{"id":"https://openalex.org/W1971779178","doi":"https://doi.org/10.1212/wnl.30.11.1233","title":"Interactions of valproic acid with phenytoin","display_name":"Interactions of valproic acid with phenytoin","publication_year":1980,"publication_date":"1980-11-01","ids":{"openalex":"https://openalex.org/W1971779178","doi":"https://doi.org/10.1212/wnl.30.11.1233","mag":"1971779178","pmid":"https://pubmed.ncbi.nlm.nih.gov/6775245"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.30.11.1233","doi":"https://doi.org/10.1212/wnl.30.11.1233","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.30.11.1233","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090879368","display_name":"Joseph Bruni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bruni","raw_affiliation_strings":["Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056500955","display_name":"James M. Gallo","orcid":"https://orcid.org/0000-0003-1553-4817","observed_orcids":["https://orcid.org/0000-0003-1553-4817"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Gallo","raw_affiliation_strings":["Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053146319","display_name":"C. S. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. S. Lee","raw_affiliation_strings":["Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019035760","display_name":"Robert J. Perchalski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Perchalski","raw_affiliation_strings":["Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110902905","display_name":"B. J. Wilder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. J. Wilder","raw_affiliation_strings":["Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Veterans Administration Medical Center and University of Florida College of Medicine (Drs. Bruni and Wilder), University of Florida College of pharmacy (Drs. Gallo and Lee), and the Veterans Administration Research Service, Veterans Administration Medical Center (Mr. Perchalski), Gainesville, FL","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8034,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95786973,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"30","issue":"11","first_page":"1233","last_page":"1233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.09679999947547913,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":1.0},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6970000267028809},{"id":"https://openalex.org/keywords/protein-binding-displacement","display_name":"protein binding displacement","score":0.828000009059906},{"id":"https://openalex.org/keywords/free-fraction","display_name":"free fraction","score":0.5440000295639038},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.7519999742507935},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.6629999876022339},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.872337281703949},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.849703311920166},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.512351393699646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5002014636993408},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.44271910190582275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.392663836479187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.349109411239624},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10326045751571655}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.30.11.1233","doi":"https://doi.org/10.1212/wnl.30.11.1233","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.30.11.1233","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:6775245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6775245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051427702","https://openalex.org/W1999808365","https://openalex.org/W2040170367","https://openalex.org/W2028019428","https://openalex.org/W2031821642","https://openalex.org/W2292289719","https://openalex.org/W2041378367","https://openalex.org/W2029288766","https://openalex.org/W2013453501","https://openalex.org/W1977079818"],"abstract_inverted_index":{"The":[0,95],"interaction":[1],"of":[2,41],"phenytoin":[3,18,44,74,102,113],"and":[4,26,52,66,87,110],"valproic":[5,32,99],"acid":[6,33,100],"was":[7],"studied":[8,13],"in":[9,16,37,49,59,72,81,91,106,115],"four":[10,30,93,108],"adults.":[11],"We":[12],"serial":[14],"changes":[15,71],"total":[17,73],"concentrations,":[19],"protein":[20],"binding,":[21],"urinary":[22],"hydroxyphenylphenylhydantoin":[23],"(HPPH)":[24],"excretion,":[25],"half-life.":[27],"In":[28],"all":[29,92,107],"patients":[31,51,83,109],"caused":[34],"an":[35],"increase":[36],"the":[38,56],"free":[39],"fraction":[40],"phenytoin.":[42],"Total":[43],"plasma":[45,75],"concentrations":[46],"decreased":[47,80],"transiently":[48,65,79],"three":[50,82,116],"remained":[53],"low":[54],"throughout":[55],"study":[57],"period":[58],"one":[60],"patient.":[61],"HPPH":[62],"excretion":[63],"increased":[64,89],"then":[67],"decreased,":[68],"corresponding":[69],"to":[70],"concentrations.":[76],"Biologic":[77],"half-life":[78],"(not":[84],"statistically":[85],"significant)":[86],"subsequently":[88,111],"significantly":[90],"patients.":[94,117],"data":[96],"suggest":[97],"that":[98],"displaced":[101],"from":[103],"protein-binding":[104],"sites":[105],"inhibited":[112],"metabolism":[114]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}