{"id":"https://openalex.org/W1971989355","doi":"https://doi.org/10.1515/cclm.2007.103","title":"The c.\u2013292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective","display_name":"The c.\u2013292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1971989355","doi":"https://doi.org/10.1515/cclm.2007.103","mag":"1971989355","pmid":"https://pubmed.ncbi.nlm.nih.gov/17439326"},"language":"en","primary_location":{"id":"doi:10.1515/cclm.2007.103","doi":"https://doi.org/10.1515/cclm.2007.103","is_oa":false,"landing_page_url":"https://doi.org/10.1515/cclm.2007.103","pdf_url":null,"source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemical Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.zora.uzh.ch/id/eprint/15994/9/Wittwer_Hersberger_ClinChemLabM_07V.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041524809","display_name":"Jonas Wittwer","orcid":"https://orcid.org/0000-0002-8590-2657","observed_orcids":["https://orcid.org/0000-0002-8590-2657"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jonas Wittwer","raw_affiliation_strings":["Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035359530","display_name":"Mathias Bayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Bayer","raw_affiliation_strings":["Department of Food Chemistry, J.W. Goethe-University, Biocenter, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Chemistry, J.W. Goethe-University, Biocenter, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105779940","display_name":"Armin Mosandl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Armin Mosandl","raw_affiliation_strings":["Department of Food Chemistry, J.W. Goethe-University, Biocenter, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Chemistry, J.W. Goethe-University, Biocenter, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110090283","display_name":"J\u00f6rg Muntwyler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Muntwyler","raw_affiliation_strings":["Cardiovascular Center Division of Cardiology, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Center Division of Cardiology, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029425739","display_name":"Martin Hersberger","orcid":"https://orcid.org/0000-0002-4472-329X","observed_orcids":["https://orcid.org/0000-0002-4472-329X"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin Hersberger","raw_affiliation_strings":["Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":1.588,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78129236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"4","first_page":"487","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.9810000061988831},{"id":"https://openalex.org/keywords/15-lipoxygenase-1","display_name":"15-lipoxygenase-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.8180000185966492},{"id":"https://openalex.org/keywords/15-s-hete","display_name":"15(S)-HETE","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.7770000100135803},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.671999990940094},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.652999997138977},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2778403015","wikidata":"https://www.wikidata.org/wiki/Q1404923","display_name":"Reticulocyte","level":4,"score":0.8104139566421509},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.5683807134628296},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.5224370360374451},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4719720780849457},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45896199345588684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38869351148605347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38752123713493347},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37684303522109985},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3706907033920288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3210996091365814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2557469606399536},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1472240388393402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1441909372806549},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1274547278881073},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.10797208547592163}],"mesh":[{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1515/cclm.2007.103","doi":"https://doi.org/10.1515/cclm.2007.103","is_oa":false,"landing_page_url":"https://doi.org/10.1515/cclm.2007.103","pdf_url":null,"source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemical Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:17439326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17439326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry and laboratory medicine","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:15994","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/15994/9/Wittwer_Hersberger_ClinChemLabM_07V.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/15994/9/Wittwer_Hersberger_ClinChemLabM_07V.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wittwer, J; Bayer, M; Mosandl, A; Muntwyler, J; Hersberger, M (2007). The c.-292C&gt;T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective. Clinical Chemistry and Laboratory Medicine, 45(4):487-492.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doc.rero.ch:303367","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/303367/files/cclm.2007.103.pdf","pdf_url":"http://doc.rero.ch/record/303367/files/cclm.2007.103.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/40307","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/40307","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wittwer, J., Bayer, M., Mosandl, A., Muntwyler, J., & Hersberger, M. (2007). The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective. Clinical Chemistry and Laboratory Medicine, 45, 487\u2013492. https://doi.org/10.1515/CCLM.2007.103","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-15994","doi":"https://doi.org/10.5167/uzh-15994","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-15994","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:15994","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/15994/9/Wittwer_Hersberger_ClinChemLabM_07V.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/15994/9/Wittwer_Hersberger_ClinChemLabM_07V.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wittwer, J; Bayer, M; Mosandl, A; Muntwyler, J; Hersberger, M (2007). The c.-292C&gt;T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective. Clinical Chemistry and Laboratory Medicine, 45(4):487-492.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320325144","display_name":"EMDO Stiftung","ror":"https://ror.org/04fb2bf88"},{"id":"https://openalex.org/F4320325738","display_name":"Universit\u00e4tsspital Z\u00fcrich","ror":"https://ror.org/01462r250"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W165150806","https://openalex.org/W1505047300","https://openalex.org/W1517088677","https://openalex.org/W1581644356","https://openalex.org/W1976616659","https://openalex.org/W2002585927","https://openalex.org/W2022120020","https://openalex.org/W2024183861","https://openalex.org/W2034937689","https://openalex.org/W2065376096","https://openalex.org/W2068210705","https://openalex.org/W2074203890","https://openalex.org/W2091327138","https://openalex.org/W2094134864","https://openalex.org/W2107958649","https://openalex.org/W2132337491","https://openalex.org/W2149303684","https://openalex.org/W2151840463","https://openalex.org/W2159226443","https://openalex.org/W2163289904","https://openalex.org/W4242272577"],"related_works":["https://openalex.org/W2062843573","https://openalex.org/W2002585927","https://openalex.org/W2081669377","https://openalex.org/W2065760033","https://openalex.org/W2766003463","https://openalex.org/W2734432456","https://openalex.org/W2160204754","https://openalex.org/W2029969777","https://openalex.org/W2006185943","https://openalex.org/W1974052090"],"abstract_inverted_index":{"BACKGROUND:":[0],"Reticulocyte-type":[1],"15-lipoxygenase-1":[2],"(ALOX15)":[3],"has":[4],"anti-inflammatory":[5],"and":[6,9,18,61,90,170],"inflammatory":[7],"effects":[8],"is":[10],"implicated":[11],"in":[12,32,46,66,118,135,168],"the":[13,23,47,57,76,92,175],"development":[14],"of":[15],"asthma,":[16],"arthritis":[17],"atherosclerosis.":[19,149],"Previously,":[20],"we":[21,85,114],"screened":[22],"human":[24],"ALOX15":[25,33,48,63,83,156],"gene":[26],"for":[27,56],"variations":[28],"because":[29],"genetic":[30],"variability":[31],"might":[34],"influence":[35],"these":[36],"diseases.":[37],"We":[38],"found":[39],"a":[40,52,119,143],"C>T":[41],"substitution":[42],"at":[43],"position":[44],"c.-292":[45],"promoter":[49],"that":[50,154],"created":[51],"novel":[53],"binding":[54],"site":[55],"transcription":[58],"factor":[59],"SPI1":[60],"increased":[62,155],"mRNA":[64,78],"levels":[65,79],"monocytes":[67],"from":[68],"c.-292CT":[69],"heterozygous":[70,136],"volunteers.":[71],"METHODS:":[72],"To":[73,102],"test":[74,103],"whether":[75,104],"higher":[77,82,132],"led":[80],"to":[81,145],"activity,":[84],"performed":[86],"an":[87,166],"activity":[88,134,157],"assay":[89],"measured":[91],"arachidonic":[93],"acid":[94,97],"metabolite":[95],"15(S)-hydroxy-eicosatetraenoic":[96],"[15(S)-HETE]":[98],"by":[99,165,172],"HPLC":[100],"analysis.":[101],"this":[105,139],"polymorphism":[106,128,140],"was":[107,129],"associated":[108,130],"with":[109,131],"coronary":[110],"artery":[111],"disease":[112],"(CAD),":[113],"investigated":[115],"its":[116,173],"association":[117],"case-control":[120],"study":[121],"involving":[122],"498":[123],"Caucasians.":[124],"RESULTS:":[125],"The":[126],"c.-292C>T":[127],"enzyme":[133],"carriers.":[137],"Intriguingly,":[138],"also":[141],"showed":[142],"tendency":[144],"be":[146,163],"protective":[147],"against":[148],"CONCLUSIONS:":[150],"These":[151],"results":[152],"suggest":[153],"may":[158],"attenuate":[159],"inflammation,":[160],"which":[161],"could":[162],"caused":[164],"increase":[167],"15(S)-HETE":[169],"eventually":[171],"metabolites,":[174],"lipoxins.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
