{"id":"https://openalex.org/W1971887836","doi":"https://doi.org/10.1038/ki.1994.265","title":"Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats","display_name":"Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W1971887836","doi":"https://doi.org/10.1038/ki.1994.265","mag":"1971887836","pmid":"https://pubmed.ncbi.nlm.nih.gov/7933842"},"language":"en","primary_location":{"id":"doi:10.1038/ki.1994.265","doi":"https://doi.org/10.1038/ki.1994.265","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1994.265","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/ki.1994.265","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012371496","display_name":"Yasushi Tsuboi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Tsuboi","raw_affiliation_strings":["Department of Medicine, Jichi Medical School, Tochigi, Japan","Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112187675","display_name":"San-e Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"San-e Ishikawa","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089479862","display_name":"Genro Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Genro Fujisawa","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014484265","display_name":"Koji Okada","orcid":"https://orcid.org/0000-0002-4317-8808","observed_orcids":["https://orcid.org/0000-0002-4317-8808"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Okada","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110703922","display_name":"Toshikazu Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikazu Saito","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146500386"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.0942,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.91106095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"46","issue":"1","first_page":"237","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opc-31260","display_name":"OPC-31260","score":0.972000002861023},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/water-excretion","display_name":"water excretion","score":0.7360000014305115},{"id":"https://openalex.org/keywords/urine-osmolality","display_name":"urine osmolality","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.7870000004768372},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-cirrhosis","display_name":"carbon tetrachloride-induced cirrhosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vasopressin-receptor-antagonism","display_name":"vasopressin receptor antagonism","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2778534349","wikidata":"https://www.wikidata.org/wiki/Q7900633","display_name":"Urine osmolality","level":3,"score":0.7415586709976196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7268548607826233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7243265509605408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6378094553947449},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.531017005443573},{"id":"https://openalex.org/C14705128","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmole","level":2,"score":0.5307244062423706},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.48170095682144165},{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.44074803590774536},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.4248088002204895},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.420177161693573},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.4147787094116211},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.33960622549057007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3232674300670624}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/ki.1994.265","doi":"https://doi.org/10.1038/ki.1994.265","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1994.265","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:7933842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7933842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/ki.1994.265","doi":"https://doi.org/10.1038/ki.1994.265","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1994.265","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W92644028","https://openalex.org/W105014381","https://openalex.org/W564549653","https://openalex.org/W1460766508","https://openalex.org/W1727785519","https://openalex.org/W1849870532","https://openalex.org/W1886401007","https://openalex.org/W1905795974","https://openalex.org/W1968129466","https://openalex.org/W1970444261","https://openalex.org/W1975433215","https://openalex.org/W1976942568","https://openalex.org/W1981910968","https://openalex.org/W1981972230","https://openalex.org/W1991522711","https://openalex.org/W1996996770","https://openalex.org/W1999322668","https://openalex.org/W1999334442","https://openalex.org/W2006693876","https://openalex.org/W2016969540","https://openalex.org/W2025705442","https://openalex.org/W2033420791","https://openalex.org/W2036487592","https://openalex.org/W2037749453","https://openalex.org/W2045520532","https://openalex.org/W2048384070","https://openalex.org/W2057380338","https://openalex.org/W2057640040","https://openalex.org/W2060338318","https://openalex.org/W2061628960","https://openalex.org/W2070715552","https://openalex.org/W2072534994","https://openalex.org/W2073836921","https://openalex.org/W2085350145","https://openalex.org/W2089142602","https://openalex.org/W2094807680","https://openalex.org/W2105920220","https://openalex.org/W2118224724","https://openalex.org/W2158437483","https://openalex.org/W2268092481","https://openalex.org/W2276557084","https://openalex.org/W2307155829","https://openalex.org/W2311309180","https://openalex.org/W2328760665","https://openalex.org/W2949735424","https://openalex.org/W4252706829","https://openalex.org/W4407006046","https://openalex.org/W4407023406","https://openalex.org/W6639651275","https://openalex.org/W6691344535","https://openalex.org/W6693733721"],"related_works":["https://openalex.org/W2103209316","https://openalex.org/W2346028701","https://openalex.org/W2104241768","https://openalex.org/W2132332398","https://openalex.org/W1914404543","https://openalex.org/W1727785519","https://openalex.org/W7097065747","https://openalex.org/W2048384070","https://openalex.org/W2420240683","https://openalex.org/W2019207476"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}