{"id":"https://openalex.org/W1971192121","doi":"https://doi.org/10.1086/424573","title":"Natural Course of Severe Acute Respiratory Syndrome\u2013Associated Coronavirus Immunoglobulin after Infection","display_name":"Natural Course of Severe Acute Respiratory Syndrome\u2013Associated Coronavirus Immunoglobulin after Infection","publication_year":2004,"publication_date":"2004-10-08","ids":{"openalex":"https://openalex.org/W1971192121","doi":"https://doi.org/10.1086/424573","mag":"1971192121","pmid":"https://pubmed.ncbi.nlm.nih.gov/15478079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7109779"},"language":"en","primary_location":{"id":"doi:10.1086/424573","doi":"https://doi.org/10.1086/424573","is_oa":true,"landing_page_url":"https://doi.org/10.1086/424573","pdf_url":"https://academic.oup.com/jid/article-pdf/190/9/1706/2619934/190-9-1706.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jid/article-pdf/190/9/1706/2619934/190-9-1706.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075410190","display_name":"Eugene Y. K. Tso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene\u00a0Y.\u00a0K. Tso","raw_affiliation_strings":["Department of Medicine and Geriatrics, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Geriatrics, Hong Kong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112735757","display_name":"O. T. Y. Tsang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Owen\u00a0T.\u00a0Y. Tsang","raw_affiliation_strings":["Department of Medicine and Geriatrics, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Geriatrics, Hong Kong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059231992","display_name":"Bosco Hoi Shiu Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131216","display_name":"Princess Margaret Hospital","ror":"https://ror.org/03jrxta72","country_code":"HK","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210131216"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Bosco Lam","raw_affiliation_strings":["Department of Pathology, Princess Margaret Hospital, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Princess Margaret Hospital, Hong Kong, China","institution_ids":["https://openalex.org/I4210131216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111883353","display_name":"T. K. Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131216","display_name":"Princess Margaret Hospital","ror":"https://ror.org/03jrxta72","country_code":"HK","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210131216"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"T.\u00a0K. Ng","raw_affiliation_strings":["Department of Pathology, Princess Margaret Hospital, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Princess Margaret Hospital, Hong Kong, China","institution_ids":["https://openalex.org/I4210131216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110300735","display_name":"Wilina Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325714086","display_name":"Department of Health","ror":"https://ror.org/030jqbn26","country_code":"CN","type":"government","lineage":["https://openalex.org/I1325714086","https://openalex.org/I2800501823"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wilina Lim","raw_affiliation_strings":["Government Virus Unit, Department of Health, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Virus Unit, Department of Health, Hong Kong, China","institution_ids":["https://openalex.org/I1325714086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111699626","display_name":"Thomas S. T. Lai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas\u00a0S.\u00a0T. Lai","raw_affiliation_strings":["Department of Medicine and Geriatrics, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Geriatrics, Hong Kong, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"190","issue":"9","first_page":"1706","last_page":"1707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars","display_name":"SARS","score":0.6039999723434448},{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.9229999780654907},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.6510000228881836},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.6039999723434448},{"id":"https://openalex.org/keywords/antibody-persistence","display_name":"antibody persistence","score":0.7480000257492065},{"id":"https://openalex.org/keywords/sars-survivors","display_name":"SARS survivors","score":0.7229999899864197},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.47600001096725464},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7170000076293945},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/hong-kong-sars-outbreak","display_name":"Hong Kong SARS outbreak","score":0.5870000123977661},{"id":"https://openalex.org/keywords/sars-epidemic","display_name":"SARS epidemic","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6343926787376404},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.608268678188324},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5394149422645569},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5363660454750061},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5056734085083008},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4730628728866577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4628220498561859},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.440321683883667},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.43212729692459106},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.13878130912780762},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.10353842377662659},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10163149237632751},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06564408540725708}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045169","descriptor_name":"Severe Acute Respiratory Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045473","descriptor_name":"Severe acute respiratory syndrome-related coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1086/424573","doi":"https://doi.org/10.1086/424573","is_oa":true,"landing_page_url":"https://doi.org/10.1086/424573","pdf_url":"https://academic.oup.com/jid/article-pdf/190/9/1706/2619934/190-9-1706.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6068118","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7109779","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7109779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7109779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmid:15478079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15478079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1086/424573","doi":"https://doi.org/10.1086/424573","is_oa":true,"landing_page_url":"https://doi.org/10.1086/424573","pdf_url":"https://academic.oup.com/jid/article-pdf/190/9/1706/2619934/190-9-1706.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971192121.pdf","grobid_xml":"https://content.openalex.org/works/W1971192121.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1975490802","https://openalex.org/W2037764012","https://openalex.org/W2091889947","https://openalex.org/W2112807730","https://openalex.org/W2114421929","https://openalex.org/W2133684931","https://openalex.org/W2143245040","https://openalex.org/W2157976373","https://openalex.org/W2158607167","https://openalex.org/W2159771354"],"related_works":["https://openalex.org/W7096349712","https://openalex.org/W2141787825","https://openalex.org/W3008884953","https://openalex.org/W2356360877","https://openalex.org/W2125976019","https://openalex.org/W2005719271","https://openalex.org/W2156368174","https://openalex.org/W2363273672","https://openalex.org/W4225483617","https://openalex.org/W2061311775"],"abstract_inverted_index":{"To":[0],"the":[1,52,67,95,125,131,151,202,303,315,320,337,346,357,365,381,385,401,405,423,437,453,459,466,471,488,495,562,566,604,697,700,716,720,724,732,746],"Editor\u2014In":[2],"Chen":[3],"et":[4],"al.'s":[5],"recent":[6],"study,":[7,309,704],"severe":[8],"acute":[9,735],"respiratory":[10,736],"syndrome":[11],"(SARS)-associated":[12],"coronavirus":[13,738],"(SARSCoV)":[14],"IgG":[15],"was":[16,199,213,350,360,391,429,492,504,537],"shown":[17,575,585],"to":[18,23,59,93,268,319,364,413,431,494,510,555,576,625,667],"be":[19,626,709,731],"persistent":[20,77],"for":[21,173,207],"up":[22],"60":[24],"days":[25,379],"[1].":[26],"Their":[27],"results":[28,262],"suggested":[29],"that":[30,586,684],"production":[31],"of":[32,73,98,106,124,150,158,186,192,221,231,277,280,302,305,317,339,345,348,368,383,403,439,455,468,570,588,678,686,691,699,702,718,726,748,754],"this":[33],"antibody":[34,78,549,564],"is":[35,85,682],"dependent":[36],"on":[37,314],"CD4+":[38],"cells":[39,168],"and":[40,61,79,108,147,201,257,285,298,322,333,356,397,415,484,514,527,603,675,765],"might":[41],"play":[42],"a":[43,89,139,170,232,236,252,371,419,442,578,591,654],"role":[44],"in":[45,103,109,117,169,307,422,446,523,595,609,618,635,641,656,672,751,766],"protective":[46,657],"immunity":[47,81,658],"against":[48,82,550,565,659],"SARS":[49,74,83,99,107,163,306,340,349,373,387,407,425,496,500,533,571,589,596,619,629,642,660,671,687,692,727,755],"CoV.":[50,661],"On":[51,362,696],"other":[53,551,676],"hand,":[54],"IgM":[55],"has":[56,543,573,664],"been":[57,574,665],"found":[58],"decrease":[60,421,445,522,594,617,640,655],"become":[62],"undetectable":[63,557],"11":[64],"weeks":[65],"into":[66],"recovery":[68],"phase":[69],"[2].":[70],"Whether":[71],"survivors":[72,105,304,347,587,685,753],"can":[75,553],"have":[76,577,584,688],"lifelong":[80],"CoV":[84,100,374,388,408,426,501,534,572,597,620,630,643,693,728,741],"unknown.":[86],"We":[87],"conducted":[88],"1-year":[90],"prospective":[91],"study":[92,542,611],"investigate":[94],"natural":[96],"course":[97,747],"immunoglobulin":[101,195,375,389,409,427,502,535,598,621,631,644,694,729,739],"titer":[102,376,390,410,428,448,461,503,536,599,645],"62":[104,752],"1":[110,325,396,749,767],"asymptomatic":[111,472,605,768],"infected":[112,473,606,636,650,769],"health-care":[113,474,607,770],"worker,":[114,475],"as":[115,288],"described":[116],"our":[118,308,610,703],"previous":[119,541],"reports":[120],"[3,":[121],"4].":[122],"All":[123],"serologic":[126],"tests":[127,259],"were":[128,144,154,180,204,226,247,263,273,286,312,478],"performed":[129],"at":[130,176,210,395,433,449,462,512,722],"Government":[132],"Virus":[133],"Unit,":[134],"Hong":[135,673],"Kong,":[136],"China,":[137,679],"following":[138],"standard":[140],"protocol.":[141],"Serum":[142],"samples":[143,153,282,311,477],"diluted":[145,152],"1:25,":[146],"15":[148,323],"mL":[149],"incubated":[155,205],"by":[156,215,229,249,275],"use":[157,230,276],"microscopic":[159],"slides":[160,179,203,225],"coated":[161],"with":[162,183,197,218,260,265,458,670,760],"CoV-infected":[164],"fetal":[165],"rhesus":[166],"kidney":[167],"moist":[171],"chamber":[172],"30":[174,208],"min":[175,209],"37\u00b0.":[177],"The":[178,224,342,638],"then":[181,227],"washed":[182],"2":[184,219],"changes":[185,220],"Tween":[187,222],"20":[188],"(Sigma).":[189],"Fifteen":[190,378],"microliters":[191],"polyvalent":[193],"anti-human":[194],"labeled":[196],"fluorochrome":[198],"added,":[200],"again":[206],"37\u00b0C.":[211],"This":[212],"followed":[214],"another":[216],"wash":[217],"20.":[223],"examined":[228],"fluorescence":[233,246],"microscope,":[234],"under":[235,251],"low-power":[237],"field":[238,254],"(20":[239],"\u00d7).":[240],"Any":[241],"positive":[242],"signals":[243],"showing":[244],"cytoplasmic":[245],"confirmed":[248],"examination":[250],"high-power":[253],"(40":[255],"\u00d7),":[256],"all":[258,301,367],"indeterminate":[261],"repeated":[264],"uninfected":[266],"cells,":[267],"exclude":[269],"nonspecific":[270],"reactions.":[271],"Results":[272],"quantified":[274],"serial":[278],"titrations":[279],"serum":[281,310,476,663,706],"from":[283,711],"patients":[284,669],"reported":[287,544],"titers":[289,759],"(<25,":[290],"25,":[291],"50,":[292],"100,":[293],"200,":[294],"400,":[295],"800,":[296],"1600,":[297],"3200).":[299],"For":[300,470],"collected":[313,479,710],"day":[316,490],"admission":[318,363],"hospital":[321],"days,":[324],"month,":[326],"3":[327,398,463,513],"months,":[328,330,332,602],"6":[329,515],"9":[331,526,601],"12":[334,434,450,485,528],"months":[335,399,435,451,464,486,516,529,714],"after":[336,380,400,436,452,465,487,517,530,715],"onset":[338,382,402,438,454,467,717],"symptoms.":[341],"mean":[343,386,406,424,447,460,758],"age":[344],"37.07":[351],"years":[352],"(SD,":[353],"12.96":[354],"years),":[355],"male:female":[358],"ratio":[359],"0.82.":[361],"hospital,":[366],"them":[369],"had":[370,411],"baseline":[372],"!25.":[377],"symptoms,":[384,404,456,719],"252.8":[392],"(figure":[393,506],"1A);":[394],"increased":[412],"613.3":[414],"880.3,":[416],"respectively.":[417],"Afterward,":[418],"gradual":[420],"observed,":[430],"167.7":[432],"symptoms":[440],"(i.e.,":[441,519],"5.3-":[443],"fold":[444],"compared":[457],"symptoms).":[469],"1,":[480],"3,":[481],"6,":[482],"9,":[483],"first":[489,499],"she":[491],"deployed":[493],"ward.":[497],"Her":[498],"400":[505],"1B),":[507],"which":[508,723],"decreased":[509],"50":[511],"deployment":[518],"an":[520,556,613],"8-fold":[521],"titer).":[524],"At":[525],"deployment,":[531],"her":[532],"only":[538],"25.":[539],"A":[540],"that,":[545,647],"over":[546,600,648,745],"time,":[547,649],"neutralizing":[548,579],"CoVs":[552],"decay":[554],"level":[558],"[5].":[559],"In":[560],"SARS,":[561],"human":[563],"S1":[567],"spike":[568],"protein":[569],"effect":[580],"[6].":[581],"Our":[582],"findings":[583,701],"experience":[590,653],"minimum":[592],"5-fold":[593],"worker":[608,771],"experienced":[612],"even":[614],"more":[615],"rapid":[616],"titer.":[622],"It":[623],"remains":[624],"seen":[627],"whether":[628],"will":[632],"finally":[633],"disappear":[634],"persons.":[637],"progressive":[639],"implies":[646],"persons":[651],"may":[652],"Convalescent":[662],"used":[666],"treat":[668],"Kong":[674],"parts":[677],"because":[680],"it":[681],"expected":[683],"high":[689],"levels":[690],"[7].":[695],"basis":[698],"convalescent":[705],"ideally":[707],"should":[708],"donors":[712],"\u2a7d3":[713],"time":[721],"yield":[725],"would":[730],"highest.":[733],"Severe":[734],"syndrome\u2014associated":[737],"(SARS":[740],"Ig)":[742],"titers,":[743],"measured":[744],"year":[750],"(shown":[756],"are":[757],"95%":[761],"confidence":[762],"intervals)":[763],"(A)":[764],"(B).":[772]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}