{"id":"https://openalex.org/W1971302204","doi":"https://doi.org/10.1073/pnas.88.2.350","title":"Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.","display_name":"Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.","publication_year":1991,"publication_date":"1991-01-15","ids":{"openalex":"https://openalex.org/W1971302204","doi":"https://doi.org/10.1073/pnas.88.2.350","mag":"1971302204","pmid":"https://pubmed.ncbi.nlm.nih.gov/1703295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/50808"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.88.2.350","doi":"https://doi.org/10.1073/pnas.88.2.350","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.88.2.350","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC50808","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061857523","display_name":"John J. O\u2019Shea","orcid":"https://orcid.org/0000-0002-6456-9752","observed_orcids":["https://orcid.org/0000-0002-6456-9752"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J J O'Shea","raw_affiliation_strings":["Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083498586","display_name":"Allan M. Weissman","orcid":"https://orcid.org/0000-0002-7865-7702","observed_orcids":["https://orcid.org/0000-0002-7865-7702"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Weissman","raw_affiliation_strings":["Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059402645","display_name":"Ian C. S. Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I C Kennedy","raw_affiliation_strings":["Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019215357","display_name":"John R. Ortaldo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R Ortaldo","raw_affiliation_strings":["Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Immunology, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2517,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.97218845,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"88","issue":"2","first_page":"350","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fc-gamma-receptor-iii","display_name":"Fc gamma receptor III","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.9739999771118164},{"id":"https://openalex.org/keywords/zeta-chain","display_name":"zeta chain","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.7099999785423279},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.902999997138977},{"id":"https://openalex.org/keywords/inositol-phospholipid-hydrolysis","display_name":"inositol phospholipid hydrolysis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/receptor-coupling","display_name":"receptor coupling","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6129899621009827},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.49344602227211},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.462923526763916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45792728662490845},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.45556285977363586},{"id":"https://openalex.org/C2779931124","wikidata":"https://www.wikidata.org/wiki/Q417823","display_name":"Fc receptor","level":3,"score":0.43473172187805176},{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.4213878810405731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40513473749160767},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38312074542045593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38032081723213196},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3319569230079651},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2897202968597412},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.20886299014091492},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.20290490984916687},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12404999136924744},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.07904165983200073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0703001320362091}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.88.2.350","doi":"https://doi.org/10.1073/pnas.88.2.350","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.88.2.350","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:46057","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC50808","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:50808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/50808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:1703295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1703295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:46057","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC50808","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1486719323","https://openalex.org/W1490734926","https://openalex.org/W1502628508","https://openalex.org/W1516065974","https://openalex.org/W1524473114","https://openalex.org/W1533232725","https://openalex.org/W1536681080","https://openalex.org/W1554943252","https://openalex.org/W1561731791","https://openalex.org/W1641011985","https://openalex.org/W1958125141","https://openalex.org/W1971376791","https://openalex.org/W1986656701","https://openalex.org/W1999298531","https://openalex.org/W2003293767","https://openalex.org/W2019300008","https://openalex.org/W2025935390","https://openalex.org/W2032046420","https://openalex.org/W2053949613","https://openalex.org/W2055464913","https://openalex.org/W2061806013","https://openalex.org/W2071573211","https://openalex.org/W2080476991","https://openalex.org/W2080966713","https://openalex.org/W2082496555","https://openalex.org/W2088215519","https://openalex.org/W2094126922","https://openalex.org/W2095213694","https://openalex.org/W2117006179","https://openalex.org/W2132853354","https://openalex.org/W2132857938","https://openalex.org/W2148330408","https://openalex.org/W2173828780","https://openalex.org/W2177673530","https://openalex.org/W2177985207","https://openalex.org/W2182452189","https://openalex.org/W2337281190","https://openalex.org/W2402990287","https://openalex.org/W2435318668","https://openalex.org/W2470768411","https://openalex.org/W2471078498","https://openalex.org/W4240903371"],"related_works":["https://openalex.org/W2185190166","https://openalex.org/W1594123023","https://openalex.org/W2127141367","https://openalex.org/W2080966713","https://openalex.org/W2007181639","https://openalex.org/W1667164869","https://openalex.org/W2030655955","https://openalex.org/W2093797065","https://openalex.org/W1990173454","https://openalex.org/W2015366690"],"abstract_inverted_index":{"The":[0],"zeta":[1,57,99,116,189,295],"chain":[2,58,100,117,190,296],"has":[3],"emerged":[4],"to":[5,60,130,137,149,157,251,264],"be":[6,61,84],"a":[7,102,131,150,154,205,265,298,305],"key":[8],"subunit":[9,35],"of":[10,23,48,75,91,113,174,187,199,214,218,228,310],"the":[11,24,45,49,56,64,72,98,114,122,126,158,188,197,223,244,275,287,294],"T-cell":[12,50,159,288],"antigen":[13,51,160,289],"receptor":[14,26,67,70,93,290],"with":[15,63,177,231],"central":[16],"roles":[17],"not":[18,210],"only":[19],"in":[20,29,38,120,153,167,212,274,283,291],"intracellular":[21],"assembly":[22],"multimeric":[25],"but":[27],"also":[28,235],"mediating":[30],"signal":[31],"transduction":[32],"events.":[33],"This":[34,255],"is":[36,101,147,249,262,297],"present":[37,256],"natural":[39],"killer":[40],"(NK)":[41],"cells":[42,176,230,285],"that":[43,105,125,172,243,258,269,301],"lack":[44],"other":[46,192],"subunits":[47],"receptor.":[52],"In":[53,95],"NK":[54,65,168,175,229,284],"cells,":[55,97,234],"appears":[59],"associated":[62],"Fc":[66,73,144,219,246,259,280],"[type":[68],"3":[69],"for":[71,86,308],"portion":[74],"IgG":[76],"(Fc":[77],"gamma":[78,145,180,220,247,260,281],"RIII":[79,146,181,221,248,261,282],"or":[80,204],"CD16)]":[81],"and":[82,202,286],"may":[83,302],"necessary":[85],"efficient":[87],"cell":[88],"surface":[89],"expression":[90],"this":[92,215],"complex.":[94],"T":[96,292],"prominent":[103],"substrate":[104],"becomes":[106],"phosphorylated":[107],"on":[108],"tyrosine":[109,185],"residues":[110],"after":[111],"occupancy":[112],"TCR;":[115],"phosphorylation":[118,166,186,213],"was":[119,128],"fact":[121],"first":[123],"evidence":[124],"TCR":[127],"coupled":[129,148,250,263],"protein-tyrosine":[132,151,266],"kinase":[133,152,267],"as":[134,136,196,304],"well":[135],"inositol":[138,252],"phospholipid":[139,253],"hydrolysis.":[140,254],"To":[141],"determine":[142],"if":[143],"manner":[155],"analogous":[156],"receptor,":[161],"we":[162],"investigated":[163],"ligand-dependent":[164],"zeta-chain":[165,237],"cells.":[169],"We":[170],"observed":[171],"activation":[173],"an":[178],"anti-Fc":[179],"monoclonal":[182],"antibody":[183],"induced":[184,236],"whereas":[191],"activating":[193],"stimuli,":[194],"such":[195],"combination":[198],"phorbol":[200],"ester":[201],"ionomycin":[203],"lymphokine,":[206],"interleukin":[207],"2,":[208],"did":[209],"result":[211],"protein.":[216],"Perturbation":[217],"by":[222,279],"more":[224],"physiological":[225],"stimulus,":[226],"incubation":[227],"antibody-coated":[232],"target":[233],"phosphorylation.":[238],"Previous":[239],"data":[240],"have":[241],"indicated":[242],"NK-cell":[245],"finding":[257],"illustrates":[268],"there":[270],"are":[271],"significant":[272],"similarities":[273],"signaling":[276],"pathways":[277],"activated":[278],"cells;":[293],"common":[299],"element":[300],"serve":[303],"coupling":[306],"protein":[307],"both":[309],"these":[311],"receptors.":[312]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}