102005002","https://openalex.org/W2136284829","https://openalex.org/W2030827695","https://openalex.org/W2418633705","https://openalex.org/W2148217477","https://openalex.org/W1956202080"],"abstract_inverted_index":{"In":[0],"a":[1,157],"double":[2],"blind,":[3],"controlled":[4],"trial,":[5],"the":[6,49,100,112,123,127,145],"effect":[7],"of":[8,37,52,67,96,103,126,147],"high":[9,136],"dose":[10,24,137],"beclomethasone":[11,139],"dipropionate":[12,140],"(750":[13],"micrograms":[14],"three":[15],"times":[16],"daily":[17],"for":[18,58],"five":[19],"days)":[20],"administered":[21],"by":[22,72,132],"metered":[23],"inhaler":[25],"and":[26,88,119],"valved":[27],"spacer,":[28],"was":[29,61,94],"compared":[30],"with":[31],"placebo,":[32],"during":[33],"70":[34],"paired":[35],"episodes":[36,104],"acute":[38,148],"asthma":[39,150],"in":[40,86,105,110,143,151],"24":[41],"preschool":[42,152],"children.":[43],"Treatment":[44],"commenced":[45],"at":[46,48],"home":[47],"first":[50,124],"sign":[51],"an":[53],"attack.":[54],"Parents'":[55],"blind":[56],"preference":[57],"active":[59,87,113,133],"treatment":[60],"significant.":[62],"Data":[63],"from":[64,99],"17":[65],"pairs":[66,102],"treatment,":[68],"however,":[69],"were":[70,129],"affected":[71],"interventions":[73],"such":[74],"as":[75],"hospital":[76],"admission":[77],"or":[78,114],"oral":[79],"corticosteroid":[80],"treatment.":[81,116,134],"These":[82],"events":[83],"occurred":[84,109],"similarly":[85],"control":[89],"periods.":[90],"An":[91],"intrasubject":[92],"comparison":[93],"made":[95],"diary":[97],"scores":[98],"18":[101],"which":[106],"no":[107],"intervention":[108],"either":[111],"placebo":[115],"Both":[117],"daytime":[118],"night":[120],"symptoms":[121],"over":[122],"week":[125],"attack":[128],"significantly":[130],"reduced":[131],"Intermittent":[135],"inhaled":[138],"is":[141],"beneficial":[142],"modifying":[144],"severity":[146],"episodic":[149],"children":[153],"able":[154],"to":[155],"use":[156],"spacer":[158],"device.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}