{"id":"https://openalex.org/W1971024583","doi":"https://doi.org/10.3892/or.14.4.963","title":"Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event","display_name":"Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W1971024583","doi":"https://doi.org/10.3892/or.14.4.963","mag":"1971024583","pmid":"https://pubmed.ncbi.nlm.nih.gov/16142358"},"language":"en","primary_location":{"id":"doi:10.3892/or.14.4.963","doi":"https://doi.org/10.3892/or.14.4.963","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.14.4.963","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109546108","display_name":"Kue Peng Lim","orcid":"https://orcid.org/0000-0002-5670-8070","observed_orcids":["https://orcid.org/0000-0002-5670-8070"]},"institutions":[{"id":"https://openalex.org/I4210092640","display_name":"Cancer Research Malaysia","ror":"https://ror.org/00g0aq541","country_code":"MY","type":"nonprofit","lineage":["https://openalex.org/I4210092640","https://openalex.org/I4210147568"]},{"id":"https://openalex.org/I4210147568","display_name":"Subang Jaya Medical Centre","ror":"https://ror.org/05b01nv96","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I4210147568"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Kue Lim","raw_affiliation_strings":["Cancer Research Initiatives Foundation (CARIF), Outpatient Centre, Subang Jaya Medical Centre, 47500 Subang Jaya, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Initiatives Foundation (CARIF), Outpatient Centre, Subang Jaya Medical Centre, 47500 Subang Jaya, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210092640","https://openalex.org/I4210147568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111455104","display_name":"Sharifah Hamid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid Sharifah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109585118","display_name":"Shin Hin Lau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shin Lau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034610853","display_name":"Soo\u2010Hwang Teo","orcid":"https://orcid.org/0000-0002-0444-590X","observed_orcids":["https://orcid.org/0000-0002-0444-590X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo-Hwang Teo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013068093","display_name":"Sok Ching Cheong","orcid":"https://orcid.org/0000-0002-6765-9542","observed_orcids":["https://orcid.org/0000-0002-6765-9542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sok Cheong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0338,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.7611604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"4","first_page":"963","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8980000019073486},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mdm2-overexpression","display_name":"MDM2 overexpression","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776750431","wikidata":"https://www.wikidata.org/wiki/Q7117832","display_name":"p14arf","level":5,"score":0.8340539932250977},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.707306981086731},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7031877040863037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6974523663520813},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6717864274978638},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.656572699546814},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6252930760383606},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.5998871326446533},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4837510585784912},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.39136481285095215},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3877781927585602},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3743289113044739},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29375535249710083}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025803","descriptor_name":"Tumor Suppressor Protein p14ARF","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D031721","descriptor_name":"Piper betle","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.14.4.963","doi":"https://doi.org/10.3892/or.14.4.963","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.14.4.963","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:16142358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16142358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988722627","https://openalex.org/W2324774713","https://openalex.org/W1994094660","https://openalex.org/W1998430156","https://openalex.org/W1975890629","https://openalex.org/W4298007436","https://openalex.org/W2157287475","https://openalex.org/W636902396","https://openalex.org/W2067608470","https://openalex.org/W2081307685"],"abstract_inverted_index":{"The":[0],"majority":[1],"of":[2,5,14,34,38,58,121,158,178,181],"global":[3],"incidences":[4],"oral":[6,15,39,68,81,167],"cancer":[7,16,40,64,69],"occur":[8],"in":[9,19,24,42,49,52,62,66,88,99,105,141,146,166,176,183],"Asia,":[10],"and":[11,77,112,127,134],"the":[12,25,35,43,56,59,89,100,159,184],"aetiology":[13],"is":[17,23,30,46,162],"different":[18],"Asia":[20],"as":[21],"it":[22],"West.":[26],"However,":[27],"whereas":[28],"there":[29,45],"a":[31,118,163,179],"growing":[32],"understanding":[33,51],"molecular":[36],"mechanisms":[37],"progression":[41,65],"West,":[44],"little":[47],"progress":[48],"this":[50,73],"Asia.":[53],"In":[54,72],"particular,":[55],"role":[57],"p53":[60,90,101,128,160,185],"pathway":[61,161],"modulating":[63],"Asian":[67],"remains":[70],"unclear.":[71],"study,":[74],"we":[75],"micro-dissected":[76],"analysed":[78],"20":[79],"well-differentiated":[80],"squamous":[82,168],"cell":[83,169],"carcinoma":[84],"specimens":[85],"for":[86],"alterations":[87],"pathway.":[91,186],"We":[92],"found":[93],"that":[94,156],"6/20":[95,115],"samples":[96,116],"contained":[97],"mutations":[98],"gene":[102],"which":[103,171],"occurred":[104],"three":[106],"hotspots,":[107],"at":[108],"codon":[109],"203,":[110],"218":[111],"296.":[113],"Furthermore,":[114],"had":[117],"homozygous":[119],"deletion":[120,126],"p14ARF,":[122],"but":[123,144],"notably":[124],"p14ARF":[125],"mutation":[129],"events":[130],"were":[131],"often":[132],"independent":[133],"mutually":[135],"exclusive.":[136],"Strikingly,":[137],"MDM2":[138],"was":[139],"upregulated":[140],"20/20":[142],"samples,":[143],"not":[145],"3/3":[147],"normal":[148],"tissue":[149],"specimens.":[150],"Taken":[151],"together,":[152],"these":[153],"data":[154],"suggest":[155],"inactivation":[157],"frequent":[164],"event":[165],"carcinoma,":[170],"occurs":[172],"by":[173],"an":[174],"aberration":[175],"one":[177],"number":[180],"players":[182]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}