{"id":"https://openalex.org/W1971474571","doi":"https://doi.org/10.1523/jneurosci.1537-11.2011","title":"Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway","display_name":"Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway","publication_year":2011,"publication_date":"2011-06-22","ids":{"openalex":"https://openalex.org/W1971474571","doi":"https://doi.org/10.1523/jneurosci.1537-11.2011","mag":"1971474571","pmid":"https://pubmed.ncbi.nlm.nih.gov/21697358","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6623479"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1537-11.2011","doi":"https://doi.org/10.1523/jneurosci.1537-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1537-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/25/9075.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jneurosci.org/content/jneuro/31/25/9075.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056830056","display_name":"Francisco J. Monje","orcid":"https://orcid.org/0000-0002-6496-0030","observed_orcids":["https://orcid.org/0000-0002-6496-0030"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. J. Monje","raw_affiliation_strings":["Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089981309","display_name":"Maureen Cabatic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Cabatic","raw_affiliation_strings":["Departments of Neurophysiology and Neuropharmacology and","Neurophysiology and Neuropharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurophysiology and Neuropharmacology and","institution_ids":[]},{"raw_affiliation_string":"Neurophysiology and Neuropharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089234424","display_name":"Isabella Divisch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Divisch","raw_affiliation_strings":["Departments of Neurophysiology and Neuropharmacology and","Neurophysiology and Neuropharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurophysiology and Neuropharmacology and","institution_ids":[]},{"raw_affiliation_string":"Neurophysiology and Neuropharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"E.-J. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"E.-J. Kim","raw_affiliation_strings":["Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria","Departments of Neurophysiology and Neuropharmacology and","Neurophysiology and Neuropharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Departments of Neurophysiology and Neuropharmacology and","institution_ids":[]},{"raw_affiliation_string":"Neurophysiology and Neuropharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108380214","display_name":"Kurt R Herkner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"K. R. Herkner","raw_affiliation_strings":["Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109931985","display_name":"BR Binder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. R. Binder","raw_affiliation_strings":["Vascular Biology, Center for Physiology and Pharmacology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology, Center for Physiology and Pharmacology, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048450444","display_name":"Daniela D. Pollak","orcid":"https://orcid.org/0000-0002-9584-6257","observed_orcids":["https://orcid.org/0000-0002-9584-6257"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D. D. Pollak","raw_affiliation_strings":["Neurophysiology and Neuropharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurophysiology and Neuropharmacology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048450444"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.196,"has_fulltext":true,"cited_by_count":183,"citation_normalized_percentile":{"value":0.95572917,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"31","issue":"25","first_page":"9075","last_page":"9083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/constant-darkness","display_name":"constant darkness","score":0.8500000238418579},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.9440000057220459},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7160000205039978},{"id":"https://openalex.org/keywords/light-deprivation","display_name":"light deprivation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hippocampal-cell-proliferation","display_name":"hippocampal cell proliferation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/clock-genes","display_name":"clock genes","score":0.718999981880188},{"id":"https://openalex.org/keywords/per2","display_name":"Per2","score":0.875},{"id":"https://openalex.org/keywords/npas2","display_name":"NPAS2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-1r1","display_name":"IL1R1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/il-6-knockout-mice","display_name":"IL-6 knockout mice","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8276726007461548},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6853319406509399},{"id":"https://openalex.org/C2779064383","wikidata":"https://www.wikidata.org/wiki/Q15323251","display_name":"PER2","level":5,"score":0.6139829158782959},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5732277035713196},{"id":"https://openalex.org/C2779027399","wikidata":"https://www.wikidata.org/wiki/Q204170","display_name":"Darkness","level":2,"score":0.550596296787262},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5194417834281921},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.487559974193573},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4697611331939697},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46729424595832825},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.4440286159515381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37254199385643005},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.3594893217086792},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3231956660747528},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.294433057308197},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2848459482192993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2650497853755951},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26189059019088745},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021081","descriptor_name":"Chronobiology Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D021081","descriptor_name":"Chronobiology Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1537-11.2011","doi":"https://doi.org/10.1523/jneurosci.1537-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1537-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/25/9075.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6623479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6623479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:21697358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21697358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1537-11.2011","doi":"https://doi.org/10.1523/jneurosci.1537-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1537-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/25/9075.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971474571.pdf","grobid_xml":"https://content.openalex.org/works/W1971474571.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W60325865","https://openalex.org/W100865822","https://openalex.org/W1605726257","https://openalex.org/W1965359283","https://openalex.org/W1967087306","https://openalex.org/W1968248096","https://openalex.org/W1976382352","https://openalex.org/W1981274951","https://openalex.org/W1984417371","https://openalex.org/W1984877838","https://openalex.org/W1987604172","https://openalex.org/W1988105902","https://openalex.org/W1992860227","https://openalex.org/W1993856151","https://openalex.org/W1994322615","https://openalex.org/W1994345197","https://openalex.org/W1996454121","https://openalex.org/W2001997781","https://openalex.org/W2007572060","https://openalex.org/W2010900435","https://openalex.org/W2011039340","https://openalex.org/W2013946239","https://openalex.org/W2014593621","https://openalex.org/W2018011543","https://openalex.org/W2019324493","https://openalex.org/W2021804141","https://openalex.org/W2027589906","https://openalex.org/W2033338676","https://openalex.org/W2034352381","https://openalex.org/W2037909938","https://openalex.org/W2038473038","https://openalex.org/W2043232041","https://openalex.org/W2047634684","https://openalex.org/W2058331036","https://openalex.org/W2058490717","https://openalex.org/W2058854303","https://openalex.org/W2065906084","https://openalex.org/W2069272625","https://openalex.org/W2074384301","https://openalex.org/W2082307168","https://openalex.org/W2083196423","https://openalex.org/W2089153051","https://openalex.org/W2097740790","https://openalex.org/W2099713879","https://openalex.org/W2103704610","https://openalex.org/W2103997793","https://openalex.org/W2117633457","https://openalex.org/W2120032880","https://openalex.org/W2121358117","https://openalex.org/W2122192348","https://openalex.org/W2126795224","https://openalex.org/W2128175779","https://openalex.org/W2132482183","https://openalex.org/W2133518193","https://openalex.org/W2143809989","https://openalex.org/W2148665968","https://openalex.org/W2151454086","https://openalex.org/W2153482623","https://openalex.org/W2154971711","https://openalex.org/W2157781186","https://openalex.org/W2197078876","https://openalex.org/W2279856945","https://openalex.org/W4413981594"],"related_works":["https://openalex.org/W2588186635","https://openalex.org/W2115086834","https://openalex.org/W3018326882","https://openalex.org/W2129457290","https://openalex.org/W4391480283","https://openalex.org/W2061809825","https://openalex.org/W1975588273","https://openalex.org/W3035119955","https://openalex.org/W2599746658","https://openalex.org/W1984877838"],"abstract_inverted_index":{"Substantial":[0],"experimental":[1],"evidence":[2,144],"indicates":[3],"a":[4,192,211],"major":[5],"role":[6,213],"for":[7,214],"the":[8,24,29,33,56,69,120,129,139,146,168,198,218,231,240],"circadian":[9],"system":[10],"in":[11,23,40,55,64,119,184,217,239],"mood":[12],"disorders.":[13],"Additionally,":[14],"proinflammatory":[15,72],"cytokines":[16],"have":[17,42],"been":[18,44],"proposed":[19],"to":[20,205],"be":[21],"involved":[22],"pathogenesis":[25],"of":[26,71,80,104,128,138,148,161,170,187,194,197,201,223,230,245],"depression.":[27,224,246],"However,":[28],"molecular":[30,232],"elements":[31,233],"determining":[32],"functional":[34],"interplay":[35],"between":[36],"these":[37],"two":[38],"systems":[39],"depression":[41],"not":[43],"described":[45],"as":[46],"yet.":[47],"Here":[48],"we":[49,142],"investigate":[50],"whether":[51],"long-term":[52],"light":[53],"deprivation":[54],"constant":[57,219,241],"darkness":[58,220,242],"(DD)":[59],"paradigm":[60],"affects":[61],"depression-like":[62,84,151,207],"behavior":[63],"mice":[65,82],"and":[66,108,110,122,133,163,166,236],"concomitantly":[67],"modulates":[68],"levels":[70,103,118,127,160],"cytokines.":[73],"We":[74,225],"find":[75],"that":[76,145],"after":[77],"4":[78],"weeks":[79],"DD,":[81],"display":[83],"behavior,":[85,152,208],"which":[86,209],"is":[87,99,182],"paralleled":[88],"by":[89],"reduced":[90],"hippocampal":[91,125,154,185],"cell":[92,155],"proliferation.":[93],"This":[94],"chronobiologically":[95],"induced":[96],"depressive":[97],"state":[98],"associated":[100],"with":[101,191],"elevated":[102],"plasma":[105,164],"IL-6":[106,109],"(interleukin-6)":[107],"Il1-R1":[111],"(interleukin":[112],"1":[113],"receptor,":[114],"type":[115],"I)":[116],"protein":[117,126],"hippocampus":[121],"also":[123],"alters":[124],"clock":[130,171],"genes":[131,200],"per2":[132],"npas2.":[134],"Using":[135],"pharmacological":[136],"blockers":[137],"NF-\u03baB":[140,177,180],"pathway,":[141],"provide":[143],"effects":[147],"DD":[149,188],"on":[150,153,157,167],"proliferation,":[156],"altered":[158],"expressional":[159],"brain":[162],"IL-6,":[165,195],"modulation":[169],"gene":[172],"expression":[173],"are":[174,203],"mediated":[175],"through":[176],"signaling.":[178],"Moreover,":[179],"activity":[181],"enhanced":[183],"tissue":[186],"mice.":[189],"Mice":[190],"deletion":[193],"one":[196],"target":[199],"NF-\u03baB,":[202],"resistant":[204],"DD-induced":[206],"suggests":[210],"pivotal":[212],"this":[215],"cytokine":[216],"mouse":[221,243],"model":[222,244],"here":[226],"first":[227],"describe":[228],"some":[229],"bridging":[234],"chronobiological":[235],"inflammatory":[237],"processes":[238]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
