{"id":"https://openalex.org/W1971783075","doi":"https://doi.org/10.1016/j.jalz.2011.05.1121","title":"P2\u2010237: Neuropathological and biochemical characterization of the oldestold with and without Alzheimer's disease","display_name":"P2\u2010237: Neuropathological and biochemical characterization of the oldestold with and without Alzheimer's disease","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W1971783075","doi":"https://doi.org/10.1016/j.jalz.2011.05.1121","mag":"1971783075"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.1121","doi":"https://doi.org/10.1016/j.jalz.2011.05.1121","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.1121","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.1121","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.1121","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077900199","display_name":"Tyler A. Kokjohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Kokjohn","raw_affiliation_strings":["Midwestern University, Glendale, Arizona, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwestern University, Glendale, Arizona, United States","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063456886","display_name":"Chera L. Maarouf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chera Maarouf","raw_affiliation_strings":["Banner Sun Health Research Institute Sun City Arizona United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Sun Health Research Institute Sun City Arizona United States","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438902","display_name":"Randy L Woltjer","orcid":"https://orcid.org/0000-0003-0755-9846","observed_orcids":["https://orcid.org/0000-0003-0755-9846"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy Woltjer","raw_affiliation_strings":["Oregon Health and Science University, Portland, Oregon, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, Oregon, United States","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613176","display_name":"Thomas G. Beach","orcid":"https://orcid.org/0000-0003-3296-6128","observed_orcids":["https://orcid.org/0000-0003-3296-6128"]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Beach","raw_affiliation_strings":["Banner Sun Health Research Institute Sun City Arizona United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Sun Health Research Institute Sun City Arizona United States","institution_ids":["https://openalex.org/I4210145600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088826311","display_name":"Alex E. Roher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145600","display_name":"Banner Sun Health Research Institute","ror":"https://ror.org/04gjkkf30","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802412784","https://openalex.org/I4210145600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Roher","raw_affiliation_strings":["Banner Sun Health Research Institute Sun City Arizona United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Banner Sun Health Research Institute Sun City Arizona United States","institution_ids":["https://openalex.org/I4210145600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13187228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4S_Part_11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oldest-old","display_name":"oldest old","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.7892693281173706},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6846384406089783},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5230680108070374},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5143660306930542},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4815140664577484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46380260586738586},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.46374616026878357},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.44539809226989746},{"id":"https://openalex.org/C2780906993","wikidata":"https://www.wikidata.org/wiki/Q5133756","display_name":"Clinical Dementia Rating","level":4,"score":0.434344619512558},{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.42178601026535034},{"id":"https://openalex.org/C2779721402","wikidata":"https://www.wikidata.org/wiki/Q767442","display_name":"Neurofibrillary tangle","level":5,"score":0.41958943009376526},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4192749857902527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40433838963508606},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3729962110519409},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3508763015270233},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3049335479736328},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.23904094099998474}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.1121","doi":"https://doi.org/10.1016/j.jalz.2011.05.1121","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.1121","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.1121","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2011.05.1121","doi":"https://doi.org/10.1016/j.jalz.2011.05.1121","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.1121","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2011.05.1121","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1971783075.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037677220","https://openalex.org/W2332021873","https://openalex.org/W2152718790","https://openalex.org/W2329324611","https://openalex.org/W2766496315","https://openalex.org/W7126284544","https://openalex.org/W2030260517","https://openalex.org/W2769719284","https://openalex.org/W2113573116","https://openalex.org/W2114222094"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"biochemistry":[3],"has":[4],"been":[5],"studied":[6],"extensively,":[7],"but":[8],"the":[9,16,51,63,115,180,198,264,313],"precise":[10],"role(s)":[11],"of":[12,18,30,53,110,117,125,151,284,317,322],"amyloid-beta":[13],"(A\u00df)":[14],"in":[15,50,59,83,173,212,222,234,263,279,288,305,327],"instigation":[17],"dementia":[19],"remains":[20],"obscure.":[21],"It":[22],"is":[23,231],"essential":[24],"to":[25,61,113,129,228,236],"establish":[26],"a":[27,108,123],"complete":[28],"roster":[29],"dementia-associated":[31],"molecules.":[32],"Utilizing":[33],"non-demented":[34],"high":[35],"pathology":[36,259],"control":[37],"(ND-HPC)":[38],"cases":[39],"harboring":[40],"autopsy-confirmed":[41],"A\u00df":[42,72,248],"deposits,":[43,238],"we":[44],"examined":[45,71],"twenty-three":[46],"protein":[47,76],"markers":[48,82,127,269],"present":[49],"brains":[52],"cognitively":[54],"intact":[55],"and":[56,79,87,93,99,107,122,132,140,145,163,219,273,286,298,303,315],"demented":[57],"individuals":[58,84],"order":[60],"assess":[62],"molecular":[64],"profiles":[65],"associated":[66,253],"with":[67,92,254,333],"normal":[68],"cognition.":[69],"We":[70],"profiles,":[73],"amyloid":[74,156,237],"precursor":[75],"(APP),":[77],"tau":[78],"other":[80,126],"disease-related":[81],"(87":[85],"years":[86],"older)":[88],"exhibiting":[89],"AD":[90,101,139,199,213,223,230,280,289,306,328],"neuropathology":[91],"without":[94],"clinical":[95],"dementia.":[96,255],"Eighteen":[97],"ND-HPC":[98,141,265],"6":[100],"subjects":[102],"were":[103,143,177,194,209,224],"investigated":[104],"by":[105],"ELISAs":[106],"battery":[109],"Western":[111],"blots":[112],"determine":[114],"expression":[116],"A\u00df,":[118],"APP,":[119,216],"tau,":[120],"a-synuclein,":[121],"variety":[124],"related":[128],"aging,":[130],"inflammation":[131],"neurodegeneration.":[133],"Mean":[134],"Braak":[135],"stage":[136],"values":[137],"for":[138],"groups":[142],"5.3":[144],"3.9,":[146],"respectively":[147],"although":[148,197,239],"neuropathological":[149],"analyses":[150],"total":[152],"plaque":[153,245],"score,":[154,158],"cerebral":[155],"angiopathy":[157],"white":[159],"matter":[160],"rarefaction":[161],"score":[162,165],"NFT":[164,258],"exhibited":[166],"no":[167],"significant":[168],"differences.":[169],"No":[170],"obvious":[171],"differences":[172],"ApoE":[174,220,287],"allelic":[175],"frequency":[176],"apparent":[178],"between":[179,312],"groups.":[181],"ELISA":[182],"revealed":[183],"that":[184,243],"mean":[185],"A\u00df40":[186],"levels":[187,221,250,300],"extracted":[188],"using":[189],"glass-distilled":[190],"formic":[191],"acid/guanidine":[192],"hydrochloride":[193],"significantly":[195,210,225],"different,":[196],"group":[200],"contained":[201],"2":[202],"outliers.":[203],"A11":[204],"(oligomer),":[205],"IDE,":[206],"PEDF,":[207],"BDNF":[208],"elevated":[211,304,320],"patients":[214],"while":[215],"BACE,":[217],"VEGF,":[218],"decreased":[226,302],"compared":[227],"ND-HPC.":[229],"often":[232],"defined":[233],"relation":[235],"our":[240],"experiments":[241],"reveal":[242],"neither":[244],"density":[246],"nor":[247],"peptide":[249],"are":[251,301],"strongly":[252],"In":[256],"addition,":[257],"was":[260],"less":[261],"abundant":[262],"group.":[266],"Other":[267],"angiogenesis-associated":[268],"such":[270],"as":[271],"PEDF":[272],"VEGF":[274],"exhibit":[275],"inverse":[276],"quantitative":[277],"relationships":[278],"patients.":[281],"Decreased":[282],"quantities":[283],"APP":[285],"suggest":[290,329],"impaired":[291],"synthesis":[292,314],"or":[293],"enhanced":[294],"turnover.":[295],"Interestingly,":[296],"BACE":[297],"IDE":[299],"respectively,":[307],"suggesting":[308],"an":[309],"altered":[310],"equilibrium":[311],"degradation":[316],"A\u00df.":[318],"The":[319],"amounts":[321],"truncated":[323],"proBDNF":[324],"(28":[325],"kDa)":[326],"aberrant":[330],"proteolytic":[331],"processing":[332],"potential":[334],"consequential":[335],"effects":[336],"on":[337],"brain":[338],"homeostasis.":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
