{"id":"https://openalex.org/W1971235233","doi":"https://doi.org/10.1074/jbc.m113.503904","title":"Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease","display_name":"Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease","publication_year":2013,"publication_date":"2013-10-18","ids":{"openalex":"https://openalex.org/W1971235233","doi":"https://doi.org/10.1074/jbc.m113.503904","mag":"1971235233","pmid":"https://pubmed.ncbi.nlm.nih.gov/24136196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3861644"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.503904","doi":"https://doi.org/10.1074/jbc.m113.503904","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.503904","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m113.503904","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026913903","display_name":"Shaowu Cheng","orcid":"https://orcid.org/0000-0001-9059-4727","observed_orcids":["https://orcid.org/0000-0001-9059-4727"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaowu Cheng","raw_affiliation_strings":["Departments of Experimental and Clinical Pharmacology University of Minnesota, Minneapolis, MN, USA","Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Experimental and Clinical Pharmacology University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108880324","display_name":"Dongfeng Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongfeng Cao","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039354911","display_name":"David A. Hottman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Hottman","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028963541","display_name":"Li\u2010Lian Yuan","orcid":"https://orcid.org/0000-0001-7787-576X","observed_orcids":["https://orcid.org/0000-0001-7787-576X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LiLian Yuan","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038969060","display_name":"Martin O. Berg\u00f6","orcid":"https://orcid.org/0000-0002-6915-7140","observed_orcids":["https://orcid.org/0000-0002-6915-7140"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Martin O. Bergo","raw_affiliation_strings":["Sahlgrenska Cancer Center, Institute of Medicine, University of Gothenburg, S-41390 Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sahlgrenska Cancer Center, Institute of Medicine, University of Gothenburg, S-41390 Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100435361","display_name":"Ling Li","orcid":"https://orcid.org/0000-0002-9245-7387","observed_orcids":["https://orcid.org/0000-0002-9245-7387"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ling Li","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100435361"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.2415,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.72772392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"288","issue":"50","first_page":"35952","last_page":"35960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8059999942779541},{"id":"https://openalex.org/keywords/protein-farnesyltransferase","display_name":"farnesyltransferase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-prenylation","display_name":"protein prenylation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/protein-farnesylation","display_name":"farnesylation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/geranylgeranylation","display_name":"geranylgeranylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.8450000286102295},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.843999981880188},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.746999979019165},{"id":"https://openalex.org/keywords/heterozygous-deletion","display_name":"heterozygous deletion","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.850898265838623},{"id":"https://openalex.org/C2778396349","wikidata":"https://www.wikidata.org/wiki/Q410994","display_name":"Farnesyltransferase","level":4,"score":0.7686183452606201},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.634853720664978},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.5899957418441772},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5086046457290649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5066786408424377},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.4930889308452606},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.47764861583709717},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4718494415283203},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4274471402168274},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3781850039958954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3501307964324951},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25835561752319336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1905018389225006},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16921287775039673},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12296321988105774},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.10898381471633911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1034102737903595},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m113.503904","doi":"https://doi.org/10.1074/jbc.m113.503904","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.503904","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3232152","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3861644","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24136196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24136196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3861644","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3861644/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.503904","doi":"https://doi.org/10.1074/jbc.m113.503904","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.503904","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4272751708","display_name":"Protective Mechanisms of Statins in Alzheimer's Disease","funder_award_id":"R01AG031846","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1487258982","https://openalex.org/W1853254255","https://openalex.org/W1966848219","https://openalex.org/W1970055334","https://openalex.org/W1973276273","https://openalex.org/W1973432881","https://openalex.org/W1974040473","https://openalex.org/W1975671148","https://openalex.org/W1982589658","https://openalex.org/W1983164821","https://openalex.org/W1990095100","https://openalex.org/W1990460495","https://openalex.org/W1993820843","https://openalex.org/W1996709343","https://openalex.org/W1999607830","https://openalex.org/W2001361004","https://openalex.org/W2001629507","https://openalex.org/W2003898971","https://openalex.org/W2004896472","https://openalex.org/W2005031405","https://openalex.org/W2007696560","https://openalex.org/W2008337884","https://openalex.org/W2013382634","https://openalex.org/W2015034968","https://openalex.org/W2021707184","https://openalex.org/W2029040938","https://openalex.org/W2030324488","https://openalex.org/W2030930681","https://openalex.org/W2034038074","https://openalex.org/W2038140836","https://openalex.org/W2048526645","https://openalex.org/W2049186585","https://openalex.org/W2055911520","https://openalex.org/W2062223404","https://openalex.org/W2072435649","https://openalex.org/W2084604930","https://openalex.org/W2084820723","https://openalex.org/W2091043188","https://openalex.org/W2095816971","https://openalex.org/W2102494086","https://openalex.org/W2107272456","https://openalex.org/W2107288853","https://openalex.org/W2128392882","https://openalex.org/W2130690907","https://openalex.org/W2143955562","https://openalex.org/W2218459761","https://openalex.org/W2752287204","https://openalex.org/W4242397592"],"related_works":["https://openalex.org/W3185610770","https://openalex.org/W1966848219","https://openalex.org/W4294104546","https://openalex.org/W1974040473","https://openalex.org/W2538736652","https://openalex.org/W1982373527","https://openalex.org/W2800620204","https://openalex.org/W2791826543","https://openalex.org/W2086348133","https://openalex.org/W2171349254"],"abstract_inverted_index":{"Isoprenoids":[0],"and":[1,23,40,70,91,93,97,112,120,127,135],"prenylated":[2],"proteins":[3],"have":[4],"been":[5],"implicated":[6],"in":[7,43,73,100,132],"the":[8,30,34,44,53,64,108],"pathophysiology":[9],"of":[10,33,46,55,59,66,82,86,105,110,140],"Alzheimer":[11],"disease":[12],"(AD),":[13],"including":[14],"amyloid-\u03b2":[15,67],"precursor":[16],"protein":[17,36,141],"metabolism,":[18],"Tau":[19],"phosphorylation,":[20],"synaptic":[21],"plasticity,":[22],"neuroinflammation.":[24],"However,":[25],"little":[26],"is":[27],"known":[28],"about":[29],"relative":[31],"importance":[32],"two":[35],"prenyltransferases,":[37],"farnesyltransferase":[38],"(FT)":[39],"geranylgeranyltransferase-1":[41],"(GGT),":[42],"pathogenesis":[45,134],"AD.":[47,83,151],"In":[48],"this":[49],"study,":[50],"we":[51],"defined":[52],"impact":[54,117],"deleting":[56],"one":[57],"copy":[58],"FT":[60,87],"or":[61],"GGT":[62,106],"on":[63,118],"development":[65],"(A\u03b2)-associated":[68],"neuropathology":[69],"learning/memory":[71],"impairments":[72],"APPPS1":[74,101],"double":[75],"transgenic":[76],"mice,":[77],"a":[78,145],"well":[79],"established":[80],"model":[81],"Heterozygous":[84,103],"deletion":[85,104],"reduced":[88,107],"A\u03b2":[89,111],"deposition":[90],"neuroinflammation":[92,113],"rescued":[94],"spatial":[95],"learning":[96,119],"memory":[98],"function":[99],"mice.":[102],"levels":[109],"but":[114],"had":[115],"no":[116],"memory.":[121],"These":[122],"results":[123],"document":[124],"that":[125,137],"farnesylation":[126,142],"geranylgeranylation":[128],"play":[129],"differential":[130],"roles":[131],"AD":[133],"suggest":[136],"specific":[138],"inhibition":[139],"could":[143],"be":[144],"potential":[146],"strategy":[147],"for":[148],"effectively":[149],"treating":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}