{"id":"https://openalex.org/W1971199672","doi":"https://doi.org/10.1016/s0168-8278(05)80062-5","title":"Renal and hormonal responses to repeated treatment with enalapril in non-azotemic cirrhosis with ascites","display_name":"Renal and hormonal responses to repeated treatment with enalapril in non-azotemic cirrhosis with ascites","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1971199672","doi":"https://doi.org/10.1016/s0168-8278(05)80062-5","mag":"1971199672","pmid":"https://pubmed.ncbi.nlm.nih.gov/8006403"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(05)80062-5","doi":"https://doi.org/10.1016/s0168-8278(05)80062-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(05)80062-5","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014364578","display_name":"Akihiro Ohnishi","orcid":"https://orcid.org/0000-0002-4295-3649","observed_orcids":["https://orcid.org/0000-0002-4295-3649"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akihiro Ohnishi","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, Jikei University School of Medicine, Tokyo, Japan","Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078824924","display_name":"Shigeto MURAKAMI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Murakami","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045604130","display_name":"Makoto Harada","orcid":"https://orcid.org/0000-0002-6209-7683","observed_orcids":["https://orcid.org/0000-0002-6209-7683"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Harada","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058495707","display_name":"Kazuhiro Osaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Osaka","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567431","display_name":"Kohji Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohji Wada","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044684549","display_name":"Masazumi Odagiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masazumi Odagiri","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006896049","display_name":"Takumi TSUCHIYA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Tsuchiya","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110248838","display_name":"Teruji Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruji Tanaka","raw_affiliation_strings":["Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (I), Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014364578"],"corresponding_institution_ids":["https://openalex.org/I115498069"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.5626,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.67840482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"2","first_page":"223","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enalapril","display_name":"enalapril","score":0.9959999918937683},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/renal-sodium-retention","display_name":"renal sodium retention","score":0.6899999976158142},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.9229999780654907},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.4740000069141388},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.7990000247955322},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6629999876022339},{"id":"https://openalex.org/keywords/urinary-prostaglandins","display_name":"urinary prostaglandins","score":0.7429999709129333},{"id":"https://openalex.org/keywords/kallikrein","display_name":"kallikrein","score":0.9649999737739563},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.8040000200271606},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hormonal-response","display_name":"endocrine response","score":0.3569999933242798},{"id":"https://openalex.org/keywords/repeated-dosing","display_name":"repeated dosing","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.8328382968902588},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7182940244674683},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.7115726470947266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7073251008987427},{"id":"https://openalex.org/C2909726219","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril Maleate","level":5,"score":0.703113853931427},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6775023341178894},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.6499833464622498},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.646268367767334},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6237151026725769},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.5841403007507324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5010290145874023},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.44592559337615967},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.3790607452392578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.339130699634552}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001201","descriptor_name":"Ascites","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009318","descriptor_name":"Natriuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0168-8278(05)80062-5","doi":"https://doi.org/10.1016/s0168-8278(05)80062-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(05)80062-5","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},{"id":"pmid:8006403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8006403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324809","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W74854850","https://openalex.org/W120614388","https://openalex.org/W607288526","https://openalex.org/W1623673702","https://openalex.org/W1893127269","https://openalex.org/W1911188572","https://openalex.org/W1968355348","https://openalex.org/W1979651804","https://openalex.org/W1986742240","https://openalex.org/W1987491491","https://openalex.org/W1998224752","https://openalex.org/W1999994807","https://openalex.org/W2004301238","https://openalex.org/W2011169857","https://openalex.org/W2018059421","https://openalex.org/W2020188379","https://openalex.org/W2028919494","https://openalex.org/W2037813060","https://openalex.org/W2038010867","https://openalex.org/W2044158648","https://openalex.org/W2044530558","https://openalex.org/W2046947037","https://openalex.org/W2047741519","https://openalex.org/W2053849378","https://openalex.org/W2063040213","https://openalex.org/W2067929203","https://openalex.org/W2070095270","https://openalex.org/W2074468494","https://openalex.org/W2080950711","https://openalex.org/W2083179267","https://openalex.org/W2085147947","https://openalex.org/W2102199589","https://openalex.org/W2104649857","https://openalex.org/W2105038748","https://openalex.org/W2110580832","https://openalex.org/W2140584478","https://openalex.org/W2163893184","https://openalex.org/W2186111124","https://openalex.org/W2271587609","https://openalex.org/W2331601684","https://openalex.org/W2408371555","https://openalex.org/W2409825834","https://openalex.org/W2414024148","https://openalex.org/W2475979952","https://openalex.org/W2913076392","https://openalex.org/W4399043096","https://openalex.org/W6694234597","https://openalex.org/W6714431044","https://openalex.org/W6848544110","https://openalex.org/W6849273775","https://openalex.org/W6996279013"],"related_works":["https://openalex.org/W2011169857","https://openalex.org/W2018059421","https://openalex.org/W2412965647","https://openalex.org/W2110580832","https://openalex.org/W74854850","https://openalex.org/W948922129","https://openalex.org/W2014588531","https://openalex.org/W1914417617","https://openalex.org/W2414385781","https://openalex.org/W2013088288"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
