{"id":"https://openalex.org/W1971190449","doi":"https://doi.org/10.1016/0165-1781(83)90042-2","title":"Brain purinergic activity linked with depressive symptomatology: Hypoxanthine and xanthine in CSF of patients with major depressive disorders","display_name":"Brain purinergic activity linked with depressive symptomatology: Hypoxanthine and xanthine in CSF of patients with major depressive disorders","publication_year":1983,"publication_date":"1983-07-01","ids":{"openalex":"https://openalex.org/W1971190449","doi":"https://doi.org/10.1016/0165-1781(83)90042-2","mag":"1971190449","pmid":"https://pubmed.ncbi.nlm.nih.gov/6578531"},"language":"en","primary_location":{"id":"doi:10.1016/0165-1781(83)90042-2","doi":"https://doi.org/10.1016/0165-1781(83)90042-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1781(83)90042-2","pdf_url":null,"source":{"id":"https://openalex.org/S84074229","display_name":"Psychiatry Research","issn_l":"0165-1781","issn":["0165-1781","1872-7123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hans \u00c5gren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Hans \u00c5gren","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital, S-751 85 Uppsala, Sweden","Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden","Hans \u00c5gren, M.D., is in the Department of Psychiatry, University Hospital, S-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Hans \u00c5gren, M.D., is in the Department of Psychiatry, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110081395","display_name":"Frank Niklasson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Frank Niklasson","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital, S-751 85 Uppsala, Sweden","Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden","Hans \u00c5gren, M.D., is in the Department of Psychiatry, University Hospital, S-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Hans \u00c5gren, M.D., is in the Department of Psychiatry, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111611735","display_name":"Roger H\u00e4llgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Roger H\u00e4llgren","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital, S-751 85 Uppsala, Sweden","Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden","Hans \u00c5gren, M.D., is in the Department of Psychiatry, University Hospital, S-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]},{"raw_affiliation_string":"Hans \u00c5gren, M.D., is in the Department of Psychiatry, University Hospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1342360035"],"apc_list":{"value":4230,"currency":"USD","value_usd":4230},"apc_paid":null,"fwci":0.6818,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.6547619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"179","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/xanthine","display_name":"xanthine","score":1.0},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9070000052452087},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.8180000185966492},{"id":"https://openalex.org/keywords/anger","display_name":"anger","score":0.5329999923706055},{"id":"https://openalex.org/keywords/suicidality","display_name":"suicidality","score":0.753000020980835},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.9890000224113464},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.9210368990898132},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.888805627822876},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6494705080986023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6315072774887085},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5942967534065247},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5150449275970459},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5126637816429138},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46372124552726746},{"id":"https://openalex.org/C2779302386","wikidata":"https://www.wikidata.org/wiki/Q79871","display_name":"Anger","level":2,"score":0.46213996410369873},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.4605270028114319},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4168068468570709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36754316091537476},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.35507139563560486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18230140209197998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1636168360710144},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000341","descriptor_name":"Affective Disorders, Psychotic","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007042","descriptor_name":"Hypoxanthines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-1781(83)90042-2","doi":"https://doi.org/10.1016/0165-1781(83)90042-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1781(83)90042-2","pdf_url":null,"source":{"id":"https://openalex.org/S84074229","display_name":"Psychiatry Research","issn_l":"0165-1781","issn":["0165-1781","1872-7123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry Research","raw_type":"journal-article"},{"id":"pmid:6578531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6578531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W26453693","https://openalex.org/W657436150","https://openalex.org/W1272719990","https://openalex.org/W1784545427","https://openalex.org/W1972156069","https://openalex.org/W1984646527","https://openalex.org/W1987025877","https://openalex.org/W1989514730","https://openalex.org/W1994458505","https://openalex.org/W2006851386","https://openalex.org/W2019080766","https://openalex.org/W2020425342","https://openalex.org/W2022480405","https://openalex.org/W2034562813","https://openalex.org/W2049165791","https://openalex.org/W2056365461","https://openalex.org/W2061541290","https://openalex.org/W2075056521","https://openalex.org/W2083069545","https://openalex.org/W2086391260","https://openalex.org/W2093949644","https://openalex.org/W2104749218","https://openalex.org/W2130694858","https://openalex.org/W2154628287","https://openalex.org/W2158747611","https://openalex.org/W2165213106","https://openalex.org/W2283525886","https://openalex.org/W2325503991","https://openalex.org/W2334718870","https://openalex.org/W2408930712","https://openalex.org/W2415273132","https://openalex.org/W2471526013","https://openalex.org/W2798643531","https://openalex.org/W3027485947","https://openalex.org/W4406985551"],"related_works":["https://openalex.org/W2104749218","https://openalex.org/W2343114247","https://openalex.org/W2025212739","https://openalex.org/W2473161759","https://openalex.org/W2011495427","https://openalex.org/W2036602098","https://openalex.org/W7100915641","https://openalex.org/W2443282322","https://openalex.org/W2348952454","https://openalex.org/W1981117387"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
