{"id":"https://openalex.org/W1971020007","doi":"https://doi.org/10.1016/j.bbrc.2006.07.014","title":"Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin","display_name":"Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin","publication_year":2006,"publication_date":"2006-07-25","ids":{"openalex":"https://openalex.org/W1971020007","doi":"https://doi.org/10.1016/j.bbrc.2006.07.014","mag":"1971020007","pmid":"https://pubmed.ncbi.nlm.nih.gov/16875675"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2006.07.014","doi":"https://doi.org/10.1016/j.bbrc.2006.07.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.07.014","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056476810","display_name":"Jan Paeshuyse","orcid":"https://orcid.org/0000-0003-2396-354X","observed_orcids":["https://orcid.org/0000-0003-2396-354X"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Paeshuyse","raw_affiliation_strings":["Rega Institute for Medical Research, Minderbroedersstraat 10, KU Leuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, KU Leuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008713330","display_name":"Lotte Coelmont","orcid":"https://orcid.org/0000-0002-7888-4534","observed_orcids":["https://orcid.org/0000-0002-7888-4534"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lotte Coelmont","raw_affiliation_strings":["Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052667034","display_name":"Inge Vliegen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Inge Vliegen","raw_affiliation_strings":["Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047901956","display_name":"Johan Van hemel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103443","display_name":"Kemin (Belgium)","ror":"https://ror.org/01jh73d13","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210103443"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Van hemel","raw_affiliation_strings":["Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium","institution_ids":["https://openalex.org/I4210103443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040962582","display_name":"Jan Vandenkerckhove","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103443","display_name":"Kemin (Belgium)","ror":"https://ror.org/01jh73d13","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210103443"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Vandenkerckhove","raw_affiliation_strings":["Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium","institution_ids":["https://openalex.org/I4210103443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022319088","display_name":"Eric Peys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103443","display_name":"Kemin (Belgium)","ror":"https://ror.org/01jh73d13","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210103443"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Peys","raw_affiliation_strings":["Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium","institution_ids":["https://openalex.org/I4210103443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021298063","display_name":"Benedikt Sas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103443","display_name":"Kemin (Belgium)","ror":"https://ror.org/01jh73d13","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210103443"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Benedikt Sas","raw_affiliation_strings":["Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kemin Pharma, Atealaan 4H, B-2200 Herentals, Belgium","institution_ids":["https://openalex.org/I4210103443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik De Clercq","raw_affiliation_strings":["Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Minderbroedersstraat 10, KULeuven, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089010495"],"corresponding_institution_ids":["https://openalex.org/I24156275"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.0694,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.85911907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"348","issue":"1","first_page":"139","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin","display_name":"artemisinin","score":0.890999972820282},{"id":"https://openalex.org/keywords/hemin","display_name":"hemin","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hcv-replicon","display_name":"HCV replicon","score":0.7789999842643738},{"id":"https://openalex.org/keywords/synergistic-antiviral-effect","display_name":"antiviral synergy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.5740000009536743},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7139999866485596},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.8086472749710083},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.7858865261077881},{"id":"https://openalex.org/C2777723881","wikidata":"https://www.wikidata.org/wiki/Q107315604","display_name":"Hemin","level":4,"score":0.7264181971549988},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6662478446960449},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.6346861720085144},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5223230719566345},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.49953269958496094},{"id":"https://openalex.org/C2781426373","wikidata":"https://www.wikidata.org/wiki/Q24766653","display_name":"NS5B","level":5,"score":0.4940336346626282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4870453178882599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4175716042518616},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39626026153564453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35450267791748047},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.2514202296733856},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.19432109594345093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14241555333137512},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13988664746284485},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.13919752836227417},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.13013818860054016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08256185054779053},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08001202344894409},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.05674329400062561},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006427","descriptor_name":"Hemin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012093","descriptor_name":"Replicon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbrc.2006.07.014","doi":"https://doi.org/10.1016/j.bbrc.2006.07.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.07.014","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:16875675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16875675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:426336","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1854/LU-426336","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0006-291X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W203587163","https://openalex.org/W1587419406","https://openalex.org/W1969451624","https://openalex.org/W1970605250","https://openalex.org/W1975077708","https://openalex.org/W1987306816","https://openalex.org/W2012698685","https://openalex.org/W2014895979","https://openalex.org/W2015823022","https://openalex.org/W2033721665","https://openalex.org/W2035784901","https://openalex.org/W2054174404","https://openalex.org/W2061941938","https://openalex.org/W2069531923","https://openalex.org/W2073385105","https://openalex.org/W2075095707","https://openalex.org/W2080543752","https://openalex.org/W2082933842","https://openalex.org/W2083634651","https://openalex.org/W2086891449","https://openalex.org/W2095199759","https://openalex.org/W2097913517","https://openalex.org/W2098184601","https://openalex.org/W2102383058","https://openalex.org/W2106239124","https://openalex.org/W2108523194","https://openalex.org/W2111736586","https://openalex.org/W2136523601","https://openalex.org/W2139878820","https://openalex.org/W2142777712","https://openalex.org/W2148976224","https://openalex.org/W2150368001","https://openalex.org/W2151898297","https://openalex.org/W2156153913","https://openalex.org/W2165260654","https://openalex.org/W2168586962","https://openalex.org/W2401951340","https://openalex.org/W2461658383","https://openalex.org/W2792087431","https://openalex.org/W6718935404"],"related_works":["https://openalex.org/W1972925685","https://openalex.org/W2226786474","https://openalex.org/W2028913205","https://openalex.org/W2027240524","https://openalex.org/W2111597501","https://openalex.org/W4214925379","https://openalex.org/W2801562415","https://openalex.org/W2064103631","https://openalex.org/W2981495397","https://openalex.org/W2782110488"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
