{"id":"https://openalex.org/W1971788694","doi":"https://doi.org/10.1002/pd.2250","title":"Prenatal screening and diagnosis of neural tube defects","display_name":"Prenatal screening and diagnosis of neural tube defects","publication_year":2009,"publication_date":"2009-03-19","ids":{"openalex":"https://openalex.org/W1971788694","doi":"https://doi.org/10.1002/pd.2250","mag":"1971788694","pmid":"https://pubmed.ncbi.nlm.nih.gov/19301349"},"language":"en","primary_location":{"id":"doi:10.1002/pd.2250","doi":"https://doi.org/10.1002/pd.2250","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pd.2250","pdf_url":null,"source":{"id":"https://openalex.org/S171405753","display_name":"Prenatal Diagnosis","issn_l":"0197-3851","issn":["0197-3851","1097-0223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal Diagnosis","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1971788694"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113709738","display_name":"Martin Cameron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Cameron","raw_affiliation_strings":["Fetal Medicine Department, Leazes Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fetal Medicine Department, Leazes Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031059415","display_name":"Paul Moran","orcid":"https://orcid.org/0000-0002-9257-8699","observed_orcids":["https://orcid.org/0000-0002-9257-8699"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul Moran","raw_affiliation_strings":["Fetal Medicine Department, Leazes Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fetal Medicine Department, Leazes Wing, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP, UK","institution_ids":["https://openalex.org/I2800516725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031059415"],"corresponding_institution_ids":["https://openalex.org/I2800516725"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":1.887,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.87973998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"29","issue":"4","first_page":"402","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":1.0},{"id":"https://openalex.org/keywords/spina-bifida","display_name":"spina bifida","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prenatal-screening","display_name":"prenatal screening","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ventricular-dilation","display_name":"ventriculomegaly","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cerebellar-hypoplasia","display_name":"cerebellar hypoplasia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/3d-ultrasound","display_name":"3D ultrasound","score":0.75},{"id":"https://openalex.org/keywords/level-of-injury","display_name":"injury level","score":0.6899999976158142},{"id":"https://openalex.org/keywords/wheelchair-dependence","display_name":"wheelchair dependence","score":0.6340000033378601},{"id":"https://openalex.org/keywords/abortion","display_name":"abortion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prenatal-counselling","display_name":"prenatal counseling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C2778478650","wikidata":"https://www.wikidata.org/wiki/Q844717","display_name":"Spina bifida","level":2,"score":0.8797951936721802},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.7550768852233887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7049204707145691},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.6640313863754272},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.649122416973114},{"id":"https://openalex.org/C2776212519","wikidata":"https://www.wikidata.org/wiki/Q17146272","display_name":"Ventriculomegaly","level":4,"score":0.619238555431366},{"id":"https://openalex.org/C3018956284","wikidata":"https://www.wikidata.org/wiki/Q2642447","display_name":"Prenatal ultrasound","level":5,"score":0.4902980625629425},{"id":"https://openalex.org/C2777003008","wikidata":"https://www.wikidata.org/wiki/Q548213","display_name":"Neural tube defect","level":4,"score":0.483602911233902},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4390435516834259},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40679454803466797},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3864751160144806},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.38008955121040344},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32978326082229614},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2416830062866211},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.09835991263389587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000757","descriptor_name":"Anencephaly","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000757","descriptor_name":"Anencephaly","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003376","descriptor_name":"Counseling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004677","descriptor_name":"Encephalocele","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004677","descriptor_name":"Encephalocele","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008588","descriptor_name":"Meningocele","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008588","descriptor_name":"Meningocele","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016135","descriptor_name":"Spinal Dysraphism","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D016135","descriptor_name":"Spinal Dysraphism","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D016216","descriptor_name":"Ultrasonography, Prenatal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/pd.2250","doi":"https://doi.org/10.1002/pd.2250","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pd.2250","pdf_url":null,"source":{"id":"https://openalex.org/S171405753","display_name":"Prenatal Diagnosis","issn_l":"0197-3851","issn":["0197-3851","1097-0223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal Diagnosis","raw_type":"journal-article"},{"id":"pmid:19301349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19301349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prenatal diagnosis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W205717150","https://openalex.org/W1877660694","https://openalex.org/W1965202521","https://openalex.org/W1975022326","https://openalex.org/W1977299945","https://openalex.org/W1977817756","https://openalex.org/W1979599416","https://openalex.org/W1982244228","https://openalex.org/W1988909304","https://openalex.org/W1990681806","https://openalex.org/W1997779015","https://openalex.org/W2006783937","https://openalex.org/W2007757072","https://openalex.org/W2014313665","https://openalex.org/W2015487852","https://openalex.org/W2017489043","https://openalex.org/W2018001745","https://openalex.org/W2019581631","https://openalex.org/W2021046839","https://openalex.org/W2030595671","https://openalex.org/W2032882140","https://openalex.org/W2033176881","https://openalex.org/W2036088771","https://openalex.org/W2044665342","https://openalex.org/W2050053559","https://openalex.org/W2057562953","https://openalex.org/W2070162532","https://openalex.org/W2070575905","https://openalex.org/W2081603776","https://openalex.org/W2081800259","https://openalex.org/W2082548973","https://openalex.org/W2091929015","https://openalex.org/W2092081704","https://openalex.org/W2098503450","https://openalex.org/W2100050383","https://openalex.org/W2101620705","https://openalex.org/W2107168086","https://openalex.org/W2107615644","https://openalex.org/W2111522573","https://openalex.org/W2112603336","https://openalex.org/W2114446099","https://openalex.org/W2118846316","https://openalex.org/W2128749005","https://openalex.org/W2128979552","https://openalex.org/W2146315544","https://openalex.org/W2146350496","https://openalex.org/W2150406400","https://openalex.org/W2155641954","https://openalex.org/W2161035003","https://openalex.org/W2169861594","https://openalex.org/W2172258874","https://openalex.org/W2222146826","https://openalex.org/W2395428948","https://openalex.org/W2396070836","https://openalex.org/W2410358208","https://openalex.org/W2416840213","https://openalex.org/W2489630101","https://openalex.org/W2604452052","https://openalex.org/W4247452065","https://openalex.org/W4249094929"],"related_works":["https://openalex.org/W3207597946","https://openalex.org/W193405326","https://openalex.org/W170119783","https://openalex.org/W2131319778","https://openalex.org/W2120197364","https://openalex.org/W4291824702","https://openalex.org/W2026520953","https://openalex.org/W2756042229","https://openalex.org/W1483605136","https://openalex.org/W2406793327"],"abstract_inverted_index":{"This":[0],"review":[1],"article":[2],"discusses":[3],"prenatal":[4,139],"screening":[5,21],"and":[6,51,75,134],"diagnosis":[7],"of":[8,42,47,82,106,112,125,132,138],"neural":[9],"tube":[10],"defects":[11],"(NTD).":[12],"High":[13],"detection":[14],"rates":[15,111],"occur":[16],"in":[17,103,118],"countries":[18],"operating":[19],"ultrasound":[20,26,91],"programmes":[22],"because":[23],"classical":[24],"two-dimensional":[25],"cranial":[27],"signs":[28],"(lemon":[29],"shaped":[30],"head,":[31],"banana":[32],"cerebellum,":[33],"ventriculomegaly)":[34],"are":[35,109],"important":[36],"diagnostic":[37,97],"clues":[38],"to":[39,66],"the":[40,49,67,87,123],"presence":[41],"spina":[43,63,116],"bifida.":[44],"Careful":[45],"evaluation":[46],"both":[48],"spine":[50],"a":[52,71,78,136],"search":[53],"for":[54,62,115],"other":[55],"abnormalities":[56],"is":[57],"warranted.":[58],"Important":[59],"prognostic":[60],"information":[61],"bifida":[64,117],"relates":[65],"lesion":[68],"level,":[69],"with":[70,86],"\"watershed\"":[72],"between":[73],"L3":[74],"L4":[76],"marking":[77],"very":[79],"high":[80,110],"chance":[81],"being":[83],"wheelchair":[84],"bound":[85],"higher":[88],"lesions.":[89],"Three-dimensional":[90],"using":[92],"multiplanar":[93],"views":[94],"can":[95],"achieve":[96],"accuracy":[98],"within":[99],"one":[100],"vertebral":[101],"body":[102],"around":[104],"80%":[105],"patients.":[107],"There":[108],"pregnancy":[113],"termination":[114],"many":[119],"European":[120],"countries,":[121],"but":[122],"use":[124],"new":[126],"imagining":[127],"techniques":[128],"allow":[129],"better":[130],"prediction":[131],"outcome,":[133],"consequently":[135],"refinement":[137],"counselling.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}