{"id":"https://openalex.org/W1971369867","doi":"https://doi.org/10.1523/jneurosci.2107-09.2009","title":"Estradiol-Induced Estrogen Receptor-\u03b1 Trafficking","display_name":"Estradiol-Induced Estrogen Receptor-\u03b1 Trafficking","publication_year":2009,"publication_date":"2009-12-02","ids":{"openalex":"https://openalex.org/W1971369867","doi":"https://doi.org/10.1523/jneurosci.2107-09.2009","mag":"1971369867","pmid":"https://pubmed.ncbi.nlm.nih.gov/19955385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2836237"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2107-09.2009","doi":"https://doi.org/10.1523/jneurosci.2107-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2107-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/48/15323.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/29/48/15323.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061204824","display_name":"Galyna Bondar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galyna Bondar","raw_affiliation_strings":["Department of Neurobiology, Laboratory of Neuroendocrinology and Brian Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Laboratory of Neuroendocrinology and Brian Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kuo","raw_affiliation_strings":["Department of Neurobiology, Laboratory of Neuroendocrinology and Brian Research Institute, and","Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Laboratory of Neuroendocrinology and Brian Research Institute, and","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075191626","display_name":"Naheed Hamid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naheed Hamid","raw_affiliation_strings":["Department of Neurobiology , David Geffen School of Medicine at the University of California , Los Angeles , CA 90095-1763","Department of Neurobiology, Laboratory of Neuroendocrinology and Brian Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology , David Geffen School of Medicine at the University of California , Los Angeles , CA 90095-1763","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurobiology, Laboratory of Neuroendocrinology and Brian Research Institute, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029348051","display_name":"Paul E. Micevych","orcid":"https://orcid.org/0000-0002-9577-5874","observed_orcids":["https://orcid.org/0000-0002-9577-5874"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Micevych","raw_affiliation_strings":["Department of Neurobiology , Laboratory of Neuroendocrinology and Brian Research Institute , and","University of California\u2013Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology , Laboratory of Neuroendocrinology and Brian Research Institute , and","institution_ids":[]},{"raw_affiliation_string":"University of California\u2013Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":7.7506,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.97917319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"29","issue":"48","first_page":"15323","last_page":"15330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9570000171661377},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9819999933242798},{"id":"https://openalex.org/keywords/membrane-estrogen-receptor","display_name":"membrane estrogen receptor","score":0.6970000267028809},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptor-1a","display_name":"mGluR1a","score":0.8989999890327454},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.9020000100135803},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9509999752044678},{"id":"https://openalex.org/keywords/receptor-downregulation","display_name":"receptor down-regulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7129999995231628},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.7129999995231628},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.8549267053604126},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5949261784553528},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5807468295097351},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5497338771820068},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.46309423446655273},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4216950833797455},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.4183439016342163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41570544242858887},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4102991223335266},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3894503712654114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35359451174736023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3516440987586975},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24552834033966064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23901736736297607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06921002268791199},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077267","descriptor_name":"Fulvestrant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019921","descriptor_name":"Biotinylation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.2107-09.2009","doi":"https://doi.org/10.1523/jneurosci.2107-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2107-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/48/15323.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2836237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2836237","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:19955385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19955385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2107-09.2009","doi":"https://doi.org/10.1523/jneurosci.2107-09.2009","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2107-09.2009","pdf_url":"https://www.jneurosci.org/content/jneuro/29/48/15323.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3004710825","display_name":null,"funder_award_id":"HD-001281","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3552284603","display_name":null,"funder_award_id":"HD 042635","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3667970594","display_name":"UCLA Women's Reproductive Health Research Center","funder_award_id":"K12HD001281","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3773250293","display_name":"Physiology of hypothalamic neurosteroidal progesterone","funder_award_id":"R01HD042635","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971369867.pdf","grobid_xml":"https://content.openalex.org/works/W1971369867.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W206886781","https://openalex.org/W1507515137","https://openalex.org/W1529384397","https://openalex.org/W1575257247","https://openalex.org/W1778908591","https://openalex.org/W1799614702","https://openalex.org/W1963701331","https://openalex.org/W1968998907","https://openalex.org/W1969883008","https://openalex.org/W1971844132","https://openalex.org/W1980509664","https://openalex.org/W1980535385","https://openalex.org/W1984479644","https://openalex.org/W1985323260","https://openalex.org/W1987647696","https://openalex.org/W1988130277","https://openalex.org/W1988626741","https://openalex.org/W1990746420","https://openalex.org/W1995870796","https://openalex.org/W1998151899","https://openalex.org/W2001689132","https://openalex.org/W2003711003","https://openalex.org/W2007984040","https://openalex.org/W2012549407","https://openalex.org/W2016707584","https://openalex.org/W2020338570","https://openalex.org/W2021454655","https://openalex.org/W2024067647","https://openalex.org/W2025252016","https://openalex.org/W2025624761","https://openalex.org/W2027388925","https://openalex.org/W2030402917","https://openalex.org/W2031518606","https://openalex.org/W2032488362","https://openalex.org/W2035136845","https://openalex.org/W2038224182","https://openalex.org/W2039376139","https://openalex.org/W2059194678","https://openalex.org/W2060090078","https://openalex.org/W2060408479","https://openalex.org/W2065346432","https://openalex.org/W2067642579","https://openalex.org/W2070293233","https://openalex.org/W2076870890","https://openalex.org/W2077046953","https://openalex.org/W2082187626","https://openalex.org/W2085405074","https://openalex.org/W2101467600","https://openalex.org/W2105846317","https://openalex.org/W2105870463","https://openalex.org/W2110560495","https://openalex.org/W2134329464","https://openalex.org/W2144520335","https://openalex.org/W2150952188","https://openalex.org/W2155723654","https://openalex.org/W2169788816","https://openalex.org/W4232669935","https://openalex.org/W4233906629","https://openalex.org/W4245927460"],"related_works":["https://openalex.org/W2107554331","https://openalex.org/W1977813273","https://openalex.org/W4237104046","https://openalex.org/W1990746420","https://openalex.org/W1980509664","https://openalex.org/W1985323260","https://openalex.org/W1979134590","https://openalex.org/W1970231474","https://openalex.org/W2110560495","https://openalex.org/W1987916086"],"abstract_inverted_index":{"Estradiol":[0,86,141],"has":[1,53,197],"rapid":[2],"actions":[3],"in":[4,43,94,193],"the":[5,31,39,60,105,150,170,180,194,223,227,233],"CNS":[6],"that":[7,37,51,189,226],"are":[8,208],"mediated":[9],"by":[10,80,121,210],"membrane":[11,89,102,115,195,202,224],"estrogen":[12],"receptors":[13,25],"(ERs)":[14],"and":[15,83,107,146,168,196,204,212,220,240],"activate":[16],"cell":[17],"signaling":[18,29],"pathways":[19],"through":[20],"interaction":[21],"with":[22,123,130,149,156,161],"metabotropic":[23],"glutamate":[24],"(mGluRs).":[26],"Membrane-initiated":[27],"estradiol":[28,99,122,131,211,231],"increases":[30],"free":[32],"cytoplasmic":[33],"calcium":[34],"concentration":[35,229],"([Ca(2+)](i))":[36],"stimulates":[38],"synthesis":[40],"of":[41,91,104,114,182,206,217,222,230],"neuroprogesterone":[42],"astrocytes.":[44],"We":[45],"used":[46],"surface":[47,69],"biotinylation":[48,70],"to":[49,59,167,238],"demonstrate":[50,188],"ERalpha":[52,62,136,165,184,190,207,237],"an":[54,72,198],"extracellular":[55,199],"portion.":[56,200],"In":[57],"addition":[58],"full-length":[61],"[apparent":[63],"molecular":[64],"weight":[65],"(MW),":[66],"66":[67,106],"kDa],":[68],"labeled":[71],"ERalpha-immunoreactive":[73],"protein":[74],"(MW,":[75],"approximately":[76],"52":[77,108],"kDa)":[78],"identified":[79],"both":[81,92],"COOH-":[82],"NH(2)-directed":[84],"antibodies.":[85],"treatment":[87,129],"regulated":[88,209],"levels":[90,103,203],"proteins":[93],"parallel:":[95],"within":[96],"5":[97],"min,":[98],"significantly":[100,177],"increased":[101,120,143,178],"kDa":[109],"ERalpha.":[110],"Internalization,":[111],"a":[112,124],"measure":[113],"receptor":[116,139],"activation,":[117],"was":[118,175],"also":[119,142,176],"similar":[125],"time":[126,181],"course.":[127],"Continuous":[128],"for":[132],"24-48":[133],"h":[134],"reduced":[135],"levels,":[137],"suggesting":[138],"downregulation.":[140],"mGluR1a":[144,160,213],"trafficking":[145,166,218],"internalization,":[147],"consistent":[148],"proposed":[151],"ERalpha-mGluR1a":[152],"interaction.":[153],"Blocking":[154],"ER":[155],"ICI":[157],"182,780":[158],"or":[159],"LY":[162],"367385":[163],"prevented":[164],"from":[169],"membrane.":[171],"Estradiol-induced":[172],"[Ca(2+)](i)":[173],"flux":[174],"at":[179],"peak":[183],"activation/internalization.":[185],"These":[186],"results":[187],"is":[191],"present":[192],"Furthermore,":[201],"internalization":[205],"ligands.":[214],"The":[215],"pattern":[216],"into":[219],"out":[221],"suggests":[225],"changing":[228],"during":[232],"estrous":[234],"cycle":[235],"regulates":[236],"augment":[239],"then":[241],"terminate":[242],"membrane-initiated":[243],"signaling.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":19}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}