{"id":"https://openalex.org/W1971397652","doi":"https://doi.org/10.1016/s0959-8049(99)00033-7","title":"Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer","display_name":"Characterisation of tumour infiltrating lymphocytes and correlations with immunological surface molecules in colorectal cancer","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1971397652","doi":"https://doi.org/10.1016/s0959-8049(99)00033-7","mag":"1971397652","pmid":"https://pubmed.ncbi.nlm.nih.gov/10505031"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-8049(99)00033-7","doi":"https://doi.org/10.1016/s0959-8049(99)00033-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-8049(99)00033-7","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014201622","display_name":"Axel Cosmus Pyndt Diederichsen","orcid":"https://orcid.org/0000-0002-1285-4826","observed_orcids":["https://orcid.org/0000-0002-1285-4826"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"A.C.P Diederichsen","raw_affiliation_strings":["Department of Clinical Immunology, Odense University Hospital, Denmark. a.diederichsen@winsloew.ou.dk","Department of Clinical Immunology, Odense University Hospital, DK-5000 Odense CDenmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, Odense University Hospital, Denmark. a.diederichsen@winsloew.ou.dk","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Department of Clinical Immunology, Odense University Hospital, DK-5000 Odense CDenmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080686932","display_name":"Jesper Zeuthen","orcid":"https://orcid.org/0000-0002-6780-7568","observed_orcids":["https://orcid.org/0000-0002-6780-7568"]},"institutions":[{"id":"https://openalex.org/I4210148920","display_name":"Danish Cancer Society","ror":"https://ror.org/03ytt7k16","country_code":"DK","type":"nonprofit","lineage":["https://openalex.org/I4210148920"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J Zeuthen","raw_affiliation_strings":["Department of Tumour Cell Biology, Division of Cancer Biology, Danish Cancer Society, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumour Cell Biology, Division of Cancer Biology, Danish Cancer Society, Denmark","institution_ids":["https://openalex.org/I4210148920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014820923","display_name":"Peer Brehm Christensen","orcid":"https://orcid.org/0000-0003-1394-058X","observed_orcids":["https://orcid.org/0000-0003-1394-058X"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P.B Christensen","raw_affiliation_strings":["Department of Gastroenterological Surgery, Odense University Hospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Odense University Hospital, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012029324","display_name":"Tom Kristensen","orcid":"https://orcid.org/0000-0002-2131-4469","observed_orcids":["https://orcid.org/0000-0002-2131-4469"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T Kristensen","raw_affiliation_strings":["Department of Clinical Immunology, Odense University Hospital, DK-5000 Odense CDenmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, Odense University Hospital, DK-5000 Odense CDenmark","institution_ids":["https://openalex.org/I2801498763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014201622"],"corresponding_institution_ids":["https://openalex.org/I2801498763"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":0.3473,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.58790806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"5","first_page":"721","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6416000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.22120000422000885,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.10419999808073044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hla-class-i","display_name":"HLA class I","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.9800000190734863},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7089999914169312},{"id":"https://openalex.org/keywords/enzymatic-dissociation","display_name":"enzyme dissociation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.4970000088214874},{"id":"https://openalex.org/keywords/lymphocyte-anergy","display_name":"lymphocyte anergy","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.6694652438163757},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.662773609161377},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5699445009231567},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5660096406936646},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.552244246006012},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.522506058216095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5001246929168701},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.48919299244880676},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.43652796745300293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4016094207763672},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36247628927230835},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3513677716255188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32190075516700745},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3052579164505005},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29852795600891113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28014129400253296},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2182169258594513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19004592299461365},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10557317733764648},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06265300512313843},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005805","descriptor_name":"Genes, MHC Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016516","descriptor_name":"CD4-CD8 Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0959-8049(99)00033-7","doi":"https://doi.org/10.1016/s0959-8049(99)00033-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-8049(99)00033-7","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:10505031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10505031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer (Oxford, England : 1990)","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/0b26fee0-6fcf-11db-81a9-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/0b26fee0-6fcf-11db-81a9-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diederichsen, A C P, Zeuthen, J, Christensen, P B & Kristensen, T 1999, 'Characterisation of Tumour Infiltrating Lymphocytes and Correlations with Immunological Surface Molecules in Colorectal Cancer', European Journal of Cancer, vol. 35, no. 5, pp. 721-726.","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1556427392","https://openalex.org/W1970484905","https://openalex.org/W1972357604","https://openalex.org/W1977721439","https://openalex.org/W1985084304","https://openalex.org/W2005765588","https://openalex.org/W2006611100","https://openalex.org/W2009199474","https://openalex.org/W2010300855","https://openalex.org/W2037626742","https://openalex.org/W2058532626","https://openalex.org/W2063454166","https://openalex.org/W2063967700","https://openalex.org/W2068672112","https://openalex.org/W2068897967","https://openalex.org/W2074368989","https://openalex.org/W2076513209","https://openalex.org/W2164653479","https://openalex.org/W2412151250","https://openalex.org/W2418211263","https://openalex.org/W2419021807","https://openalex.org/W6716928877"],"related_works":["https://openalex.org/W2063967700","https://openalex.org/W2129728624","https://openalex.org/W2997880103","https://openalex.org/W4406028525","https://openalex.org/W3125157445","https://openalex.org/W2034192038","https://openalex.org/W2049784437","https://openalex.org/W2419021807","https://openalex.org/W3028343363","https://openalex.org/W3013873196"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}