{"id":"https://openalex.org/W1971667095","doi":"https://doi.org/10.1002/ijc.2910620415","title":"Patterns of splice variant CD44 expression by normal human urothelium in situ and in vitro and by bladder\u2010carcinoma cell lines","display_name":"Patterns of splice variant CD44 expression by normal human urothelium in situ and in vitro and by bladder\u2010carcinoma cell lines","publication_year":1995,"publication_date":"1995-08-09","ids":{"openalex":"https://openalex.org/W1971667095","doi":"https://doi.org/10.1002/ijc.2910620415","mag":"1971667095","pmid":"https://pubmed.ncbi.nlm.nih.gov/7543458"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910620415","doi":"https://doi.org/10.1002/ijc.2910620415","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910620415","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025375470","display_name":"Jennifer Southgate","orcid":"https://orcid.org/0000-0002-0135-480X","observed_orcids":["https://orcid.org/0000-0002-0135-480X"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jennifer Southgate","raw_affiliation_strings":["Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds, UK","Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK. Fax: 44(0)1132429886"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK. Fax: 44(0)1132429886","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110867739","display_name":"L K Trejdosiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ludwik K. Trejdosiewicz","raw_affiliation_strings":["Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004681741","display_name":"Barbara A. Smith","orcid":"https://orcid.org/0009-0002-2413-6466","observed_orcids":["https://orcid.org/0009-0002-2413-6466"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barbara Smith","raw_affiliation_strings":["Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086212361","display_name":"Peter John Selby","orcid":"https://orcid.org/0000-0002-3782-069X","observed_orcids":["https://orcid.org/0000-0002-3782-069X","https://orcid.org/0000-0001-5401-2996","https://orcid.org/0000-0001-9465-9268"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter J. Selby","raw_affiliation_strings":["Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund Cancer Medicine Research Unit, St. James's University Hospital, Leeds LS9 7TF, UK","institution_ids":["https://openalex.org/I2801331674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025375470"],"corresponding_institution_ids":["https://openalex.org/I2801331674"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.3499,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78886582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"62","issue":"4","first_page":"449","last_page":"456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9729999899864197},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.902999997138977},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8460000157356262},{"id":"https://openalex.org/keywords/urothelium","display_name":"urothelium","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.652999997138977},{"id":"https://openalex.org/keywords/cd44v3","display_name":"CD44v3","score":0.6069999933242798},{"id":"https://openalex.org/keywords/cd44v5","display_name":"CD44v5","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd44v6","display_name":"CD44v6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mrna-transcripts","display_name":"mRNA transcripts","score":0.44999998807907104},{"id":"https://openalex.org/keywords/bladder-cancer-cell-lines","display_name":"bladder cancer cell lines","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7747930884361267},{"id":"https://openalex.org/C2777540882","wikidata":"https://www.wikidata.org/wiki/Q11878994","display_name":"Urothelium","level":3,"score":0.6875494718551636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6599875092506409},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.547762930393219},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5393073558807373},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5349553823471069},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.513272762298584},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5093544721603394},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.47289741039276123},{"id":"https://openalex.org/C2910041100","wikidata":"https://www.wikidata.org/wiki/Q11878994","display_name":"Urothelial Cell","level":4,"score":0.468969464302063},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4579211473464966},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3928314745426178},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3825950622558594},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3209589123725891},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16446205973625183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1465051770210266},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11740797758102417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10612872242927551},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.08862292766571045}],"mesh":[{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007682","descriptor_name":"Kidney Pelvis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014513","descriptor_name":"Ureter","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016201","descriptor_name":"Receptors, Lymphocyte Homing","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910620415","doi":"https://doi.org/10.1002/ijc.2910620415","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910620415","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:7543458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7543458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W156574667","https://openalex.org/W301210341","https://openalex.org/W1211643602","https://openalex.org/W1499793500","https://openalex.org/W1584652055","https://openalex.org/W1870544273","https://openalex.org/W1969245473","https://openalex.org/W1984831820","https://openalex.org/W1985585224","https://openalex.org/W1992072758","https://openalex.org/W2006585422","https://openalex.org/W2018755526","https://openalex.org/W2031742143","https://openalex.org/W2048799695","https://openalex.org/W2075747617","https://openalex.org/W2090831096","https://openalex.org/W2094657840","https://openalex.org/W2139619397","https://openalex.org/W2150468943","https://openalex.org/W2152331429","https://openalex.org/W2155230404","https://openalex.org/W2419337843","https://openalex.org/W2419499514"],"related_works":["https://openalex.org/W4300553811","https://openalex.org/W2430733285","https://openalex.org/W2765777176","https://openalex.org/W2470430755","https://openalex.org/W2048114877","https://openalex.org/W2339238563","https://openalex.org/W2973553336","https://openalex.org/W2373682614","https://openalex.org/W29820694","https://openalex.org/W2097415039"],"abstract_inverted_index":{"CD44":[0,32,80,93,114,133,155,164],"core":[1,31,94],"and":[2,18,21,34,41,50,64,87,96,102,127,150],"splice":[3,35,97],"variant":[4,148],"exon":[5,36],"expression":[6],"was":[7,57],"investigated":[8],"in":[9,19,27,47,170],"the":[10,15,48,61,105,171],"stratified":[11],"transitional":[12],"epithelium":[13],"of":[14,162,173],"urinary":[16],"tract":[17],"normal":[20,74,139],"malignant":[22],"bladder":[23,175],"epithelial":[24],"cell":[25,54,66,70,108,119,142],"lines":[26,71,120,143],"vitro.":[28],"Antibodies":[29],"against":[30,92],"epitopes":[33,95],"variants":[37,98],"v3,":[38,99],"v4/5,":[39,100],"v5":[40,101],"v6":[42],"showed":[43,128],"an":[44],"intense":[45],"reaction":[46],"basal":[49],"lower":[51],"intermediate":[52,63],"urothelial":[53],"layers,":[55],"which":[56],"consistently":[58],"lost":[59],"from":[60,73],"upper":[62],"superficial":[65],"layers.":[67],"Seven":[68],"independent":[69],"established":[72],"human":[75],"urothelium":[76],"expressed":[77],"complex":[78,132],"multiple-spliced":[79,154],"mRNA":[81,134],"transcripts":[82],"when":[83],"tested":[84],"by":[85],"RT-PCR":[86],"were":[88,111],"positive":[89,112],"with":[90,138,147],"antibodies":[91,149],"v6.":[103],"Of":[104],"13":[106],"bladder-carcinoma":[107],"lines,":[109],"all":[110],"for":[113],"core.":[115],"The":[116],"more":[117],"differentiated":[118],"had":[121],"retained":[122],"some":[123],"splice-variant":[124],"antibody":[125],"reactivity":[126],"multiple":[129],"but":[130],"less":[131],"transcript":[135],"patterns,":[136],"compared":[137],"cells.":[140],"Anaplastic":[141],"did":[144,151],"not":[145,152],"react":[146],"contain":[153],"transcripts.":[156],"These":[157],"data":[158],"suggest":[159],"that":[160],"loss":[161],"alternatively-spliced":[163],"may":[165],"reflect":[166],"a":[167],"selection":[168],"pressure":[169],"evolution":[172],"anaplastic":[174],"cancers.":[176]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}