{"id":"https://openalex.org/W1971602200","doi":"https://doi.org/10.1002/stem.1326","title":"Evidence for a Crucial Role of Paneth Cells in Mediating the Intestinal Response to Injury","display_name":"Evidence for a Crucial Role of Paneth Cells in Mediating the Intestinal Response to Injury","publication_year":2013,"publication_date":"2013-01-18","ids":{"openalex":"https://openalex.org/W1971602200","doi":"https://doi.org/10.1002/stem.1326","mag":"1971602200","pmid":"https://pubmed.ncbi.nlm.nih.gov/23335179","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3744757"},"language":"en","primary_location":{"id":"doi:10.1002/stem.1326","doi":"https://doi.org/10.1002/stem.1326","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.1326","pdf_url":"https://academic.oup.com/stmcls/article-pdf/31/4/776/41980296/stmcls_31_4_776.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/stmcls/article-pdf/31/4/776/41980296/stmcls_31_4_776.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046528312","display_name":"Lee Parry","orcid":"https://orcid.org/0000-0002-4467-9196","observed_orcids":["https://orcid.org/0000-0002-4467-9196"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lee Parry","raw_affiliation_strings":["School of Bioscience Biosciences, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience Biosciences, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035431425","display_name":"Madeleine A. Young","orcid":"https://orcid.org/0000-0002-1487-0694","observed_orcids":["https://orcid.org/0000-0002-1487-0694"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Madeleine Young","raw_affiliation_strings":["School of Bioscience Biosciences, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience Biosciences, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071271428","display_name":"Fatima El Marjou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fatima El Marjou","raw_affiliation_strings":["Institut Curie, 26 rue d'Ulm, Paris, France","Institut Curie, 26 Rue d'Ulm, Paris, France#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Curie, 26 rue d'Ulm, Paris, France","institution_ids":["https://openalex.org/I80043"]},{"raw_affiliation_string":"Institut Curie, 26 Rue d'Ulm, Paris, France#TAB#","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001013132","display_name":"Alan Richard Clarke","orcid":"https://orcid.org/0000-0002-4281-426X","observed_orcids":["https://orcid.org/0000-0002-4281-426X"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alan R. Clarke","raw_affiliation_strings":["School of Bioscience Biosciences, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience Biosciences, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001013132"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.2322,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86962165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"4","first_page":"776","last_page":"785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.33329999446868896,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.33329999446868896,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.19189999997615814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.12620000541210175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paneth-cells","display_name":"Paneth cells","score":1.0},{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lgr5","display_name":"Lgr5","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/intestinal-regeneration","display_name":"intestinal regeneration","score":0.921999990940094},{"id":"https://openalex.org/keywords/intestinal-injury","display_name":"intestinal injury","score":0.6570000052452087},{"id":"https://openalex.org/keywords/quiescent-stem-cells","display_name":"quiescent stem cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.7160000205039978},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.6690000295639038},{"id":"https://openalex.org/keywords/intestinal-epithelial-integrity","display_name":"intestinal epithelial integrity","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2776145723","wikidata":"https://www.wikidata.org/wiki/Q2004084","display_name":"Paneth cell","level":3,"score":0.9544036388397217},{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.9465276002883911},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.9151395559310913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9024051427841187},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6807302236557007},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6576766967773438},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4670160412788391},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.46214187145233154},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.43219444155693054},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4122897982597351},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36723417043685913},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.27331292629241943},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.260169118642807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23343917727470398},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22742876410484314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13758200407028198},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11373928189277649},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019879","descriptor_name":"Paneth Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019879","descriptor_name":"Paneth Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/stem.1326","doi":"https://doi.org/10.1002/stem.1326","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.1326","pdf_url":"https://academic.oup.com/stmcls/article-pdf/31/4/776/41980296/stmcls_31_4_776.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2736803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3744757","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23335179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23335179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3744757","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3744757/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:45883","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/45883/1/OA-09.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/45883/1/OA-09.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.778.3300","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.778.3300","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5c/21/stem0031-0776.PMC3744757.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1002/stem.1326","doi":"https://doi.org/10.1002/stem.1326","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.1326","pdf_url":"https://academic.oup.com/stmcls/article-pdf/31/4/776/41980296/stmcls_31_4_776.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5620567772","display_name":null,"funder_award_id":"15937","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971602200.pdf","grobid_xml":"https://content.openalex.org/works/W1971602200.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1768274470","https://openalex.org/W1965157206","https://openalex.org/W1967071065","https://openalex.org/W1982603620","https://openalex.org/W1994216131","https://openalex.org/W2003299661","https://openalex.org/W2011623297","https://openalex.org/W2011910303","https://openalex.org/W2014209146","https://openalex.org/W2017218715","https://openalex.org/W2017632960","https://openalex.org/W2017971377","https://openalex.org/W2023649138","https://openalex.org/W2037963573","https://openalex.org/W2043880988","https://openalex.org/W2065220128","https://openalex.org/W2065878510","https://openalex.org/W2080457256","https://openalex.org/W2103597610","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2125311914","https://openalex.org/W2148459495","https://openalex.org/W2157010562","https://openalex.org/W2159155233","https://openalex.org/W2165087323","https://openalex.org/W2165178639","https://openalex.org/W2168901267","https://openalex.org/W2172258358","https://openalex.org/W2312862539","https://openalex.org/W4247382314"],"related_works":["https://openalex.org/W7095856793","https://openalex.org/W4205197122","https://openalex.org/W7160923901","https://openalex.org/W2104081204","https://openalex.org/W1966892435","https://openalex.org/W2157010562","https://openalex.org/W4405611678","https://openalex.org/W4398165658","https://openalex.org/W2037963573","https://openalex.org/W3034229995"],"abstract_inverted_index":{"The":[0],"identification":[1],"of":[2,16,82,92,136,140,148,172,191,203],"the":[3,71,80,83,90,108,113,134,138,144,149,155,158,173,183,189,194,211,219],"intestinal":[4,58,114,204],"stem":[5],"cell":[6],"(ISC)":[7],"markers":[8,31],"Lgr5":[9,84],"and":[10,61,128,170],"Bmi-1":[11],"has":[12,75],"furthered":[13],"our":[14],"understanding":[15],"how":[17,52],"they":[18],"accomplish":[19],"homeostasis":[20,60],"in":[21,119,143,157,160,188,200,220,224],"this":[22],"rapidly":[23],"self-renewing":[24],"tissue.":[25],"Recent":[26],"work":[27],"indicates":[28,209],"that":[29,79,210],"these":[30,53,117],"identify":[32],"a":[33,42,167,179,215],"cycling":[34],"Lgr5(+)":[35],"ISC":[36,85,181,222],"which":[37,161],"can":[38],"be":[39],"replaced":[40],"by":[41],"quiescent":[43,185],"Bmi-1(+)":[44],"ISC.":[45],"Currently,":[46],"there":[47],"is":[48,86],"little":[49],"data":[50,208],"on":[51],"cells":[54,69,127,163,193,213],"interact":[55],"to":[56,89,106,122,132],"control":[57],"crypt":[59],"regeneration.":[62],"This":[63,207],"interaction":[64],"likely":[65],"involves":[66],"other":[67],"differentiated":[68],"within":[70,112,125,218],"niche":[72,223],"as":[73],"it":[74],"previously":[76],"been":[77],"demonstrated":[78],"\"stemness\"":[81],"closely":[87],"tied":[88],"presence":[91,145],"their":[93,120],"neighboring":[94],"Paneth":[95,126,150,162,192,212],"cells.":[96,151],"To":[97],"investigate":[98],"this,":[99],"we":[100],"used":[101],"two":[102],"conditional":[103],"mouse":[104],"models":[105],"delete":[107],"transcription":[109],"factor":[110],"\u03b2-catenin":[111],"crypt.":[115],"Critically":[116],"differ":[118],"ability":[121,196],"drive":[123],"recombination":[124],"therefore":[129],"allow":[130],"us":[131],"compare":[133],"effect":[135],"deleting":[137],"majority":[139],"active":[141],"ISCs":[142],"or":[146,182],"absence":[147,190],"After":[152],"gene":[153],"deletion,":[154],"intestines":[156],"model":[159],"were":[164],"retained":[165],"showed":[166],"rapid":[168],"recovery":[169,195,226],"repopulation":[171],"crypt-villus":[174],"axis":[175],"presumably":[176],"from":[177],"either":[178],"spared":[180],"hypothetical":[184],"ISCs.":[186],"However,":[187],"was":[197],"compromised":[198],"resulting":[199],"complete":[201],"loss":[202],"epithelial":[205],"integrity.":[206],"play":[214],"crucial":[216],"role":[217],"vivo":[221],"aiding":[225],"following":[227],"substantial":[228],"insult.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}