{"id":"https://openalex.org/W1971627602","doi":"https://doi.org/10.1002/jcp.1041290218","title":"Regulation of gonadotropin receptors, gonadotropin responsiveness, and cell multiplication by somatomedin\u2010C and insulin in cultured pig Leydig cells","display_name":"Regulation of gonadotropin receptors, gonadotropin responsiveness, and cell multiplication by somatomedin\u2010C and insulin in cultured pig Leydig cells","publication_year":1986,"publication_date":"1986-11-01","ids":{"openalex":"https://openalex.org/W1971627602","doi":"https://doi.org/10.1002/jcp.1041290218","mag":"1971627602","pmid":"https://pubmed.ncbi.nlm.nih.gov/3533962"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041290218","doi":"https://doi.org/10.1002/jcp.1041290218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041290218","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M. Bernier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119578","display_name":"H\u00f4pital Debrousse","ror":"https://ror.org/02cc58y38","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210119578"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Bernier","raw_affiliation_strings":["INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France","M. Bernier was supported by a CRSQ-INSERM exchange scientist program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119578"]},{"raw_affiliation_string":"M. Bernier was supported by a CRSQ-INSERM exchange scientist program","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Chatelain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119578","display_name":"H\u00f4pital Debrousse","ror":"https://ror.org/02cc58y38","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210119578"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Chatelain","raw_affiliation_strings":["INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112824383","display_name":"Jennie P. Mather","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119578","display_name":"H\u00f4pital Debrousse","ror":"https://ror.org/02cc58y38","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210119578"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. P. Mather","raw_affiliation_strings":["INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France","J.P. Mather was supported by a NIH-INSERM exchange scientist program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119578"]},{"raw_affiliation_string":"J.P. Mather was supported by a NIH-INSERM exchange scientist program","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109965510","display_name":"J.M. Saez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119578","display_name":"H\u00f4pital Debrousse","ror":"https://ror.org/02cc58y38","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210119578"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J. M. Saez","raw_affiliation_strings":["INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Ho\u030cpital Debrousse, 69322 Lyon Cedex 05, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109965510"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119578"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":9.2439,"has_fulltext":false,"cited_by_count":137,"citation_normalized_percentile":{"value":0.98634985,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"129","issue":"2","first_page":"257","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.13850000500679016,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hcg-receptor","display_name":"hCG receptor","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gonadotropin-response","display_name":"gonadotropin response","score":0.9160000085830688},{"id":"https://openalex.org/keywords/testosterone-production","display_name":"testosterone production","score":0.7870000004768372},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.7085849046707153},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.681596577167511},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6598905324935913},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6199369430541992},{"id":"https://openalex.org/C80862487","wikidata":"https://www.wikidata.org/wiki/Q415679","display_name":"Somatomedin","level":4,"score":0.6035788655281067},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.5453308820724487},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.465073823928833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4315107464790344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.390937864780426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37251347303390503},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.15857452154159546},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14747095108032227},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.1214343011379242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12113255262374878}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011974","descriptor_name":"Receptors, LH","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1041290218","doi":"https://doi.org/10.1002/jcp.1041290218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041290218","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:3533962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3533962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323910","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W53573570","https://openalex.org/W267051729","https://openalex.org/W1152870587","https://openalex.org/W1498071142","https://openalex.org/W1518913349","https://openalex.org/W1560521346","https://openalex.org/W1970638520","https://openalex.org/W1972319572","https://openalex.org/W1974301567","https://openalex.org/W1976018611","https://openalex.org/W1979334671","https://openalex.org/W1982445799","https://openalex.org/W1982679023","https://openalex.org/W2004208175","https://openalex.org/W2005307430","https://openalex.org/W2021670999","https://openalex.org/W2022476396","https://openalex.org/W2024278732","https://openalex.org/W2031486584","https://openalex.org/W2032409176","https://openalex.org/W2032670749","https://openalex.org/W2032737002","https://openalex.org/W2033458917","https://openalex.org/W2035498749","https://openalex.org/W2035575787","https://openalex.org/W2035750608","https://openalex.org/W2040568776","https://openalex.org/W2055840539","https://openalex.org/W2061107904","https://openalex.org/W2061782885","https://openalex.org/W2063088976","https://openalex.org/W2065460036","https://openalex.org/W2065823308","https://openalex.org/W2069579388","https://openalex.org/W2071872101","https://openalex.org/W2074269777","https://openalex.org/W2075012811","https://openalex.org/W2082182989","https://openalex.org/W2085810378","https://openalex.org/W2089846596","https://openalex.org/W2089852734","https://openalex.org/W2092595976","https://openalex.org/W2104120415","https://openalex.org/W2104388565","https://openalex.org/W2117659654","https://openalex.org/W2119808628","https://openalex.org/W2121497355","https://openalex.org/W2137467924","https://openalex.org/W2145481755","https://openalex.org/W2157633786","https://openalex.org/W2166561608","https://openalex.org/W2174542542","https://openalex.org/W2337617776","https://openalex.org/W4210625962","https://openalex.org/W4248449548","https://openalex.org/W4298306388"],"related_works":["https://openalex.org/W2011933006","https://openalex.org/W1558396275","https://openalex.org/W1968267790","https://openalex.org/W2068576382","https://openalex.org/W2012762625","https://openalex.org/W2023266017","https://openalex.org/W2020204716","https://openalex.org/W2065016056","https://openalex.org/W2027128457","https://openalex.org/W2031658422"],"abstract_inverted_index":{"We":[0],"have":[1],"investigated":[2],"the":[3,67,89,93,108,162,174,208,256],"effects":[4,258],"of":[5,110,120,129,164,171,176,188,211,259],"insulin":[6,47,101,156,177,212,229,260],"and":[7,27,30,46,56,85,102,114,133,138,142,155,205,228,247],"somatomedin-C/insulinlike":[8],"growth":[9],"factor":[10],"I(Sm-C)":[11],"in":[12,17,38,66,80],"purified":[13],"porcine":[14],"Leydig":[15,35,236],"cells":[16,36],"vitro":[18],"on":[19,148,213],"gonadotrophins":[20],"(hCG)":[21],"receptor":[22,83,245],"number,":[23],"hCG":[24,54,57,82,86,112,241,244],"responsiveness":[25,239],"(cAMP":[26],"testosterone":[28,94,159],"production),":[29],"thymidine":[31],"incorporation":[32,202],"into":[33,203],"DNA.":[34],"cultured":[37,62],"a":[39,74],"serum-free":[40],"medium":[41,69],"containing":[42],"transferrin,":[43],"vitamin":[44],"E,":[45],"(5":[48,181],"micrograms/ml)":[49,182],"maintained":[50],"fairly":[51],"constant":[52],"both":[53,81,111,121,226],"receptors":[55,113,234],"responsiveness.":[58,87],"When":[59],"they":[60],"were":[61],"for":[63,136],"3":[64],"days":[65],"same":[68],"without":[70],"insulin,":[71,139],"there":[72],"was":[73,98,123,166,183,216],"dramatic":[75],"decline":[76,109],"(more":[77],"than":[78,169,186],"80%)":[79],"number":[84,246],"However":[88],"cAMP":[90,116,252],"but":[91,161],"not":[92],"response":[95],"to":[96,240],"forskolin":[97],"normal.":[99],"Both":[100],"Sm-C":[103,143,154,165,189,199,227,265],"at":[104,178,190,195,219],"nanomolar":[105,152,196],"concentrations":[106,180,197],"prevent":[107],"hCG-induced":[115,158],"production.":[117],"This":[118],"effect":[119,147,163,175,210],"peptides":[122],"dose":[124],"dependent":[125],"with":[126],"an":[127],"ED50":[128],"about":[130],"1":[131],"ng/ml":[132,135],"5":[134],"SM-C":[137],"respectively.":[140],"Insulin":[141],"had":[144],"no":[145],"additive":[146],"these":[149,214],"parameters.":[150],"At":[151],"concentrations,":[153],"enhanced":[157],"production":[160],"significantly":[167,184],"higher":[168,179,185],"that":[170,187,225],"insulin.":[172],"However,":[173],"50":[191],"ng/ml.":[192],"In":[193,254],"contrast,":[194,255],"only":[198,218,263],"stimulated":[200],"[3H]-thymidine":[201],"DNA":[204],"cell":[206,237],"multiplication,":[207],"stimulatory":[209],"parameters,":[215],"seen":[217],"micromolar":[220],"concentrations.":[221],"These":[222],"results":[223],"indicate":[224],"acting":[230],"through":[231,264],"their":[232],"own":[233],"increase":[235],"steroidogenic":[238],"by":[242],"increasing":[243],"improving":[248],"some":[249],"step":[250],"beyond":[251],"formation.":[253],"mitogenic":[257],"are":[261],"mediated":[262],"receptors.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
