{"id":"https://openalex.org/W1971285113","doi":"https://doi.org/10.1016/j.cub.2008.05.045","title":"Aven-Dependent Activation of ATM Following DNA Damage","display_name":"Aven-Dependent Activation of ATM Following DNA Damage","publication_year":2008,"publication_date":"2008-06-20","ids":{"openalex":"https://openalex.org/W1971285113","doi":"https://doi.org/10.1016/j.cub.2008.05.045","mag":"1971285113","pmid":"https://pubmed.ncbi.nlm.nih.gov/18571408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2691717"},"language":"en","primary_location":{"id":"doi:10.1016/j.cub.2008.05.045","doi":"https://doi.org/10.1016/j.cub.2008.05.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2008.05.045","pdf_url":"http://www.cell.com/article/S0960982208007161/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0960982208007161/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010357438","display_name":"Jessie Yanxiang Guo","orcid":"https://orcid.org/0000-0001-9212-7954","observed_orcids":["https://orcid.org/0000-0001-9212-7954"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie Yanxiang Guo","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072173154","display_name":"Ayumi Yamada","orcid":"https://orcid.org/0000-0002-6085-8928","observed_orcids":["https://orcid.org/0000-0002-6085-8928"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayumi Yamada","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029992514","display_name":"Taisuke Kajino","orcid":"https://orcid.org/0000-0002-4826-7690","observed_orcids":["https://orcid.org/0000-0002-4826-7690"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taisuke Kajino","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062312202","display_name":"Judy Qiju Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Qiju Wu","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087518542","display_name":"Wanli Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanli Tang","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110089678","display_name":"Christopher D. Freel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Freel","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103178165","display_name":"Junjie Feng","orcid":"https://orcid.org/0009-0002-0405-1457","observed_orcids":["https://orcid.org/0009-0002-0405-1457","https://orcid.org/0000-0002-7878-3231"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junjie Feng","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108359400","display_name":"B. Nelson Chau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Nelson Chau","raw_affiliation_strings":["Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006973556","display_name":"Michael Zhuo Wang","orcid":"https://orcid.org/0000-0003-2494-4172","observed_orcids":["https://orcid.org/0000-0003-2494-4172"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Zhuo Wang","raw_affiliation_strings":["School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078928975","display_name":"Seth S. Margolis","orcid":"https://orcid.org/0000-0002-1873-0330","observed_orcids":["https://orcid.org/0000-0002-1873-0330"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth S. Margolis","raw_affiliation_strings":["Division of Neuroscience, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109931581","display_name":"Hae Yong Yoo","orcid":"https://orcid.org/0000-0002-3158-5684","observed_orcids":["https://orcid.org/0000-0002-3158-5684"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hae Yong Yoo","raw_affiliation_strings":["Division of Biology, California Institute of Technology, Pasadena, California 91125"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology, Pasadena, California 91125","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110871511","display_name":"Xiao-Fan Wang","orcid":"https://orcid.org/0009-0005-6440-9205","observed_orcids":["https://orcid.org/0009-0005-6440-9205"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Fan Wang","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087914047","display_name":"William G. Dunphy","orcid":"https://orcid.org/0000-0001-7598-8939","observed_orcids":["https://orcid.org/0000-0001-7598-8939"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G. Dunphy","raw_affiliation_strings":["Division of Biology, California Institute of Technology, Pasadena, California 91125"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology, Pasadena, California 91125","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054107860","display_name":"Pablo M. Irusta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo M. Irusta","raw_affiliation_strings":["Department of Human Science, Georgetown University Medical Center, Georgetown University, Washington, D.C. 20057","Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Science, Georgetown University Medical Center, Georgetown University, Washington, D.C. 20057","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]},{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029722271","display_name":"J. Marie Hardwick","orcid":"https://orcid.org/0000-0002-4847-2045","observed_orcids":["https://orcid.org/0000-0002-4847-2045"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Marie Hardwick","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205","Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053532303","display_name":"Sally A. Kornbluth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sally Kornbluth","raw_affiliation_strings":["Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5053532303"],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":2.8164,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.91235704,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"13","first_page":"933","last_page":"942"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aven","display_name":"Aven","score":0.9259999990463257},{"id":"https://openalex.org/keywords/atm-kinase-activation","display_name":"ATM kinase activation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9480000138282776},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8539999723434448},{"id":"https://openalex.org/keywords/positive-feedback-loop","display_name":"positive feedback loop","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mre11-rad50-nbs1","display_name":"Mre11-Rad50-Nbs1","score":0.847000002861023},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mitotic-entry","display_name":"mitotic entry","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dna-damage-signaling","display_name":"DNA damage signaling","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.779410719871521},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.746780276298523},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6180931329727173},{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.5362747311592102},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5222707390785217},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5219923257827759},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.49280670285224915},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4655379056930542},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.4646992087364197},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44760626554489136},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44275909662246704},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37123748660087585},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3704662322998047},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.25320276618003845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23671451210975647},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23038989305496216}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cub.2008.05.045","doi":"https://doi.org/10.1016/j.cub.2008.05.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2008.05.045","pdf_url":"http://www.cell.com/article/S0960982208007161/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:18571408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18571408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2691717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2691717","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Biol","raw_type":"Text"},{"id":"mag:2593875227","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/current-biology/pdf/S0960-9822(08)00716-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.cub.2008.05.045","doi":"https://doi.org/10.1016/j.cub.2008.05.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cub.2008.05.045","pdf_url":"http://www.cell.com/article/S0960982208007161/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2529503834","display_name":"Rad17 - & p53-mediated apoptosis pathways in response to DNA damage","funder_award_id":"R01CA123250","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2895830334","display_name":null,"funder_award_id":"R01 NS34704","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3513414714","display_name":"Control of Mitotic Entry by Regulators of Cdc2","funder_award_id":"R01GM067225","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G409990859","display_name":"Role of ATR in Cell Cycle Checkpoints","funder_award_id":"R01GM070891","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4136873181","display_name":"Control of Cell Cycle Transitions","funder_award_id":"R01GM043974","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5240644925","display_name":"\"Conserved Cell Death Pathways in Mammals and Yeast\"","funder_award_id":"R01GM077875","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5755752948","display_name":"Regulation of Apoptosis by Bcl-xL and other factors","funder_award_id":"R01NS037402","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7015827075","display_name":"Regulation of Viral Infections by Cellular Genes","funder_award_id":"R01NS034175","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7326787904","display_name":null,"funder_award_id":"RO1 NS34704","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8421903855","display_name":"Vaccine-enhanced respiratory syncytial virus disease","funder_award_id":"R01AI054952","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8841381945","display_name":"Inhibition  of Cytochrome c-induced Caspase Activation","funder_award_id":"R01CA102707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000114863","display_name":null,"funder_award_id":"GM043974","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000215643","display_name":null,"funder_award_id":"RO1 GM043974","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000257729","display_name":null,"funder_award_id":"RO1 AI54952","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G935457845","display_name":null,"funder_award_id":"R0I GM67225","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971285113.pdf","grobid_xml":"https://content.openalex.org/works/W1971285113.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W171936907","https://openalex.org/W1420696562","https://openalex.org/W1491129208","https://openalex.org/W1574122284","https://openalex.org/W1677118171","https://openalex.org/W1923812684","https://openalex.org/W1969308341","https://openalex.org/W1970209924","https://openalex.org/W1991444138","https://openalex.org/W1992848268","https://openalex.org/W1994803892","https://openalex.org/W1995294841","https://openalex.org/W1996799079","https://openalex.org/W1999554125","https://openalex.org/W2010051771","https://openalex.org/W2010895845","https://openalex.org/W2014825777","https://openalex.org/W2017695210","https://openalex.org/W2019379230","https://openalex.org/W2022569128","https://openalex.org/W2022811243","https://openalex.org/W2029479878","https://openalex.org/W2043027414","https://openalex.org/W2043136696","https://openalex.org/W2045526190","https://openalex.org/W2048990794","https://openalex.org/W2050039745","https://openalex.org/W2068359474","https://openalex.org/W2076314401","https://openalex.org/W2114480393","https://openalex.org/W2116092803","https://openalex.org/W2121026248","https://openalex.org/W2126686878","https://openalex.org/W2127372435","https://openalex.org/W2127849733","https://openalex.org/W2128252882","https://openalex.org/W2133631672","https://openalex.org/W2136277289","https://openalex.org/W2138430171","https://openalex.org/W2140439403","https://openalex.org/W2142146322","https://openalex.org/W2147288798","https://openalex.org/W2147971204","https://openalex.org/W2148283360","https://openalex.org/W2152884467","https://openalex.org/W2154141161","https://openalex.org/W2169630006","https://openalex.org/W2169911836","https://openalex.org/W2210663276","https://openalex.org/W2399613612","https://openalex.org/W2401556390","https://openalex.org/W6640193225","https://openalex.org/W7100361558"],"related_works":["https://openalex.org/W2593875227","https://openalex.org/W2159423338","https://openalex.org/W2068359474","https://openalex.org/W2045164156","https://openalex.org/W7095510653","https://openalex.org/W1974070281","https://openalex.org/W4249058722","https://openalex.org/W4248728438","https://openalex.org/W3106626760","https://openalex.org/W4238263482"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}