{"id":"https://openalex.org/W1970979744","doi":"https://doi.org/10.1016/j.semradonc.2006.11.009","title":"Normal Tissue Tolerance Dose Metrics for Radiation Therapy of Major Organs","display_name":"Normal Tissue Tolerance Dose Metrics for Radiation Therapy of Major Organs","publication_year":2007,"publication_date":"2007-03-28","ids":{"openalex":"https://openalex.org/W1970979744","doi":"https://doi.org/10.1016/j.semradonc.2006.11.009","mag":"1970979744","pmid":"https://pubmed.ncbi.nlm.nih.gov/17395043"},"language":"en","primary_location":{"id":"doi:10.1016/j.semradonc.2006.11.009","doi":"https://doi.org/10.1016/j.semradonc.2006.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semradonc.2006.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S104833954","display_name":"Seminars in Radiation Oncology","issn_l":"1053-4296","issn":["1053-4296","1532-9461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081365127","display_name":"Michael T. Milano","orcid":"https://orcid.org/0000-0001-8676-2855","observed_orcids":["https://orcid.org/0000-0001-8676-2855"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael T. Milano","raw_affiliation_strings":["Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Michael_milano@urmc.rochester.edu","Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Michael_milano@urmc.rochester.edu","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002120651","display_name":"Louis S. Constine","orcid":"https://orcid.org/0000-0003-0742-1740","observed_orcids":["https://orcid.org/0000-0003-0742-1740"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis S. Constine","raw_affiliation_strings":["Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044584621","display_name":"Paul G Okunieff","orcid":"https://orcid.org/0000-0003-1937-9316","observed_orcids":["https://orcid.org/0000-0003-1937-9316"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Okunieff","raw_affiliation_strings":["Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081365127"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":3330,"currency":"USD","value_usd":3330},"apc_paid":null,"fwci":1.5275,"has_fulltext":false,"cited_by_count":171,"citation_normalized_percentile":{"value":0.76785714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"17","issue":"2","first_page":"131","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-tissue-tolerance","display_name":"normal tissue tolerance","score":0.9639999866485596},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.800000011920929},{"id":"https://openalex.org/keywords/dose-volume-histograms","display_name":"dose-volume histograms","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dose-metrics","display_name":"dose metrics","score":0.7990000247955322},{"id":"https://openalex.org/keywords/radiation-dose-constraints","display_name":"radiation dose constraints","score":0.7429999709129333},{"id":"https://openalex.org/keywords/organs-at-risk","display_name":"organs at risk","score":0.6439999938011169},{"id":"https://openalex.org/keywords/toxicity-risk-prediction","display_name":"toxicity risk prediction","score":0.5370000004768372},{"id":"https://openalex.org/keywords/organ-at-risk-dose","display_name":"organ at risk dose","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8393501043319702},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6567066311836243},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5773829817771912},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5703831911087036},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.5217562317848206},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.4974081814289093},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4567303955554962},{"id":"https://openalex.org/C2987700449","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Radiation dose","level":2,"score":0.41845205426216125},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.41736727952957153},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3631312847137451},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22963780164718628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18528911471366882},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17276090383529663},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.08153823018074036},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semradonc.2006.11.009","doi":"https://doi.org/10.1016/j.semradonc.2006.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semradonc.2006.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S104833954","display_name":"Seminars in Radiation Oncology","issn_l":"1053-4296","issn":["1053-4296","1532-9461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Radiation Oncology","raw_type":"journal-article"},{"id":"pmid:17395043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17395043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in radiation oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W594237824","https://openalex.org/W1545816967","https://openalex.org/W1781834802","https://openalex.org/W1907802084","https://openalex.org/W1964052391","https://openalex.org/W1964759286","https://openalex.org/W1965376903","https://openalex.org/W1968626722","https://openalex.org/W1973277978","https://openalex.org/W1980829076","https://openalex.org/W1981346821","https://openalex.org/W1986347930","https://openalex.org/W1988027495","https://openalex.org/W1994439728","https://openalex.org/W1995944130","https://openalex.org/W1995980762","https://openalex.org/W2001725855","https://openalex.org/W2004575539","https://openalex.org/W2005839262","https://openalex.org/W2008082672","https://openalex.org/W2010047598","https://openalex.org/W2010204246","https://openalex.org/W2011242979","https://openalex.org/W2015911650","https://openalex.org/W2016557692","https://openalex.org/W2016982738","https://openalex.org/W2017298571","https://openalex.org/W2019774627","https://openalex.org/W2020155753","https://openalex.org/W2028933139","https://openalex.org/W2030023766","https://openalex.org/W2033366141","https://openalex.org/W2033806488","https://openalex.org/W2036018628","https://openalex.org/W2036167723","https://openalex.org/W2037435427","https://openalex.org/W2039945983","https://openalex.org/W2040296209","https://openalex.org/W2042545532","https://openalex.org/W2043945205","https://openalex.org/W2044383209","https://openalex.org/W2044480165","https://openalex.org/W2044777038","https://openalex.org/W2045061643","https://openalex.org/W2045724824","https://openalex.org/W2047122497","https://openalex.org/W2047919463","https://openalex.org/W2053794285","https://openalex.org/W2056643793","https://openalex.org/W2059531660","https://openalex.org/W2059702431","https://openalex.org/W2059987247","https://openalex.org/W2061444197","https://openalex.org/W2061581927","https://openalex.org/W2063960686","https://openalex.org/W2067047106","https://openalex.org/W2069506836","https://openalex.org/W2070961524","https://openalex.org/W2071032101","https://openalex.org/W2071418795","https://openalex.org/W2080573864","https://openalex.org/W2091013692","https://openalex.org/W2092435844","https://openalex.org/W2094011295","https://openalex.org/W2096455354","https://openalex.org/W2097512974","https://openalex.org/W2100355025","https://openalex.org/W2100792870","https://openalex.org/W2106257072","https://openalex.org/W2109439161","https://openalex.org/W2111273332","https://openalex.org/W2113092282","https://openalex.org/W2116307402","https://openalex.org/W2119298887","https://openalex.org/W2122114750","https://openalex.org/W2127357697","https://openalex.org/W2129584252","https://openalex.org/W2138538184","https://openalex.org/W2139807361","https://openalex.org/W2141650710","https://openalex.org/W2145272969","https://openalex.org/W2146421906","https://openalex.org/W2147365619","https://openalex.org/W2148845568","https://openalex.org/W2151238165","https://openalex.org/W2152722415","https://openalex.org/W2155422011","https://openalex.org/W2159751006","https://openalex.org/W2165340497","https://openalex.org/W2169874604","https://openalex.org/W2170253607","https://openalex.org/W2170812597","https://openalex.org/W2171180669","https://openalex.org/W2410982159","https://openalex.org/W4250884848","https://openalex.org/W4252516825"],"related_works":["https://openalex.org/W2040181951","https://openalex.org/W1986116955","https://openalex.org/W2062950404","https://openalex.org/W2337023045","https://openalex.org/W1968896057","https://openalex.org/W1977952829","https://openalex.org/W4405321133","https://openalex.org/W2513749408","https://openalex.org/W4385382699","https://openalex.org/W2044729405"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}