{"id":"https://openalex.org/W1971017462","doi":"https://doi.org/10.3109/10837450.2013.871033","title":"Preparation and characterization of polymorphs of the glucocorticoid deflazacort","display_name":"Preparation and characterization of polymorphs of the glucocorticoid deflazacort","publication_year":2014,"publication_date":"2014-01-13","ids":{"openalex":"https://openalex.org/W1971017462","doi":"https://doi.org/10.3109/10837450.2013.871033","mag":"1971017462","pmid":"https://pubmed.ncbi.nlm.nih.gov/24417709"},"language":"en","primary_location":{"id":"doi:10.3109/10837450.2013.871033","doi":"https://doi.org/10.3109/10837450.2013.871033","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10837450.2013.871033","pdf_url":null,"source":{"id":"https://openalex.org/S80622011","display_name":"Pharmaceutical Development and Technology","issn_l":"1083-7450","issn":["1083-7450","1097-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Development and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11336/25277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035604119","display_name":"Diego Kassuha","orcid":"https://orcid.org/0000-0002-6624-1523","observed_orcids":["https://orcid.org/0000-0002-6624-1523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diego E. Kassuha","raw_affiliation_strings":["Departamento de Farmacia and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040131672","display_name":"Virginia Aiassa","orcid":"https://orcid.org/0000-0002-4616-7434","observed_orcids":["https://orcid.org/0000-0002-4616-7434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virginia Aiassa","raw_affiliation_strings":["Departamento de Farmacia and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003519537","display_name":"Flavia P. Bruno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flavia P. Bruno","raw_affiliation_strings":["Departamento de Farmacia and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041000120","display_name":"Gabriel Ricardo Cuadra","orcid":"https://orcid.org/0000-0001-5007-521X","observed_orcids":["https://orcid.org/0000-0001-5007-521X"]},"institutions":[{"id":"https://openalex.org/I166401450","display_name":"Universidad Nacional de C\u00f3rdoba","ror":"https://ror.org/056tb7j80","country_code":"AR","type":"education","lineage":["https://openalex.org/I166401450"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Gabriel Cuadra","raw_affiliation_strings":["Departamento de Farmacolog\u00eda, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, C\u00f3rdoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, C\u00f3rdoba, Argentina","institution_ids":["https://openalex.org/I166401450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082527270","display_name":"Norma R. Sperandeo","orcid":"https://orcid.org/0000-0002-2380-6328","observed_orcids":["https://orcid.org/0000-0002-2380-6328"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Norma R. Sperandeo","raw_affiliation_strings":["Departamento de Farmacia and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082527270"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4041,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55273359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"4","first_page":"401","last_page":"409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.08569999784231186,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10389","display_name":"Polymer crystallization and properties","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deflazacort","display_name":"deflazacort","score":1.0},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.8640000224113464},{"id":"https://openalex.org/keywords/amorphous-drug","display_name":"amorphous drug","score":0.6700000166893005},{"id":"https://openalex.org/keywords/crystal-forms","display_name":"crystal forms","score":0.5849999785423279},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.6959999799728394},{"id":"https://openalex.org/keywords/glass-crystallization","display_name":"devitrification","score":0.7760000228881836},{"id":"https://openalex.org/keywords/solid-state-stability","display_name":"solid-state stability","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8330000042915344},{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.5860000252723694},{"id":"https://openalex.org/keywords/pressure-induced-amorphization","display_name":"pressure-induced amorphization","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2776376305","wikidata":"https://www.wikidata.org/wiki/Q779118","display_name":"Deflazacort","level":3,"score":0.7601989507675171},{"id":"https://openalex.org/C56052488","wikidata":"https://www.wikidata.org/wiki/Q103382","display_name":"Amorphous solid","level":2,"score":0.707971453666687},{"id":"https://openalex.org/C187714232","wikidata":"https://www.wikidata.org/wiki/Q2745207","display_name":"Anhydrous","level":2,"score":0.7012501358985901},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.6141849756240845},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.603971540927887},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5675513744354248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5366674661636353},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.46252259612083435},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40716397762298584},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3552406430244446},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.353801429271698},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35046589374542236},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.34792304039001465},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2513001561164856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13604426383972168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08422666788101196},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/10837450.2013.871033","doi":"https://doi.org/10.3109/10837450.2013.871033","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10837450.2013.871033","pdf_url":null,"source":{"id":"https://openalex.org/S80622011","display_name":"Pharmaceutical Development and Technology","issn_l":"1083-7450","issn":["1083-7450","1097-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Development and Technology","raw_type":"journal-article"},{"id":"pmid:24417709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24417709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical development and technology","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/25277","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/25277","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ri.conicet.gov.ar:11336/25277","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/25277","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W651534235","https://openalex.org/W1544389379","https://openalex.org/W1576092319","https://openalex.org/W1581483950","https://openalex.org/W1590254871","https://openalex.org/W1969128347","https://openalex.org/W1971775753","https://openalex.org/W1974891606","https://openalex.org/W1976058073","https://openalex.org/W1976153742","https://openalex.org/W1978169969","https://openalex.org/W1981588418","https://openalex.org/W1996789724","https://openalex.org/W2008576347","https://openalex.org/W2014258734","https://openalex.org/W2015224925","https://openalex.org/W2016591251","https://openalex.org/W2019544450","https://openalex.org/W2020544444","https://openalex.org/W2022931452","https://openalex.org/W2031934036","https://openalex.org/W2037821082","https://openalex.org/W2064468313","https://openalex.org/W2065890476","https://openalex.org/W2067507455","https://openalex.org/W2067957528","https://openalex.org/W2083940938","https://openalex.org/W2086603786","https://openalex.org/W2086736722","https://openalex.org/W2087713059","https://openalex.org/W2102136926","https://openalex.org/W2128034654","https://openalex.org/W2506880365","https://openalex.org/W4237807571","https://openalex.org/W4243402676","https://openalex.org/W4285674535"],"related_works":["https://openalex.org/W1964824806","https://openalex.org/W2031934036","https://openalex.org/W1489898156","https://openalex.org/W2020544444","https://openalex.org/W4391249080","https://openalex.org/W2996235969","https://openalex.org/W2057956735","https://openalex.org/W1992216518","https://openalex.org/W3203023486","https://openalex.org/W1981891396"],"abstract_inverted_index":{"The":[0,21,93],"polymorphism":[1,30],"of":[2,11,23,31,102,141,165,195],"new":[3],"and":[4,18,82,96,104,119,135,168,185,198],"old":[5],"active":[6],"pharmaceutical":[7],"ingredients":[8],"(APIs)":[9],"is":[10,67,175],"great":[12],"importance":[13],"due":[14],"to":[15,27,69,160,180],"performance,":[16],"stability":[17],"processability":[19],"aspects.":[20],"objective":[22],"this":[24,41,49],"study":[25],"was":[26,59,155,171],"investigate":[28],"the":[29,62,110,120,142,146,163],"deflazacort":[32],"(DEF),":[33],"a":[34,74,77],"glucocorticoid":[35],"discovered":[36],">40":[37],"years":[38],"ago,":[39],"since":[40],"phenomenon":[42],"has":[43,188],"not":[44,149],"been":[45],"previously":[46],"investigated":[47],"for":[48,54,61],"API.":[50],"Using":[51],"different":[52,182],"methods":[53],"solid":[55],"form":[56],"screening,":[57],"it":[58,154],"determined":[60,156],"first":[63],"time":[64],"that":[65,128,157,173,186],"DEF":[66,174],"able":[68],"exist":[70],"as":[71],"three":[72],"forms:":[73],"crystalline":[75,143,183],"(DEF-1);":[76],"hydrated":[78],"X-ray":[79],"amorphous":[80,85],"(DEF-t-bw)":[81],"an":[83],"anhydrous":[84],"phase":[86],"(DEF-g)":[87],"obtained":[88],"from":[89],"manually":[90],"grinding":[91],"DEF-1.":[92],"in":[94,97,114,124,133,136,193],"vitro":[95,134],"vivo":[98,137],"dissolution":[99],"rates":[100],"(DRs)":[101],"DEF-1":[103,161,192],"DEF-t-bw,":[105],"which":[106],"were":[107,148],"measured":[108],"using":[109],"rotating":[111],"disk":[112],"method":[113],"water":[115],"at":[116],"37":[117],"\u00b0C":[118],"pellet":[121],"implantation":[122],"technique":[123],"rats,":[125],"respectively,":[126],"indicated":[127],"DEF-t-bw":[129,158,187],"exhibited":[130],"slightly":[131],"faster":[132],"DRs":[138,197],"than":[139],"those":[140],"form,":[144],"but":[145],"values":[147],"significantly":[150],"different.":[151],"In":[152],"addition,":[153],"devitrifies":[159],"by":[162],"effect":[164],"pressure,":[166],"humidity":[167],"heat.":[169],"It":[170],"concluded":[172],"glucorticoid":[176],"with":[177],"low":[178],"tendency":[179],"exhibit":[181],"forms":[184],"no":[189],"advantages":[190],"over":[191],"terms":[194],"solubility,":[196],"solid-state":[199],"stability.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}