{"id":"https://openalex.org/W1971165751","doi":"https://doi.org/10.1002/ijc.27924","title":"Cancer cells preferentially lose small chromosomes","display_name":"Cancer cells preferentially lose small chromosomes","publication_year":2012,"publication_date":"2012-11-05","ids":{"openalex":"https://openalex.org/W1971165751","doi":"https://doi.org/10.1002/ijc.27924","mag":"1971165751","pmid":"https://pubmed.ncbi.nlm.nih.gov/23124507","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3587043"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.27924","doi":"https://doi.org/10.1002/ijc.27924","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.27924","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3587043","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067735700","display_name":"Pascal H. G. Duijf","orcid":"https://orcid.org/0000-0001-8646-9843","observed_orcids":["https://orcid.org/0000-0001-8646-9843"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2801814493","display_name":"Princess Alexandra Hospital","ror":"https://ror.org/04mqb0968","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I2801814493","https://openalex.org/I4210089726"]}],"countries":["AU","US"],"is_corresponding":true,"raw_author_name":"Pascal H.G. Duijf","raw_affiliation_strings":["Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. duijf@uq.edu.au","Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY","Tel.: +1-646-888-2814,","The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. duijf@uq.edu.au","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Tel.: +1-646-888-2814,","institution_ids":[]},{"raw_affiliation_string":"The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2801814493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033125884","display_name":"Nikolaus D. Schultz","orcid":"https://orcid.org/0000-0002-0131-4904","observed_orcids":["https://orcid.org/0000-0002-0131-4904"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolaus Schultz","raw_affiliation_strings":["Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076784996","display_name":"Robert Benezra","orcid":"https://orcid.org/0000-0002-6031-6870","observed_orcids":["https://orcid.org/0000-0002-6031-6870"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Benezra","raw_affiliation_strings":["Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY","Tel.: +1-646-888-2812,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Tel.: +1-646-888-2812,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067735700","https://openalex.org/A5076784996"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I165143802","https://openalex.org/I2801814493"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":3.835,"has_fulltext":false,"cited_by_count":170,"citation_normalized_percentile":{"value":0.93909256,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"132","issue":"10","first_page":"2316","last_page":"2326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.155799999833107,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-chromosome-aneuploidy","display_name":"whole-chromosome aneuploidy","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chromosome-loss","display_name":"chromosome loss","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chromosomal-gains","display_name":"chromosomal gains","score":0.6909999847412109},{"id":"https://openalex.org/keywords/small-chromosomes","display_name":"small chromosomes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.6000000238418579},{"id":"https://openalex.org/keywords/oncogene-amplification","display_name":"oncogene amplification","score":0.8339999914169312},{"id":"https://openalex.org/keywords/proteotoxic-stress","display_name":"proteotoxic stress","score":0.7390000224113464},{"id":"https://openalex.org/keywords/trisomy","display_name":"trisomy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ovarian-adenocarcinoma","display_name":"ovarian adenocarcinoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.8267604112625122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7667945623397827},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.6544680595397949},{"id":"https://openalex.org/C99983632","wikidata":"https://www.wikidata.org/wiki/Q1087765","display_name":"Chromothripsis","level":5,"score":0.5663279891014099},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5364060997962952},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5234484076499939},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.505734920501709},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.503407895565033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4949039816856384},{"id":"https://openalex.org/C109748351","wikidata":"https://www.wikidata.org/wiki/Q657319","display_name":"Chromosome 7 (human)","level":4,"score":0.4299900531768799},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.31620678305625916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20560631155967712},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018284","descriptor_name":"Cystadenocarcinoma, Serous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059785","descriptor_name":"Karyotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/ijc.27924","doi":"https://doi.org/10.1002/ijc.27924","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.27924","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:23124507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23124507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2995586","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3587043","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3587043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3587043","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2995586","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3587043","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3478406037","display_name":"MSKCC Center for Translational Cancer Genomic Analysis","funder_award_id":"U24CA143840","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1512828086","https://openalex.org/W1577353247","https://openalex.org/W1865665413","https://openalex.org/W1935136844","https://openalex.org/W1965707365","https://openalex.org/W1966300797","https://openalex.org/W1967684815","https://openalex.org/W1969525391","https://openalex.org/W1972215237","https://openalex.org/W1977255988","https://openalex.org/W1984328656","https://openalex.org/W1987084496","https://openalex.org/W1987369248","https://openalex.org/W1989031533","https://openalex.org/W2002246796","https://openalex.org/W2002647715","https://openalex.org/W2004825745","https://openalex.org/W2006141070","https://openalex.org/W2021579554","https://openalex.org/W2022527641","https://openalex.org/W2025183726","https://openalex.org/W2025782007","https://openalex.org/W2026652301","https://openalex.org/W2030202463","https://openalex.org/W2037404897","https://openalex.org/W2052908684","https://openalex.org/W2058131725","https://openalex.org/W2060084956","https://openalex.org/W2062214822","https://openalex.org/W2066455674","https://openalex.org/W2074548008","https://openalex.org/W2076452392","https://openalex.org/W2083048426","https://openalex.org/W2095479840","https://openalex.org/W2095617425","https://openalex.org/W2102922697","https://openalex.org/W2106666648","https://openalex.org/W2110522164","https://openalex.org/W2113754963","https://openalex.org/W2117567628","https://openalex.org/W2117692326","https://openalex.org/W2128016314","https://openalex.org/W2132075910","https://openalex.org/W2139940259","https://openalex.org/W2153056550","https://openalex.org/W2153467137","https://openalex.org/W2157780299","https://openalex.org/W2163176957","https://openalex.org/W2518697824","https://openalex.org/W3139886259","https://openalex.org/W4298324324"],"related_works":["https://openalex.org/W7217186235","https://openalex.org/W2101630824","https://openalex.org/W4317214250","https://openalex.org/W3192839809","https://openalex.org/W2015364653","https://openalex.org/W1970326565","https://openalex.org/W2771244525","https://openalex.org/W2418877789","https://openalex.org/W1965707365","https://openalex.org/W2080911310"],"abstract_inverted_index":{"Genetic":[0],"and":[1,15,27,35,50,75,189,214,230,238,242],"genomic":[2,38],"aberrations":[3],"are":[4,57,65,88,175],"the":[5,78,127,138,228],"primary":[6],"cause":[7],"of":[8,31,54,107,110,129,173,217,225,232],"cancer.":[9],"Chromosome":[10],"missegregation":[11],"leads":[12],"to":[13,22,118,126],"aneuploidy":[14,45,196,234],"provides":[16],"cancer":[17],"cells":[18],"with":[19,71,81,103],"a":[20,123,148,155,167,176],"mechanism":[21],"lose":[23],"tumor":[24,163],"suppressor":[25],"loci":[26],"gain":[28],"extra":[29,130,139],"copies":[30,132],"oncogenes.":[32],"Using":[33],"cytogenetic":[34],"array-based":[36],"comparative":[37],"hybridization":[39],"data,":[40],"we":[41,135,185],"analyzed":[42],"numerical":[43],"chromosome":[44,104,113,140,170,207],"in":[46,122,141,180,211,235,246],"43,205":[47],"human":[48,236],"tumors":[49,56,143,237],"found":[51],"that":[52,137,154,187],"68%":[53],"solid":[55,60,188],"aneuploid.":[58],"In":[59,183],"tumors,":[61],"almost":[62],"all":[63],"chromosomes":[64,72,87,174],"more":[66,82,90],"frequently":[67],"lost":[68,89],"than":[69,92],"gained":[70],"7,":[73],"12":[74],"20":[76],"being":[77],"only":[79],"exceptions":[80],"frequent":[83],"gains.":[84,105],"Strikingly,":[85],"small":[86],"readily":[91],"large":[93],"ones,":[94],"but":[95],"no":[96],"such":[97],"inverse":[98],"size":[99],"correlation":[100],"is":[101,159,209],"observed":[102,210],"Because":[106],"increasing":[108],"levels":[109],"proteotoxic":[111],"stress,":[112],"gains":[114,172],"have":[115,147,192],"been":[116],"shown":[117],"slow":[119],"cell":[120],"proliferation":[121,157],"manner":[124],"proportional":[125],"number":[128],"gene":[131,150],"gained.":[133],"However,":[134],"find":[136,186],"trisomic":[142],"does":[144],"not":[145,160],"preferentially":[146],"low":[149],"copy":[151],"number,":[152],"suggesting":[153],"proteotoxicity-mediated":[156],"barrier":[158],"sustained":[161],"during":[162],"progression.":[164],"Paradoxically,":[165],"despite":[166],"bias":[168],"toward":[169],"loss,":[171],"poor":[177],"prognostic":[178],"marker":[179],"ovarian":[181],"adenocarcinomas.":[182],"addition,":[184],"non-solid":[190],"cancers":[191],"markedly":[193],"distinct":[194],"whole-chromosome":[195,233],"signatures,":[197],"which":[198],"may":[199],"underlie":[200],"their":[201],"fundamentally":[202],"different":[203],"etiologies.":[204],"Finally,":[205],"preferential":[206],"loss":[208],"both":[212],"early":[213],"late":[215],"stages":[216],"astrocytoma.":[218],"Our":[219],"results":[220],"open":[221],"up":[222],"new":[223],"avenues":[224],"enquiry":[226],"into":[227],"role":[229],"nature":[231],"will":[239],"redirect":[240],"modeling":[241],"genetic":[243],"targeting":[244],"efforts":[245],"patients.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
