{"id":"https://openalex.org/W1971185151","doi":"https://doi.org/10.1371/journal.pone.0007643","title":"PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population","display_name":"PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population","publication_year":2009,"publication_date":"2009-10-27","ids":{"openalex":"https://openalex.org/W1971185151","doi":"https://doi.org/10.1371/journal.pone.0007643","mag":"1971185151","pmid":"https://pubmed.ncbi.nlm.nih.gov/19862325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2763267"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0007643","doi":"https://doi.org/10.1371/journal.pone.0007643","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007643","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007643&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007643&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061706594","display_name":"Cheng Hu","orcid":"https://orcid.org/0000-0003-4314-2386","observed_orcids":["https://orcid.org/0000-0003-4314-2386"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Hu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101912575","display_name":"Rong Zhang","orcid":"https://orcid.org/0000-0002-0003-2200","observed_orcids":["https://orcid.org/0000-0002-0003-2200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Zhang","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077396511","display_name":"Congrong Wang","orcid":"https://orcid.org/0000-0002-8645-1114","observed_orcids":["https://orcid.org/0000-0002-8645-1114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Congrong Wang","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440024","display_name":"Jie Wang","orcid":"https://orcid.org/0000-0001-8933-9737","observed_orcids":["https://orcid.org/0000-0001-8933-9737"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","Shanghai Clinical Center for Diabetes, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103546536","display_name":"Xiaojing Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaojing Ma","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061760629","display_name":"Jingyi Lu","orcid":"https://orcid.org/0000-0003-1105-4189","observed_orcids":["https://orcid.org/0000-0003-1105-4189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingyi Lu","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073064782","display_name":"Wen Qin","orcid":"https://orcid.org/0000-0002-9121-8296","observed_orcids":["https://orcid.org/0000-0002-9121-8296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Qin","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027325688","display_name":"Xuhong Hou","orcid":"https://orcid.org/0000-0001-6156-5994","observed_orcids":["https://orcid.org/0000-0001-6156-5994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuhong Hou","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111831050","display_name":"Chen Wang","orcid":"https://orcid.org/0000-0003-3912-5321","observed_orcids":["https://orcid.org/0000-0003-3912-5321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709162","display_name":"Yuqian Bao","orcid":"https://orcid.org/0000-0002-4754-3470","observed_orcids":["https://orcid.org/0000-0002-4754-3470"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqian Bao","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","Shanghai Clinical Center for Diabetes, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105367140","display_name":"Kun\u2010san Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunsan Xiang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007251193","display_name":"Weiping Jia","orcid":"https://orcid.org/0000-0002-6244-2168","observed_orcids":["https://orcid.org/0000-0002-6244-2168"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weiping Jia","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","Shanghai Clinical Center for Diabetes, Shanghai, China","Shanghai Diabetes Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Shanghai Clinical Center for Diabetes, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Diabetes Institute, Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007251193"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":6.8269,"has_fulltext":true,"cited_by_count":180,"citation_normalized_percentile":{"value":0.97705352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"4","issue":"10","first_page":"e7643","last_page":"e7643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.8130000233650208},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kcnj11","display_name":"KCNJ11","score":1.0},{"id":"https://openalex.org/keywords/cdkal1","display_name":"CDKAL1","score":1.0},{"id":"https://openalex.org/keywords/cdkn2a-cdkn2b","display_name":"CDKN2A/CDKN2B","score":0.9900000095367432},{"id":"https://openalex.org/keywords/igf2bp2","display_name":"IGF2BP2","score":1.0},{"id":"https://openalex.org/keywords/slc30a8","display_name":"SLC30A8","score":1.0},{"id":"https://openalex.org/keywords/thada","display_name":"THADA","score":0.7210000157356262},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5440000295639038},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7770810127258301},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6664626598358154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5412340760231018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4610544741153717},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43828338384628296},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4340152144432068},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.36908942461013794},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.34936103224754333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25776544213294983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2522282600402832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0586169958114624},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075703","descriptor_name":"Zinc Transporter 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099161","descriptor_name":"Kcnj11 Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007339","descriptor_name":"Insulysin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0007643","doi":"https://doi.org/10.1371/journal.pone.0007643","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007643","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007643&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2763267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2763267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19862325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19862325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.3141","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.3141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/90/86/pone.0007643.PMC2763267.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3017fab58bc14ba4a8a76d9c602a1cc1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3017fab58bc14ba4a8a76d9c602a1cc1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 10, p e7643 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0007643","doi":"https://doi.org/10.1371/journal.pone.0007643","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007643","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007643&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4243412236","display_name":null,"funder_award_id":"863 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6955277572","display_name":"\u4e2d\u56fd\u4eba2\u578b\u7cd6\u5c3f\u75c5\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\u4e2d\u53d1\u73b0\u6613\u611f\u4f4d\u70b9\u7684\u5927\u6837\u672c\u5173\u8054\u7814\u7a76","funder_award_id":"30800617","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320320870","display_name":"European Foundation for the Study of Diabetes","ror":"https://ror.org/05tgz4m05"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320327803","display_name":"Shanghai Rising-Star Program","ror":null},{"id":"https://openalex.org/F4320335305","display_name":"School of Medicine, Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971185151.pdf","grobid_xml":"https://content.openalex.org/works/W1971185151.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1944558458","https://openalex.org/W1971751459","https://openalex.org/W1978215768","https://openalex.org/W2002900423","https://openalex.org/W2025143098","https://openalex.org/W2029814786","https://openalex.org/W2048755332","https://openalex.org/W2052838381","https://openalex.org/W2057899710","https://openalex.org/W2060270800","https://openalex.org/W2082122713","https://openalex.org/W2094265977","https://openalex.org/W2097660065","https://openalex.org/W2100445405","https://openalex.org/W2112027875","https://openalex.org/W2122355663","https://openalex.org/W2122895430","https://openalex.org/W2126700037","https://openalex.org/W2133972493","https://openalex.org/W2134293572","https://openalex.org/W2135349969","https://openalex.org/W2142948935","https://openalex.org/W2153646897","https://openalex.org/W2159656713","https://openalex.org/W2160234571","https://openalex.org/W2161633633"],"related_works":["https://openalex.org/W7096611253","https://openalex.org/W2136681918","https://openalex.org/W1505594724","https://openalex.org/W7097630322","https://openalex.org/W2028866748","https://openalex.org/W6958240865","https://openalex.org/W2163025893","https://openalex.org/W2203298633","https://openalex.org/W2078839691","https://openalex.org/W2130662434"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"advance":[2],"in":[3,58,205],"genetic":[4],"studies":[5],"added":[6],"the":[7,24,74,80,90,94,131,139,146,202,206,241,257,280,303],"confirmed":[8,145,279],"susceptible":[9,95],"loci":[10,33,54,96,239,300],"for":[11,161,252],"type":[12,35,62,98,107,162,197,253,258,292,296],"2":[13,36,63,99,108,163,198,254,259,293,297],"diabetes":[14,37,64,100,109,260,298],"to":[15,22,42,171,178,267,302],"eighteen.":[16],"In":[17],"this":[18],"study,":[19],"we":[20],"attempt":[21],"analyze":[23],"independent":[25],"and":[26,38,65,76,82,106,119,157,196,289,291],"joint":[27,91,232],"effect":[28,233],"of":[29,84,93,130,148,235],"variants":[30],"from":[31,52,150,169,176,188,237],"these":[32,85],"on":[34,97,159,201],"clinical":[39],"phenotypes":[40],"related":[41],"glucose":[43,70,221],"metabolism.":[44],"METHODS/PRINCIPAL":[45],"FINDINGS:":[46],"Twenty-one":[47],"single":[48],"nucleotide":[49],"polymorphisms":[50],"(SNPs)":[51],"fourteen":[53],"were":[55,110,122],"successfully":[56],"genotyped":[57],"1,849":[59],"subjects":[60,67,208],"with":[61,68,165,216,262],"1,785":[66],"normal":[69],"regulation.":[71],"We":[72,144],"analyzed":[73],"allele":[75,265],"genotype":[77],"distribution":[78],"between":[79,104,117,186,282],"cases":[81],"controls":[83],"SNPs":[86,105,118,149,187,236],"as":[87,89],"well":[88],"effects":[92,147],"risk.":[101],"The":[102,115,127,231,276],"associations":[103,116],"examined":[111,123],"by":[112,124,136],"logistic":[113],"regression.":[114,126],"quantitative":[120,203],"traits":[121,204],"linear":[125],"discriminative":[128],"accuracy":[129],"prediction":[132],"models":[133],"was":[134,184,214],"assessed":[135],"area":[137],"under":[138],"receiver":[140],"operating":[141],"characteristic":[142],"curves.":[143],"PPARG,":[151,283],"KCNJ11,":[152,284],"CDKAL1,":[153,285],"CDKN2A-CDKN2B,":[154,286],"IDE-KIF11-HHEX,":[155,287],"IGF2BP2":[156,288],"SLC30A8":[158,290],"risk":[160,245,251,264,299],"diabetes,":[164],"odds":[166],"ratios":[167],"ranging":[168],"1.114":[170],"1.406":[172],"(P":[173,224,272],"value":[174],"range":[175],"0.0335":[177],"1.37E-12).":[179],"But":[180],"no":[181],"significant":[182],"association":[183,215,281],"detected":[185],"WFS1,":[189],"FTO,":[190],"JAZF1,":[191],"TSPAN8-LGR5,":[192],"THADA,":[193],"ADAMTS9,":[194],"NOTCH2-ADAM30":[195],"diabetes.":[199,255,294],"Analyses":[200],"control":[207],"showed":[209,240],"that":[210],"THADA":[211],"SNP":[212],"rs7578597":[213],"2-h":[217],"insulin":[218],"during":[219],"oral":[220],"tolerance":[222],"tests":[223],"=":[225,229,273],"0.0005,":[226],"empirical":[227],"P":[228],"0.0090).":[230],"analysis":[234],"eleven":[238],"individual":[242],"carrying":[243],"more":[244,263],"alleles":[246],"had":[247],"a":[248],"significantly":[249],"higher":[250],"And":[256],"patients":[261],"tended":[266],"have":[268],"earlier":[269],"diagnostic":[270],"ages":[271],"0.0006).":[274],"CONCLUSIONS/SIGNIFICANCE:":[275],"current":[277],"study":[278],"These":[295],"contributed":[301],"disease":[304],"additively.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
