{"id":"https://openalex.org/W1970806325","doi":"https://doi.org/10.1210/jcem-47-3-633","title":"Calcium and Salmon Calcitonin in Treatment of Osteoporosis*","display_name":"Calcium and Salmon Calcitonin in Treatment of Osteoporosis*","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W1970806325","doi":"https://doi.org/10.1210/jcem-47-3-633","mag":"1970806325","pmid":"https://pubmed.ncbi.nlm.nih.gov/263316"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-47-3-633","doi":"https://doi.org/10.1210/jcem-47-3-633","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-47-3-633","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110396870","display_name":"Jenifer Jowsey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JENIFER JOWSEY","raw_affiliation_strings":["Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108401950","display_name":"B. Lawrence Riggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. LAWRENCE RIGGS","raw_affiliation_strings":["Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100708858","display_name":"Patrick John Kelly","orcid":"https://orcid.org/0000-0002-5015-0977","observed_orcids":["https://orcid.org/0000-0002-5015-0977"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PATRICK J. KELLY","raw_affiliation_strings":["Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013318978","display_name":"David L. Hoffman","orcid":"https://orcid.org/0000-0002-8661-3291","observed_orcids":["https://orcid.org/0000-0002-8661-3291"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID L. HOFFMAN","raw_affiliation_strings":["Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Orthopedic Research and the Division of Endocrinology/Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":11.8635,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.98513986,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"47","issue":"3","first_page":"633","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9520000219345093},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bone-mass","display_name":"bone mass","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/osteoporosis-prevention","display_name":"osteoporosis prevention","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.8985145092010498},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.8346149921417236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7813903093338013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7552863955497742},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.7173037528991699},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.689636766910553},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6895284056663513},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.6055780649185181},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.584831178188324},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.5082249641418457},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.43943560123443604},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43045246601104736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33899587392807007}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-47-3-633","doi":"https://doi.org/10.1210/jcem-47-3-633","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-47-3-633","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:263316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/263316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W271699332","https://openalex.org/W1830558357","https://openalex.org/W1964392152","https://openalex.org/W1971124839","https://openalex.org/W1996555371","https://openalex.org/W1996776040","https://openalex.org/W2014216243","https://openalex.org/W2017421228","https://openalex.org/W2023799271","https://openalex.org/W2036060203","https://openalex.org/W2087707463","https://openalex.org/W2092590631","https://openalex.org/W2096389562","https://openalex.org/W2098027158","https://openalex.org/W2099604753","https://openalex.org/W2144347948","https://openalex.org/W2156906724","https://openalex.org/W2162627700","https://openalex.org/W2278715401","https://openalex.org/W2280851346","https://openalex.org/W2340837163","https://openalex.org/W2921559526"],"related_works":["https://openalex.org/W315616074","https://openalex.org/W76779435","https://openalex.org/W2018830831","https://openalex.org/W2053476416","https://openalex.org/W2386701905","https://openalex.org/W2503306651","https://openalex.org/W1614040894","https://openalex.org/W2087707463","https://openalex.org/W202060626","https://openalex.org/W2339379837"],"abstract_inverted_index":{"Calcitonin":[0],"has":[1,181],"been":[2],"considered":[3,75],"of":[4,10,37,45,53,69,98,137,154,159,173],"therapeutic":[5,79],"value":[6],"in":[7,13,48,58,157,186],"osteoporosis":[8],"because":[9],"its":[11],"effects":[12,103],"tissue":[14],"culture.":[15],"In":[16],"the":[17,21,34,102,140,171,187],"whole":[18],"animal,":[19],"however,":[20],"predominant":[22],"result":[23],"seems":[24,177],"to":[25,32,64,87,139,148],"be":[26,30,65],"hypocalcemia,":[27],"which":[28],"might":[29],"expected":[31],"have":[33],"opposite":[35],"effect":[36,185],"stimulating":[38],"parathyroid":[39,125],"hormone":[40,126],"secretion":[41],"and":[42,55,71,101,106,109,111,115,120,131,142],"therefore":[43,74],"resorption":[44,114],"bone.":[46],"Indeed,":[47],"a":[49,76,96],"short":[50],"term":[51],"study":[52],"3-":[54],"4-month":[56],"duration":[57],"osteoporotic":[59],"women,":[60],"this":[61,82],"was":[62,73,85],"found":[63],"so.":[66],"A":[67],"combination":[68],"calcium":[70,108,141],"calcitonin":[72,138,180],"more":[77],"promising":[78],"alternative":[80],"for":[81,95],"disease.":[83,188],"Calcium":[84,119],"given":[86],"26":[88],"patients,":[89],"alone":[90],"or":[91,164],"with":[92,163],"vitamin":[93,121,143,166],"D,":[94],"period":[97],"15":[99],"months,":[100],"on":[104,112],"serum":[105,124],"urine":[107],"phosphorus":[110],"bone":[113,129,160],"formation":[116],"were":[117],"evaluated.":[118],"D":[122,144,167],"decreased":[123],"levels,":[127],"reduced":[128],"resorption,":[130],"increased":[132],"urinary":[133],"calcium.":[134],"The":[135],"addition":[136],"did":[145],"not":[146],"seem":[147],"change":[149,158],"these":[150],"effects.":[151],"Neither":[152],"form":[153],"treatment":[155],"resulted":[156],"mass.":[161],"Calcium,":[162],"without":[165],"supplements,":[168],"may":[169],"prevent":[170],"development":[172],"osteoporosis,":[174],"but":[175],"it":[176],"unlikely":[178],"that":[179],"any":[182],"additional":[183],"desirable":[184]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}