{"id":"https://openalex.org/W1970751992","doi":"https://doi.org/10.1002/adma.200304621","title":"Cell\u2010Responsive Synthetic Hydrogels","display_name":"Cell\u2010Responsive Synthetic Hydrogels","publication_year":2003,"publication_date":"2003-06-02","ids":{"openalex":"https://openalex.org/W1970751992","doi":"https://doi.org/10.1002/adma.200304621","mag":"1970751992"},"language":"en","primary_location":{"id":"doi:10.1002/adma.200304621","doi":"https://doi.org/10.1002/adma.200304621","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adma.200304621","pdf_url":null,"source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/124859","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004455575","display_name":"Matthias P. L\u00fctolf","orcid":"https://orcid.org/0000-0002-5898-305X","observed_orcids":["https://orcid.org/0000-0002-5898-305X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210090941","display_name":"Institute for Biomedical Engineering","ror":"https://ror.org/00baskk38","country_code":"CH","type":"facility","lineage":["https://openalex.org/I202697423","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M.P. Lutolf","raw_affiliation_strings":["Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036715847","display_name":"George P. Raeber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210090941","display_name":"Institute for Biomedical Engineering","ror":"https://ror.org/00baskk38","country_code":"CH","type":"facility","lineage":["https://openalex.org/I202697423","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G.P. Raeber","raw_affiliation_strings":["Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112035675","display_name":"Andreas Hugo Zisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210090941","display_name":"Institute for Biomedical Engineering","ror":"https://ror.org/00baskk38","country_code":"CH","type":"facility","lineage":["https://openalex.org/I202697423","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A.H. Zisch","raw_affiliation_strings":["Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075693768","display_name":"Nicola Tirelli","orcid":"https://orcid.org/0000-0002-4879-3949","observed_orcids":["https://orcid.org/0000-0002-4879-3949"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210090941","display_name":"Institute for Biomedical Engineering","ror":"https://ror.org/00baskk38","country_code":"CH","type":"facility","lineage":["https://openalex.org/I202697423","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"N. Tirelli","raw_affiliation_strings":["Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich (ETHZ) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031517705","display_name":"Jeffrey A. Hubbell","orcid":"https://orcid.org/0000-0003-0276-5456","observed_orcids":["https://orcid.org/0000-0003-0276-5456"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J.A. Hubbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031517705"],"corresponding_institution_ids":[],"apc_list":{"value":6070,"currency":"USD","value_usd":6070},"apc_paid":null,"fwci":9.0158,"has_fulltext":false,"cited_by_count":526,"citation_normalized_percentile":{"value":0.99042588,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"15","issue":"11","first_page":"888","last_page":"892"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-hydrogels","display_name":"synthetic hydrogels","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cell-adhesion-peptides","display_name":"cell adhesion peptides","score":0.8450000286102295},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.7950000166893005},{"id":"https://openalex.org/keywords/michael-addition","display_name":"Michael addition","score":0.7369999885559082},{"id":"https://openalex.org/keywords/3d-cell-migration","display_name":"3D cell migration","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cell-surface-protease","display_name":"cell surface protease","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.7840030193328857},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.7335771322250366},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.7156691551208496},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7022860646247864},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6769509315490723},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6403013467788696},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5944855213165283},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5498214364051819},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5464703440666199},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.45701295137405396},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.437442809343338},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3899938464164734},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3308175802230835},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.2872491776943207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21142920851707458},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1565803587436676},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14632627367973328},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10249340534210205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0897308886051178},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0550805926322937},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/adma.200304621","doi":"https://doi.org/10.1002/adma.200304621","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adma.200304621","pdf_url":null,"source":{"id":"https://openalex.org/S99352657","display_name":"Advanced Materials","issn_l":"0935-9648","issn":["0935-9648","1521-4095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Materials","raw_type":"journal-article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/b1925310-eb93-4504-a666-c60f0d71fdca","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/b1925310-eb93-4504-a666-c60f0d71fdca","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lutolf, M P, Raeber, G P, Zisch, A H, Tirelli, N & Hubbell, J A 2003, 'Cell-responsive synthetic hydrogels', Advanced Materials, vol. 15, no. 11, pp. 888-892. https://doi.org/10.1002/adma.200304621","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:124859","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/124859","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:124859","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/124859","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:124859","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/124859","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1515338173","https://openalex.org/W1555210583","https://openalex.org/W1926301789","https://openalex.org/W1963689285","https://openalex.org/W1967265143","https://openalex.org/W1973089587","https://openalex.org/W1974260210","https://openalex.org/W1976831807","https://openalex.org/W1996703250","https://openalex.org/W2013205720","https://openalex.org/W2031525159","https://openalex.org/W2041558541","https://openalex.org/W2049701513","https://openalex.org/W2051086698","https://openalex.org/W2057586855","https://openalex.org/W2062694132","https://openalex.org/W2063831691","https://openalex.org/W2067345253","https://openalex.org/W2067928133","https://openalex.org/W2072797273","https://openalex.org/W2076255801","https://openalex.org/W2078386086","https://openalex.org/W2081789842","https://openalex.org/W2083922905","https://openalex.org/W2086610977","https://openalex.org/W2087208805","https://openalex.org/W2091100304","https://openalex.org/W2100501295","https://openalex.org/W2128049766","https://openalex.org/W2137134545","https://openalex.org/W2317012207","https://openalex.org/W2482531400","https://openalex.org/W4237331911","https://openalex.org/W4388324919"],"related_works":["https://openalex.org/W6940206126","https://openalex.org/W2161549139","https://openalex.org/W1562490776","https://openalex.org/W2918014271","https://openalex.org/W3157598929","https://openalex.org/W2101209763","https://openalex.org/W2340863008","https://openalex.org/W383538129","https://openalex.org/W1998289682","https://openalex.org/W2418246280"],"abstract_inverted_index":{"Synthetic":[0],"biomaterial":[1],"matrices":[2],"have":[3],"been":[4],"formed":[5],"in":[6,36],"the":[7],"presence":[8],"of":[9],"cells":[10,42],"by":[11],"a":[12,17,22,28],"Michael\u2010type":[13],"addition":[14],"reaction":[15],"between":[16],"difunctional":[18],"protease":[19],"substrate":[20],"peptide,":[21,26],"monofunctional":[23],"cell":[24,48],"adhesion":[25],"and":[27],"tetrafunctional":[29],"poly(ethylene":[30],"glycol).":[31],"These":[32],"materials":[33],"locally":[34],"degrade":[35],"response":[37],"to":[38,43],"cell\u2010surface":[39],"proteases,":[40],"allowing":[41],"create":[44],"paths":[45],"for":[46],"3D":[47],"migration":[49],"(see":[50],"Figure).":[51]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":54},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":37}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
