{"id":"https://openalex.org/W1971753613","doi":"https://doi.org/10.1002/hep.21315","title":"Involvement of integrin-linked kinase in carbon tetrachloride\u2013induced hepatic fibrosis in rats","display_name":"Involvement of integrin-linked kinase in carbon tetrachloride\u2013induced hepatic fibrosis in rats","publication_year":2006,"publication_date":"2006-08-30","ids":{"openalex":"https://openalex.org/W1971753613","doi":"https://doi.org/10.1002/hep.21315","mag":"1971753613","pmid":"https://pubmed.ncbi.nlm.nih.gov/16941698"},"language":"en","primary_location":{"id":"doi:10.1002/hep.21315","doi":"https://doi.org/10.1002/hep.21315","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.21315","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1971753613"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tsukuba.repo.nii.ac.jp/record/14257/files/A4428.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100722413","display_name":"Yining Zhang","orcid":"https://orcid.org/0000-0002-8750-795X","observed_orcids":["https://orcid.org/0000-0002-8750-795X"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yining Zhang","raw_affiliation_strings":["Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, and Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Japan","Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","Yining Zhang and Tadashi Ikegami contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, and Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I158929114"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Yining Zhang and Tadashi Ikegami contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077739041","display_name":"Tadashi Ikegami","orcid":"https://orcid.org/0000-0002-9216-3186","observed_orcids":["https://orcid.org/0000-0002-9216-3186"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Ikegami","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Inashiki-gun, Japan","Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","Yining Zhang and Tadashi Ikegami contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Inashiki-gun, Japan","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Yining Zhang and Tadashi Ikegami contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103054778","display_name":"Akira Honda","orcid":"https://orcid.org/0000-0003-0902-8272","observed_orcids":["https://orcid.org/0000-0003-0902-8272"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405256201","display_name":"Ibaraki Prefectural Institute of Public Health","ror":"https://ror.org/03wjngf63","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Honda","raw_affiliation_strings":["Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","Ibaraki Prefectural Institute of Public Health, Mito City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Ibaraki Prefectural Institute of Public Health, Mito City, Japan","institution_ids":["https://openalex.org/I4405256201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034366934","display_name":"Teruo Miyazaki","orcid":"https://orcid.org/0000-0001-9796-3011","observed_orcids":["https://orcid.org/0000-0001-9796-3011"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teruo Miyazaki","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, George Washington University Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, George Washington University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060493687","display_name":"Bernard E. Bouscarel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard Bouscarel","raw_affiliation_strings":["Department of Medicine, George Washington University Medical Center, Washington, DC","Department of Molecular Biology and Biochemistry, George Washington University Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, George Washington University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, George Washington University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026268103","display_name":"Marcos Rojkind","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcos Rojkind","raw_affiliation_strings":["Department of Medicine, George Washington University Medical Center, Washington, DC","Department of Pathology, George Washington University Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, George Washington University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Department of Pathology, George Washington University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112855518","display_name":"Ichinosuke Hyodo","orcid":"https://orcid.org/0000-0001-8210-0731","observed_orcids":["https://orcid.org/0000-0001-8210-0731"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichinosuke Hyodo","raw_affiliation_strings":["Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111860809","display_name":"Yasushi Matsuzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasushi Matsuzaki","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Inashiki-gun, Japan","Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","fax: (81) 29-888-3463"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Inashiki-gun, Japan","institution_ids":["https://openalex.org/I158929114"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"fax: (81) 29-888-3463","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111860809"],"corresponding_institution_ids":["https://openalex.org/I146399215","https://openalex.org/I158929114"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":2.854,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.89616101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"44","issue":"3","first_page":"612","last_page":"622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-linked-kinase","display_name":"integrin-linked kinase","score":1.0},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/stellate-cell-activation","display_name":"stellate cell activation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.7350000143051147},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.875},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9909999966621399},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9810000061988831},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.9429486989974976},{"id":"https://openalex.org/C66417403","wikidata":"https://www.wikidata.org/wiki/Q20970072","display_name":"Integrin-linked kinase","level":5,"score":0.7574270963668823},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.540763795375824},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4658440351486206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45728960633277893},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4540449380874634},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.44679051637649536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44321584701538086},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43800193071365356},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.43139585852622986},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4242924749851227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40584951639175415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3919985890388489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3635023832321167},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.36045190691947937},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3315826952457428},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.31510627269744873},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.31027787923812866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23167738318443298},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21972033381462097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10520803928375244},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.06906339526176453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099200","descriptor_name":"Scaffold Protein ILK","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.21315","doi":"https://doi.org/10.1002/hep.21315","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.21315","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:16941698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16941698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Comparative Study"},{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:00014257","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/record/14257/files/A4428.pdf","pdf_url":"https://tsukuba.repo.nii.ac.jp/record/14257/files/A4428.pdf","source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:3145011081","doi":null,"is_oa":false,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/?action=pages_view_main&active_action=repository_view_main_item_detail&item_id=14257&item_no=1&page_id=13&block_id=83","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:00014257","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/record/14257/files/A4428.pdf","pdf_url":"https://tsukuba.repo.nii.ac.jp/record/14257/files/A4428.pdf","source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G164231255","display_name":"Control of cAMP Mediated Glucagon Response by Bile Acids","funder_award_id":"R01DK056108","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G232773556","display_name":"Role of Acetaldehyde on PDGF-BB-induced HSC Migration and Proliferation.","funder_award_id":"R01AA010541","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1212464357","https://openalex.org/W1598270217","https://openalex.org/W1967680684","https://openalex.org/W1969111880","https://openalex.org/W1972037817","https://openalex.org/W1975981230","https://openalex.org/W1976071667","https://openalex.org/W1982999513","https://openalex.org/W1986779411","https://openalex.org/W1987503773","https://openalex.org/W1990873735","https://openalex.org/W1997064567","https://openalex.org/W2000342376","https://openalex.org/W2007214769","https://openalex.org/W2008130230","https://openalex.org/W2012919091","https://openalex.org/W2016498524","https://openalex.org/W2018103937","https://openalex.org/W2024774077","https://openalex.org/W2035166345","https://openalex.org/W2043310765","https://openalex.org/W2053651590","https://openalex.org/W2056662521","https://openalex.org/W2058473236","https://openalex.org/W2060660978","https://openalex.org/W2066655008","https://openalex.org/W2067427407","https://openalex.org/W2069038608","https://openalex.org/W2076517608","https://openalex.org/W2080325240","https://openalex.org/W2086519275","https://openalex.org/W2095252793","https://openalex.org/W2095290717","https://openalex.org/W2103049122","https://openalex.org/W2110731221","https://openalex.org/W2114248978","https://openalex.org/W2126270623","https://openalex.org/W2138825607","https://openalex.org/W2140925895","https://openalex.org/W2148184356","https://openalex.org/W2148656182","https://openalex.org/W2154342180","https://openalex.org/W2161803404","https://openalex.org/W2164078851","https://openalex.org/W2164864100","https://openalex.org/W2165022280","https://openalex.org/W2243440920","https://openalex.org/W2314254441","https://openalex.org/W2430310908","https://openalex.org/W2913716258","https://openalex.org/W6698983579"],"related_works":["https://openalex.org/W2081716665","https://openalex.org/W1980394389","https://openalex.org/W2102081625","https://openalex.org/W944912497","https://openalex.org/W6925078980","https://openalex.org/W4313436470","https://openalex.org/W2973417843","https://openalex.org/W3029610374","https://openalex.org/W2987326932","https://openalex.org/W3214455524"],"abstract_inverted_index":{"Integrin-linked":[0],"kinase":[1],"(ILK)":[2],"is":[3,22,50,156],"a":[4,61,180,206,215],"multidomain":[5],"focal":[6],"adhesion":[7],"protein":[8],"implicated":[9],"in":[10,24,31,52,63,91,95,121,148,158,179,183,209],"signal":[11],"transduction":[12],"between":[13],"integrins":[14],"and":[15,26,58,83,87,112,116,167,169,196,212],"growth":[16],"factor":[17],"receptors.":[18],"Although":[19],"its":[20,29,139],"expression":[21,82,118,140,175],"upregulated":[23],"pulmonary":[25],"renal":[27],"fibrosis,":[28],"role":[30,62,208],"the":[32,64,144,159],"development":[33,65],"of":[34,54,66,71,85,110,161,173,193],"hepatic":[35,55,67,92,100,125],"fibrosis":[36],"remains":[37],"to":[38,46],"be":[39,214],"determined.":[40],"Therefore,":[41],"we":[42],"considered":[43],"it":[44],"important":[45],"investigate":[47],"whether":[48],"ILK":[49,86,111,155,174,204],"involved":[51,157],"activation":[53,211],"stellate":[56,93,101,126],"cells":[57,94,102,127,145],"thus":[59],"plays":[60,205],"fibrosis.":[68],"Immunohistochemical":[69],"analysis":[70],"liver":[72,133],"sections":[73],"obtained":[74],"from":[75,104,130],"rats":[76],"with":[77],"CCl4-induced":[78],"cirrhosis":[79],"revealed":[80],"increased":[81,142],"colocalization":[84],"alpha-smooth":[88,113],"muscle":[89,114],"actin":[90],"perisinusoidal":[96],"areas.":[97],"In":[98,123,202],"addition,":[99],"isolated":[103,129],"fibrotic":[105],"livers":[106],"expressed":[107],"high":[108],"levels":[109],"actin,":[115],"their":[117,184],"was":[119,141],"sustained":[120],"culture.":[122,149],"contrast,":[124],"(HSCs)":[128],"normal":[131],"rat":[132],"did":[134],"not":[135],"express":[136],"ILK,":[137],"but":[138],"when":[143],"were":[146,188],"activated":[147],"Our":[150],"studies":[151],"also":[152],"showed":[153],"that":[154,170],"phosphorylation":[160],"ERK":[162],"1/2,":[163],"p38":[164],"MAPK,":[165],"JNK,":[166],"PKB":[168],"selective":[171],"inhibition":[172,192],"by":[176,190],"siRNA":[177],"results":[178],"significant":[181,191],"decrease":[182],"phosphorylation.":[185],"These":[186],"changes":[187],"accompanied":[189],"cell":[194,200],"spreading":[195],"migration":[197],"without":[198],"affecting":[199],"proliferation.":[201],"conclusion,":[203],"key":[207],"HSC":[210],"could":[213],"possible":[216],"target":[217],"for":[218],"antifibrogenic":[219],"therapy.":[220]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
