{"id":"https://openalex.org/W1971508990","doi":"https://doi.org/10.1016/s0006-8993(98)00449-1","title":"Neurochemical alterations in the cerebellum of a murine model of Niemann\u2013Pick type C disease","display_name":"Neurochemical alterations in the cerebellum of a murine model of Niemann\u2013Pick type C disease","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W1971508990","doi":"https://doi.org/10.1016/s0006-8993(98)00449-1","mag":"1971508990","pmid":"https://pubmed.ncbi.nlm.nih.gov/9675302"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-8993(98)00449-1","doi":"https://doi.org/10.1016/s0006-8993(98)00449-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(98)00449-1","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088336881","display_name":"Gal Yadid","orcid":"https://orcid.org/0000-0002-4379-8505","observed_orcids":["https://orcid.org/0000-0002-4379-8505"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Gal Yadid","raw_affiliation_strings":["Department of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel. yadidg@brosh.cc.biu.ac.il","Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel. yadidg@brosh.cc.biu.ac.il","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel#TAB#","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023869738","display_name":"I Sotnik-Barkai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Iris Sotnik-Barkai","raw_affiliation_strings":["Department of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel","Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Bar Ilan University, Ramat Gan, 52900, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel#TAB#","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012728062","display_name":"Carlo Tornatore","orcid":"https://orcid.org/0000-0002-2906-3967","observed_orcids":["https://orcid.org/0000-0002-2906-3967"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo Tornatore","raw_affiliation_strings":["Laboratory of Molecular Medicine, NINDS, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine, NINDS, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003228640","display_name":"Belinda Baker-Cairns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Belinda Baker-Cairns","raw_affiliation_strings":["Laboratory of Molecular Medicine, NINDS, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine, NINDS, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082508889","display_name":"Judith Dale Harvey-White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Harvey-White","raw_affiliation_strings":["Laboratory of Monoaminergic Mechanism, NINDS, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Monoaminergic Mechanism, NINDS, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022374182","display_name":"Peter G. Pentchev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G. Pentchev","raw_affiliation_strings":["Laboratories of Developmental and Metabolic Neurology, NINDS, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Developmental and Metabolic Neurology, NINDS, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001617024","display_name":"Ehud Goldin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ehud Goldin","raw_affiliation_strings":["Laboratories of Developmental and Metabolic Neurology, NINDS, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories of Developmental and Metabolic Neurology, NINDS, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088336881"],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.4084,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.62832198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"799","issue":"2","first_page":"250","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niemann-pick-disease-type-c","display_name":"Niemann-Pick disease type C","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8539999723434448},{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/neurotransmitter-alterations","display_name":"neurotransmitter alterations","score":0.6629999876022339},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vermis","display_name":"vermis","score":0.5550000071525574},{"id":"https://openalex.org/keywords/ataxia","display_name":"ataxia","score":0.6539999842643738},{"id":"https://openalex.org/keywords/neurochemistry","display_name":"neurochemistry","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.7526752948760986},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.6262478232383728},{"id":"https://openalex.org/C2778472085","wikidata":"https://www.wikidata.org/wiki/Q1570272","display_name":"Purkinje cell","level":3,"score":0.5508551001548767},{"id":"https://openalex.org/C2780635549","wikidata":"https://www.wikidata.org/wiki/Q2067267","display_name":"Niemann\u2013Pick disease, type C","level":3,"score":0.499281644821167},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.4927404224872589},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4773590564727783},{"id":"https://openalex.org/C2908670167","wikidata":"https://www.wikidata.org/wiki/Q827017","display_name":"Gait Ataxia","level":3,"score":0.4709887206554413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47038522362709045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45597752928733826},{"id":"https://openalex.org/C2992333117","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellar cortex","level":3,"score":0.4487702250480652},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4155886769294739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39528098702430725},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36966124176979065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30518344044685364},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009542","descriptor_name":"Niemann-Pick Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009542","descriptor_name":"Niemann-Pick Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015306","descriptor_name":"Biogenic Monoamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-8993(98)00449-1","doi":"https://doi.org/10.1016/s0006-8993(98)00449-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(98)00449-1","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:9675302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1515444383","https://openalex.org/W1517698792","https://openalex.org/W1525120405","https://openalex.org/W1550289802","https://openalex.org/W1578752381","https://openalex.org/W1609953571","https://openalex.org/W1967647423","https://openalex.org/W1980012680","https://openalex.org/W1981615019","https://openalex.org/W1984070402","https://openalex.org/W1984130880","https://openalex.org/W1987351877","https://openalex.org/W1987488913","https://openalex.org/W2002151621","https://openalex.org/W2002363184","https://openalex.org/W2005405942","https://openalex.org/W2005706099","https://openalex.org/W2026225868","https://openalex.org/W2045941692","https://openalex.org/W2052829355","https://openalex.org/W2053544520","https://openalex.org/W2057041650","https://openalex.org/W2061450786","https://openalex.org/W2063251377","https://openalex.org/W2074683128","https://openalex.org/W2075642203","https://openalex.org/W2076481913","https://openalex.org/W2080524944","https://openalex.org/W2081415721","https://openalex.org/W2108660588","https://openalex.org/W2134893181","https://openalex.org/W2165509591","https://openalex.org/W2168016965","https://openalex.org/W2269462376"],"related_works":["https://openalex.org/W1985015940","https://openalex.org/W2371887806","https://openalex.org/W2069785913","https://openalex.org/W2336942037","https://openalex.org/W2084767050","https://openalex.org/W2005740166","https://openalex.org/W7057136164","https://openalex.org/W2041818629","https://openalex.org/W2025962562","https://openalex.org/W6983509039"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
