{"id":"https://openalex.org/W1971405798","doi":"https://doi.org/10.1038/293481a0","title":"Production in B. subtilis of hepatitis B core antigen and of major antigen of foot and mouth disease virus","display_name":"Production in B. subtilis of hepatitis B core antigen and of major antigen of foot and mouth disease virus","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W1971405798","doi":"https://doi.org/10.1038/293481a0","mag":"1971405798","pmid":"https://pubmed.ncbi.nlm.nih.gov/6273732"},"language":"en","primary_location":{"id":"doi:10.1038/293481a0","doi":"https://doi.org/10.1038/293481a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/293481a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111624904","display_name":"K. G. Hardy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147244","display_name":"Biogen (Switzerland)","ror":"https://ror.org/04fg2k993","country_code":"CH","type":"company","lineage":["https://openalex.org/I1297540436","https://openalex.org/I4210147244"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kimber Hardy","raw_affiliation_strings":["Biogen SA, 3 route de Troinex, 1227, Carouge, Geneva, Switzerland","Biogen SA, Carouge, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen SA, 3 route de Troinex, 1227, Carouge, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210147244"]},{"raw_affiliation_string":"Biogen SA, Carouge, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210147244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111801413","display_name":"Stephen J. Stahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147244","display_name":"Biogen (Switzerland)","ror":"https://ror.org/04fg2k993","country_code":"CH","type":"company","lineage":["https://openalex.org/I1297540436","https://openalex.org/I4210147244"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephen Stahl","raw_affiliation_strings":["Biogen SA, 3 route de Troinex, 1227, Carouge, Geneva, Switzerland","Biogen SA, Carouge, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen SA, 3 route de Troinex, 1227, Carouge, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210147244"]},{"raw_affiliation_string":"Biogen SA, Carouge, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210147244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111580119","display_name":"Hans A. K\u00fcpper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147244","display_name":"Biogen (Switzerland)","ror":"https://ror.org/04fg2k993","country_code":"CH","type":"company","lineage":["https://openalex.org/I1297540436","https://openalex.org/I4210147244"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans K\u00fcpper","raw_affiliation_strings":["Biogen SA, 3 route de Troinex, 1227, Carouge, Geneva, Switzerland","Biogen SA, Carouge, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biogen SA, 3 route de Troinex, 1227, Carouge, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210147244"]},{"raw_affiliation_string":"Biogen SA, Carouge, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210147244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210147244"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":6.1058,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.96924723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"293","issue":"5832","first_page":"481","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hbcag","display_name":"HBcAg","score":0.9049999713897705},{"id":"https://openalex.org/keywords/foot-and-mouth-disease-virus","display_name":"foot-and-mouth disease virus","score":0.9660000205039978},{"id":"https://openalex.org/keywords/major-capsid-protein-vp1","display_name":"VP1 major capsid protein","score":0.7829999923706055},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8040000200271606},{"id":"https://openalex.org/keywords/plasmid-vectors","display_name":"plasmid vectors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/viral-antigen-production","display_name":"viral antigen production","score":0.5299999713897705},{"id":"https://openalex.org/keywords/natto","display_name":"natto","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.8043670654296875},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6736838817596436},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6114549040794373},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6079421043395996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5925655364990234},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.582073986530304},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5499370694160461},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5382909774780273},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.45367926359176636},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43406111001968384},{"id":"https://openalex.org/C2776151397","wikidata":"https://www.wikidata.org/wiki/Q1911079","display_name":"Foot-and-mouth disease virus","level":3,"score":0.41342371702194214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39109089970588684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09749853610992432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06627318263053894}],"mesh":[{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005537","descriptor_name":"Aphthovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006512","descriptor_name":"Hepatitis B Core Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/293481a0","doi":"https://doi.org/10.1038/293481a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/293481a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:6273732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6273732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1588718354","https://openalex.org/W1964847251","https://openalex.org/W1975435595","https://openalex.org/W1992595091","https://openalex.org/W2008148453","https://openalex.org/W2014141735","https://openalex.org/W2018949113","https://openalex.org/W2019645139","https://openalex.org/W2036424059","https://openalex.org/W2037622389","https://openalex.org/W2074476437","https://openalex.org/W2080187599","https://openalex.org/W2102838603","https://openalex.org/W2161095945","https://openalex.org/W2164253976","https://openalex.org/W2463267938","https://openalex.org/W4296765338"],"related_works":["https://openalex.org/W2132577749","https://openalex.org/W2292319531","https://openalex.org/W7120351450","https://openalex.org/W2907621117","https://openalex.org/W329596176","https://openalex.org/W1981943858","https://openalex.org/W7120861052","https://openalex.org/W653925353","https://openalex.org/W2059884467","https://openalex.org/W1982584779"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}