{"id":"https://openalex.org/W1971293030","doi":"https://doi.org/10.1155/2009/132041","title":"Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use","display_name":"Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1971293030","doi":"https://doi.org/10.1155/2009/132041","mag":"1971293030","pmid":"https://pubmed.ncbi.nlm.nih.gov/19946400","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2777303"},"language":"en","primary_location":{"id":"doi:10.1155/2009/132041","doi":"https://doi.org/10.1155/2009/132041","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2009/132041","pdf_url":"https://ijpeonline.biomedcentral.com/counter/pdf/10.1155/2009/132041","source":{"id":"https://openalex.org/S82353828","display_name":"International Journal of Pediatric Endocrinology","issn_l":"1687-9848","issn":["1687-9848","1687-9856"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pediatric Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ijpeonline.biomedcentral.com/counter/pdf/10.1155/2009/132041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064333133","display_name":"Scott A. Rivkees","orcid":"https://orcid.org/0000-0001-9920-1109","observed_orcids":["https://orcid.org/0000-0001-9920-1109"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott A. Rivkees","raw_affiliation_strings":["Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA","Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Pediatric Thyroid Center, Yale University School of Medicine, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023758717","display_name":"Donald R. Mattison","orcid":"https://orcid.org/0000-0001-5623-0874","observed_orcids":["https://orcid.org/0000-0001-5623-0874"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R. Mattison","raw_affiliation_strings":["Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA","Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Obstetric and Pediatric Pharmacology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064333133"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":6.9494,"has_fulltext":true,"cited_by_count":136,"citation_normalized_percentile":{"value":0.98229533,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2009","issue":"1","first_page":"1","last_page":"132041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.7289999723434448},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7509999871253967},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.9760000109672546},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.8050000071525574},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7710000276565552},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.9561495780944824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8443975448608398},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.770100474357605},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5475425124168396},{"id":"https://openalex.org/C2776606491","wikidata":"https://www.wikidata.org/wiki/Q1365501","display_name":"Antithyroid agent","level":4,"score":0.5112853050231934},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4568423330783844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4492361843585968},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44435662031173706},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4241983890533447},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.36413365602493286},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28979218006134033},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15971145033836365},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.06979161500930786}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2009/132041","doi":"https://doi.org/10.1155/2009/132041","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2009/132041","pdf_url":"https://ijpeonline.biomedcentral.com/counter/pdf/10.1155/2009/132041","source":{"id":"https://openalex.org/S82353828","display_name":"International Journal of Pediatric Endocrinology","issn_l":"1687-9848","issn":["1687-9848","1687-9856"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pediatric Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1186/1687-9856-2009-132041","doi":"https://doi.org/10.1186/1687-9856-2009-132041","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1687-9856-2009-132041","pdf_url":null,"source":{"id":"https://openalex.org/S82353828","display_name":"International Journal of Pediatric Endocrinology","issn_l":"1687-9848","issn":["1687-9848","1687-9856"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pediatric Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2777303","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2777303","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Pediatr Endocrinol","raw_type":"Text"},{"id":"pmid:19946400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19946400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pediatric endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.9770","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.9770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b6/7f/Int_J_Pediatr_Endocrinol_2009_Apr_21_2009_132041.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1155/2009/132041","doi":"https://doi.org/10.1155/2009/132041","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2009/132041","pdf_url":"https://ijpeonline.biomedcentral.com/counter/pdf/10.1155/2009/132041","source":{"id":"https://openalex.org/S82353828","display_name":"International Journal of Pediatric Endocrinology","issn_l":"1687-9848","issn":["1687-9848","1687-9856"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pediatric Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971293030.pdf","grobid_xml":"https://content.openalex.org/works/W1971293030.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W49768561","https://openalex.org/W73116297","https://openalex.org/W81099855","https://openalex.org/W87732535","https://openalex.org/W90698309","https://openalex.org/W97127403","https://openalex.org/W101085872","https://openalex.org/W113716927","https://openalex.org/W124341234","https://openalex.org/W140977188","https://openalex.org/W271500561","https://openalex.org/W1535496843","https://openalex.org/W1539528241","https://openalex.org/W1559373545","https://openalex.org/W1764534087","https://openalex.org/W1824595036","https://openalex.org/W1827341545","https://openalex.org/W1964023434","https://openalex.org/W1965484999","https://openalex.org/W1970761739","https://openalex.org/W1972779461","https://openalex.org/W1975290953","https://openalex.org/W1979898289","https://openalex.org/W1986415301","https://openalex.org/W1988470435","https://openalex.org/W1992904825","https://openalex.org/W2000650727","https://openalex.org/W2009400616","https://openalex.org/W2014302771","https://openalex.org/W2015422744","https://openalex.org/W2017103251","https://openalex.org/W2021080052","https://openalex.org/W2029549246","https://openalex.org/W2029919970","https://openalex.org/W2035898842","https://openalex.org/W2037052008","https://openalex.org/W2042813379","https://openalex.org/W2044469099","https://openalex.org/W2046379714","https://openalex.org/W2047788194","https://openalex.org/W2050642593","https://openalex.org/W2052408653","https://openalex.org/W2053586459","https://openalex.org/W2057060651","https://openalex.org/W2057657462","https://openalex.org/W2057705173","https://openalex.org/W2061508123","https://openalex.org/W2064178711","https://openalex.org/W2068693106","https://openalex.org/W2068922012","https://openalex.org/W2069645466","https://openalex.org/W2072928625","https://openalex.org/W2080637533","https://openalex.org/W2084256663","https://openalex.org/W2084828244","https://openalex.org/W2086621867","https://openalex.org/W2088022002","https://openalex.org/W2093574847","https://openalex.org/W2093656574","https://openalex.org/W2101871197","https://openalex.org/W2102551136","https://openalex.org/W2105937598","https://openalex.org/W2112711805","https://openalex.org/W2119617836","https://openalex.org/W2134617075","https://openalex.org/W2139900098","https://openalex.org/W2140998061","https://openalex.org/W2142623819","https://openalex.org/W2151740080","https://openalex.org/W2151759234","https://openalex.org/W2155022244","https://openalex.org/W2160412781","https://openalex.org/W2172042561","https://openalex.org/W2264299179","https://openalex.org/W2283886653","https://openalex.org/W2335796212","https://openalex.org/W2403818308","https://openalex.org/W2408040242","https://openalex.org/W2414157379","https://openalex.org/W2470438318","https://openalex.org/W2565315295","https://openalex.org/W2768509643","https://openalex.org/W2993295660","https://openalex.org/W3026171110","https://openalex.org/W4243225672","https://openalex.org/W4255502099","https://openalex.org/W4255762715","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7098348940","https://openalex.org/W2107941115","https://openalex.org/W2029811445","https://openalex.org/W2029549246","https://openalex.org/W1827341545","https://openalex.org/W2057705173","https://openalex.org/W2027386028","https://openalex.org/W2037195934","https://openalex.org/W2141915710","https://openalex.org/W1993020937"],"abstract_inverted_index":{"Propylthiouracil":[0],"(PTU)":[1],"was":[2],"introduced":[3],"for":[4,10,157,172],"clinical":[5],"use":[6,181],"in":[7,45,80,109,128,142,177,182,190],"July":[8],"1947":[9],"Graves'":[11],"disease":[12],"(GD)":[13],"treatment.":[14],"Over":[15],"the":[16,48,81,173],"60":[17],"years":[18],"that":[19,64],"this":[20,185],"medication":[21,186],"has":[22],"been":[23],"used,":[24],"reports":[25],"of":[26,54,88,100,114,133,175,192],"PTU-related":[27],"liver":[28,103,119,134,148,159],"failure":[29,104],"and":[30,57,84,136],"death":[31],"have":[32],"accumulated.":[33],"On":[34],"October":[35],"28,":[36],"2008,":[37],"an":[38],"expert":[39],"panel":[40],"evaluated":[41],"PTU":[42,163,180],"drug":[43],"safety":[44],"children":[46,115,144,183],"at":[47,125,154],"Eunice":[49],"Kennedy":[50],"Shriver":[51],"National":[52],"Institute":[53],"Child":[55],"Health":[56],"Human":[58],"Development":[59],"(NICHD)":[60],"It":[61],"is":[62,105,121,139],"estimated":[63,106,122],"about":[65],"4000":[66],"pediatric":[67,89],"patients":[68,90],"per":[69],"year":[70],"with":[71,76,91,96],"GD":[72,92,176],"are":[73,93],"being":[74,94],"treated":[75,95],"antithyroid":[77],"drugs":[78],"(ATDs)":[79],"United":[82],"States,":[83],"up":[85],"to":[86,123,152],"30%":[87],"PTU.":[97],"The":[98,112],"risk":[99,156],"severe":[101],"PTU-induced":[102,118,158],"as":[107,168],"1":[108,127],"2000-4000":[110],"children.":[111,178],"number":[113],"developing":[116],"reversible":[117],"injury":[120,160],"be":[124,153,166,188],"least":[126],"200.":[129],"Routine":[130],"biochemical":[131],"surveillance":[132],"function":[135],"hepatocellular":[137],"integrity":[138],"not":[140,165],"useful":[141],"identifying":[143],"who":[145],"will":[146],"develop":[147],"failure.":[149],"Children":[150],"appear":[151],"higher":[155],"than":[161],"adults.":[162],"should":[164,187],"used":[167],"first":[169],"line":[170],"therapy":[171],"treatment":[174],"Current":[179],"taking":[184],"stopped":[189],"favor":[191],"alternate":[193],"therapies.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}