{"id":"https://openalex.org/W1971031244","doi":"https://doi.org/10.1111/j.1748-1716.1974.tb05660.x","title":"Effects of Ethanol, tert. Butanol, and Clomethiazole on Net Movements of Sodium and Potassium in Electrically Stimulated Cerebral Tissue","display_name":"Effects of Ethanol, tert. Butanol, and Clomethiazole on Net Movements of Sodium and Potassium in Electrically Stimulated Cerebral Tissue","publication_year":1974,"publication_date":"1974-05-01","ids":{"openalex":"https://openalex.org/W1971031244","doi":"https://doi.org/10.1111/j.1748-1716.1974.tb05660.x","mag":"1971031244","pmid":"https://pubmed.ncbi.nlm.nih.gov/4835715"},"language":"en","primary_location":{"id":"doi:10.1111/j.1748-1716.1974.tb05660.x","doi":"https://doi.org/10.1111/j.1748-1716.1974.tb05660.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1748-1716.1974.tb05660.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210232992","display_name":"Acta Physiologica Scandinavica","issn_l":"0001-6772","issn":["0001-6772","1365-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082450953","display_name":"Henrik Wallgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"H. Wallgren","raw_affiliation_strings":["Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019472314","display_name":"P. Nikander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. Nikander","raw_affiliation_strings":["Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079417527","display_name":"P. von Boguslawsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. von Boguslawsky","raw_affiliation_strings":["Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047246126","display_name":"Jaakko Linkola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Linkola","raw_affiliation_strings":["Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories of the State Alcohol Monopoly (Alko), and Department of Physiological Zoology, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":null,"apc_paid":null,"fwci":1.133,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7213361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"91","issue":"1","first_page":"83","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.155799999833107,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tert-butyl-alcohol","display_name":"tert-butanol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clomethiazole","display_name":"chlormethiazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sodium-transport","display_name":"sodium transport","score":0.5889999866485596},{"id":"https://openalex.org/keywords/potassium-transport","display_name":"potassium transport","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cerebral-cortex-slices","display_name":"cerebral cortex slices","score":0.7789999842643738},{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sodium-channels","display_name":"sodium channels","score":0.7360000014305115},{"id":"https://openalex.org/keywords/potassium-binding-site","display_name":"potassium binding site","score":0.703000009059906},{"id":"https://openalex.org/keywords/ion-transport-inhibition","display_name":"ion transport inhibition","score":0.628000020980835},{"id":"https://openalex.org/keywords/sodium-leakage","display_name":"sodium leakage","score":0.3959999978542328},{"id":"https://openalex.org/keywords/potassium-accumulation","display_name":"potassium accumulation","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8562232255935669},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.7942843437194824},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.7103890180587769},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5489561557769775},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5394824743270874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35619425773620605},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3493794798851013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18259769678115845},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.056576699018478394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000440","descriptor_name":"Butanols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002719","descriptor_name":"Chlormethiazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1748-1716.1974.tb05660.x","doi":"https://doi.org/10.1111/j.1748-1716.1974.tb05660.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1748-1716.1974.tb05660.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210232992","display_name":"Acta Physiologica Scandinavica","issn_l":"0001-6772","issn":["0001-6772","1365-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:4835715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4835715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W69613843","https://openalex.org/W205755798","https://openalex.org/W1447117365","https://openalex.org/W1877873475","https://openalex.org/W1957749224","https://openalex.org/W1982535807","https://openalex.org/W1990728049","https://openalex.org/W1991882147","https://openalex.org/W1994408334","https://openalex.org/W1996651364","https://openalex.org/W2006090981","https://openalex.org/W2007233505","https://openalex.org/W2008778537","https://openalex.org/W2017183270","https://openalex.org/W2020285419","https://openalex.org/W2036466829","https://openalex.org/W2041655276","https://openalex.org/W2052269052","https://openalex.org/W2055830907","https://openalex.org/W2068546892","https://openalex.org/W2101732290","https://openalex.org/W2109963077","https://openalex.org/W2129426399","https://openalex.org/W2145861896","https://openalex.org/W2147207709","https://openalex.org/W2167957983","https://openalex.org/W2316870027","https://openalex.org/W2404426883","https://openalex.org/W2415940211"],"related_works":["https://openalex.org/W274026373","https://openalex.org/W1996651364","https://openalex.org/W1955420505","https://openalex.org/W2047268162","https://openalex.org/W1988332747","https://openalex.org/W1985090126","https://openalex.org/W4239417521","https://openalex.org/W2412035151","https://openalex.org/W2041187733","https://openalex.org/W2336668727"],"abstract_inverted_index":{"Abstract":[0],"The":[1,52,118],"sodium":[2,76,108,135,140,159],"and":[3,17,62,77,145],"potassium":[4,80,116,189],"contents":[5],"of":[6,25,38,54,75,79,91,99,107,126,133,139,151,158,172,185],"rat":[7],"brain":[8],"cortex":[9],"slices":[10],"incubated":[11],"in":[12,44,81,192],"bicarbonate":[13],"medium":[14,46],"were":[15,66],"measured":[16],"the":[18,23,26,35,69,82,89,92,105,127,130,134,142,149,152,170,188,193],"intracellular":[19],"quantities":[20],"estimated":[21],"on":[22,68,88,109,115,129,148],"basis":[24],"inulin":[27],"distribution.":[28],"Ethanol":[29],"(109":[30,56],"mM)":[31,61,65],"did":[32],"not":[33,167],"affect":[34],"ion":[36,194],"content":[37],"unstimulated":[39],"tissue":[40],"during":[41,141],"passive":[42],"leakage":[43],"cold":[45],"or":[47],"aerobic":[48],"incubation":[49],"at":[50],"37oC.":[51],"effects":[53],"ethanol":[55,186],"mM),":[57],"tert.":[58],"butanol":[59],"(34":[60],"clomethiazole":[63],"(0.39":[64],"tested":[67],"response":[70],"to":[71],"electrical":[72],"stimulation":[73,110],"(entry":[74],"loss":[78],"non\u2010inulin":[83],"space)":[84],"as":[85,87],"well":[86],"restoration":[90],"ionic":[93],"gradients":[94],"occurring":[95],"after":[96],"a":[97,182],"period":[98],"stimulation.":[100],"All":[101],"agents":[102],"selectively":[103],"inhibited":[104],"entry":[106],"with":[111,123,176],"very":[112],"little":[113],"effect":[114],"loss.":[117],"result":[119],"is":[120],"considered":[121],"compatible":[122],"preferential":[124],"action":[125],"drugs":[128],"activation":[131],"step":[132],"channel":[136],"controlling":[137],"movement":[138],"excitation":[143],"cycle,":[144],"presumably":[146],"located":[147],"outside":[150],"membranes.":[153],"During":[154],"recovery,":[155],"no":[156],"inhibition":[157],"expulsion":[160],"was":[161],"observed,":[162],"whereas":[163],"both":[164],"alcohols\u2010":[165],"but":[166],"clomethiazole\u2010slightly":[168],"decreased":[169],"accumulation":[171],"potassium.":[173],"Considered":[174],"together":[175],"other":[177],"observations,":[178],"this":[179],"finding":[180],"suggests":[181],"special":[183],"affinity":[184],"for":[187],"binding":[190],"site":[191],"transport":[195],"system.":[196]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
